Ionis Pharmaceuticals Inc. (IONS)
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Ionis Pharmaceuticals Inc. (IONS) reported revenue of $268 million for Q2 FY2026, the quarter ended 30 June 2026, down 40.7% on the same quarter a year earlier. Net income was -$115 million, and diluted earnings per share $-0.69. The figures are the company's own, from the 10-Q it filed with the SEC on 29 July 2026.
Revenue$268 milliondown 40.7%
Net income-$115 million
Diluted EPS$-0.69
QuarterQ2 FY2026ended 30 June 2026
Ionis Pharmaceuticals (IONS) in brief
Ionis Pharmaceuticals (IONS) reported revenue of $944 million for fiscal 2025, the year ended 31 December 2025, up 33.8% on the year before.
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Net loss was $381 million and the diluted loss per share $2.38. Revenue was $705 million in fiscal 2024, $788 million in fiscal 2023, $587 million in fiscal 2022 and $810 million in fiscal 2021. Net income in the same years was a loss of $454 million, a loss of $366 million, a loss of $270 million and a loss of $29 million. Over the twelve months to 30 June 2026, Ionis Pharmaceuticals reported revenue of $874 million and net loss of $565 million. Revenue grew 5.3% a year, compounded, over the five years to fiscal 2025. Ionis Pharmaceuticals had 166 million shares outstanding at the latest filed count. At 30 June 2026 it carried $1.3 billion of debt and $350 million of cash. At the close of 27 October 2026 the market cap of Ionis Pharmaceuticals was $7.3 billion.Ratios
From the filings
ROE-128.5%
ROCE-33.7%
Operating margin-68.0%
Net margin-64.7%
FCF margin-64.2%
Interest cover-31.58
Debt to equity3.01
Cash conversionn/a
Share count, last 12 months4.0%
Sales CAGR, 3 years17.1%
Profit CAGR, 3 yearsn/a
EPS, TTM-$3.46
At the close of 27 October 2026
Price$43.95
Market cap$7.3 billion
Stock P/En/a
Price to book16.56
EV / EBITDAn/a
Dividend yieldn/a
Market cap / sales8.33
52-week high$86.50
52-week low$42.36
Price, 1 year-39.8%
Price CAGR, 3 years-0.1%
Price CAGR, 5 years7.1%
Worked from the filed figures; hover a name for the formula.
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The priced ones use the latest price, the last regular-hours trade on IEX. Debt to equity here stands on the borrowing lines of Ionis Pharmaceuticals Inc.'s balance sheet, added together, finance leases inside them only where the company puts them there; operating leases are a separate line. Nothing here is a valuation or a view.IONSgreeksoup.ai
Daily prices to 27 October 2026, adjusted for splits; from 28 September 2026 each day's price is the last regular-hours trade on IEX.
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Data provided for free by IEX. By accessing or using IEX Historical Data, you agree to the IEX Historical Data Terms of Use. Day by day for the last three years; before that one point a week, carrying the week's last close and its average daily volume, so a volume bar means the same thing across the whole series; the bars sit under the price on their own scale, on the right. The moving averages need consecutive days and are drawn from the daily part. P/E is the close over the trailing four quarters' EPS as filed at each filing date, on the current share count; the dashed line is the median over the range shown. Sales and margin are quarterly revenue and the operating margin from the tables above. EV/EBITDA, price to book and market cap to sales use the latest filed balance sheet and share count at each date. Before the quarters on file begin, P/E, price to book and market cap to sales stand on each annual report from the day it was filed. Drawn in your browser; the range and overlay you pick are remembered here only.The public record on IONS
| Dividends | no dividend in its filings for fiscal 2008 onward |
| Filings | 30 in twelve months: 22 current reports (8-K), about 14 regulation FD disclosure; 13 other events; 5 results of operations; 2 officer or director change; 2 material agreement |
| Planned insider sales | 62 Form 144 notices in twelve months, $147.6 million; latest 16 October 2026 |
| Options tape | put/call 0.44 by open interest at the 27 October 2026 close; the straddle prices a 11.3% move to 20 November 2026 |
| 13F holders | 516 funds reported a position for the quarter to 30 June 2026; largest FMR LLC |
| Insider trading | 124 sales and 2 purchases on Form 4 in twelve months |
| Congress | 0 House trades disclosed in six months |
| Short interest | 20.7 million shares short, 7.65 days to cover at 15 October 2026 |
| Documents | the 10-K, the 10-Qs, the proxy and 5 earnings press releases, each linked |
Quarterly results, the last 20 quarters
| Q3 FY2021 | Q4 FY2021 | Q1 FY2022 | Q2 FY2022 | Q3 FY2022 | Q4 FY2022 | Q1 FY2023 | Q2 FY2023 | Q3 FY2023 | Q4 FY2023 | Q1 FY2024 | Q2 FY2024 | Q3 FY2024 | Q4 FY2024 | Q1 FY2025 | Q2 FY2025 | Q3 FY2025 | Q4 FY2025 | Q1 FY2026 | Q2 FY2026 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | 133 | 440 | 142 | 134 | 160 | 152 | 131 | 188 | 144 | 325 | 119 | 225 | 134 | 227 | 132 | 452 | 157 | 203 | 246 | 268 |
| Cost of revenue | 3.1 | 2.2 | 4.2 | 4.7 | 1.5 | 3.7 | 1.3 | 2.5 | 2.2 | 3.1 | 2.2 | 4.2 | 1.1 | 3.8 | 1.5 | 4.2 | 2.3 | 8.0 | 3.0 | 2.7 |
| Gross profit | 130 | 438 | 138 | 129 | 158 | 148 | 129 | 186 | 142 | 321 | 117 | 221 | 133 | 223 | 130 | 448 | 154 | 195 | 243 | 265 |
| Gross margin | 98% | 99% | 97% | 96% | 99% | 98% | 99% | 99% | 98% | 99% | 98% | 98% | 99% | 98% | 99% | 99% | 99% | 96% | 99% | 99% |
| SG&A | 31.1 | 37.6 | 34.1 | 33.8 | 34.4 | 48.0 | 45.5 | 46.1 | 70.0 | 71.0 | 52.6 | 65.1 | 61.6 | 88.1 | 76.2 | 90.6 | 96.8 | 130 | 150 | 150 |
| Operating income | -85.8 | 221 | -57.5 | -85.5 | -59.2 | -208 | -114 | -90.2 | -143 | -6.1 | -150 | -66.1 | -149 | -111 | -147 | 140 | -160 | -214 | -117 | -102 |
| Operating margin | -65% | 50% | -41% | -64% | -37% | -137% | -87% | -48% | -99% | -2% | -125% | -29% | -111% | -49% | -112% | 31% | -102% | -105% | -48% | -38% |
| Interest expense | 2.3 | 2.2 | 2.1 | 2.1 | 2.1 | 1.7 | 1.6 | 2.3 | 4.2 | 4.6 | 4.2 | 4.5 | 4.2 | 4.2 | 4.1 | 4.1 | 4.2 | 4.8 | 5.2 | 4.6 |
| Pre-tax income | -83.8 | 225 | -64.1 | -103 | -46.7 | -44.3 | -113 | -77.4 | -141 | -2.8 | -143 | -66.2 | -144 | -107 | -147 | 124 | -128 | -228 | -92.3 | -113 |
| Tax rate | n/a | 0% | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | -0% | n/a | n/a | n/a | n/a |
| Net income | -82.5 | 225 | -65.2 | -105 | -47.0 | -52.4 | -124 | -85.3 | -147 | -9.3 | -143 | -66.3 | -140 | -104 | -147 | 124 | -129 | -229 | -92.5 | -115 |
| Net margin | -62% | 51% | -46% | -79% | -29% | -35% | -95% | -45% | -102% | -3% | -120% | -29% | -105% | -46% | -112% | 27% | -82% | -113% | -38% | -43% |
| Diluted EPS | -$0.58 | $1.41 | -$0.46 | -$0.74 | -$0.33 | -$0.37 | -$0.87 | -$0.60 | -$1.03 | -$0.06 | -$0.98 | -$0.45 | -$0.95 | -$0.66 | -$0.93 | $0.70 | -$0.80 | -$1.41 | -$0.56 | -$0.69 |
| Operating cash flow | -55.6 | 204 | -31.6 | -18.1 | -24.4 | -200 | -134 | -97.4 | -109 | 32.9 | -150 | -120 | -115 | -116 | -151 | 151 | -131 | -138 | -793 | 566 |
| Capital expenditure | 3.3 | 2.5 | 2.7 | 3.3 | 5.5 | 4.1 | 10.5 | 12.0 | 2.1 | n/a | 4.5 | 6.2 | 9.1 | 25.5 | 12.6 | 12.3 | 5.3 | 21.3 | 21.8 | 16.1 |
| Free cash flow | -58.9 | 201 | -34.4 | -21.4 | -30.0 | -204 | -144 | -109 | -111 | n/a | -154 | -126 | -124 | -142 | -163 | 139 | -137 | -159 | -815 | 549 |
| Buybacks | 0.0 | 0.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
| Shares outstanding | 141m | 141m | 142m | 142m | 142m | 142m | 143m | 143m | 143m | 144m | 146m | 146m | 158m | 158m | 159m | 159m | 161m | 163m | 166m | 166m |
| Filing | 10-Q | 10-K | 10-Q | 10-Q | 10-Q | 10-K | 10-Q | 10-Q | 10-Q | 10-K | 10-Q | 10-Q | 10-Q | 10-K | 10-Q | 10-Q | 10-Q | 10-K | 10-Q | 10-Q |
Each quarter as filed, linked to its filing.
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Money is in $ million as the company files it, or in $ billion by the switch above the tables; per share figures and the share count are as they are. Free cash flow is operating cash flow less capital expenditure; the effective tax rate is income tax over pre-tax income; margins are the line over revenue. Gross profit is revenue less cost of revenue, and operating income is revenue less the company's own total costs, where the statement does not print those lines. Cash flow lines filed year to date are the difference between two filings. Shares outstanding are at the period end where the balance sheet tags them, otherwise the count on the filing's cover page. A derived fourth-quarter EPS is left blank when a split in the year makes the arithmetic meaningless.Income statement (profit and loss), 18 fiscal years and the trailing twelve months
Play it forward: change any box and its column follows; every box opens at the company's own record, shown under the row's name, and says when you set it outside every year in the table.
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Each column runs from the last twelve months as filed to the year chosen in its heading, at a yearly rate. Sales growth starts at the company's own five-year rate and eases a third of the way each year toward the median of the 99 peers in Pharmaceutical Products (13.2% a year), because a rate far from the rest rarely lasts. Before you open a year, the strip reads today's price backwards: the yearly sales growth that brings EPS, at the company's own margins, tax and share count, to today's price at the median P/E of the 54 peers in Pharmaceutical Products (26.9). Low, middle, high opens three columns for one year: the low and high cases take the company's own weaker and stronger years in the table (the lower and upper quarter of its yearly sales growth and operating margin) and the lower and higher of today's P/E and its peers'; the middle is the boxes as they open. Net income keeps the share that went to minority holders; EPS is net income over the diluted shares, on the same basis as the EPS in the table. The price is that year's EPS at the P/E you set, and the yearly return runs from today's price to the year's end. These are your assumptions and your arithmetic, not an estimate of ours. The link carries your columns, so you can send the forecast to someone.| FY2008 | FY2009 | FY2010 † | FY2011 † | FY2012 † | FY2013 | FY2014 | FY2015 † | FY2016 † | FY2017 † | FY2018 † | FY2019 † | FY2020 † | FY2021 | FY2022 | FY2023 † | FY2024 | FY2025 | TTM | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | 107 | 122 | 108 | 99.1 | 102 | 147 | 214 | 284 | 373 | 514 | 600 | 1,123 | 729 | 810 | 587 | 788 | 705 | 944 | 874 |
| Cost of revenue | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 0.0 | 0.0 | 1.8 | 4.4 | 11.9 | 10.8 | 14.1 | 9.1 | 11.2 | 15.9 | 16.0 |
| Gross profit | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 373 | 514 | 598 | 1,118 | 717 | 800 | 573 | 779 | 694 | 928 | 858 |
| Gross margin | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 100.0% | 100.0% | 99.7% | 99.6% | 98.4% | 98.7% | 97.6% | 98.8% | 98.4% | 98.3% | 98.2% |
| Research and development | 106 | 135 | 145 | 153 | 155 | 174 | 239 | 320 | 340 | 372 | 412 | 462 | 531 | 638 | n/a | 900 | 902 | 916 | n/a |
| Selling, general and administrative | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 37.2 | 48.6 | 108 | 245 | 287 | 354 | 186 | 150 | 233 | 267 | 394 | 528 |
| Operating income | -13.1 | -27.5 | -48.4 | -71.1 | -68.9 | -51.7 | -47.7 | -75.8 | -20.2 | 31.0 | -61.4 | 366 | -172 | -30.2 | -410 | -354 | -475 | -382 | -594 |
| Operating margin | -12.2% | -22.6% | -44.6% | -71.8% | -67.5% | -35.1% | -22.3% | -26.7% | -5.4% | 6.0% | -10.2% | 32.6% | -23.6% | -3.7% | -69.8% | -44.9% | -67.4% | -40.4% | -68.0% |
| Interest expense | 11.8 | 12.7 | 13.2 | 16.7 | 21.2 | 19.4 | 22.2 | 36.7 | 38.8 | 44.8 | 44.8 | 12.4 | 9.5 | 9.3 | 8.1 | 12.7 | 17.0 | 17.3 | 18.8 |
| Pre-tax income | n/a | -31.8 | -61.2 | -84.8 | -74.6 | -66.6 | -54.4 | -87.9 | -83.6 | -16.8 | -76.2 | 339 | -135 | -29.1 | -258 | -334 | -460 | -380 | -562 |
| Income tax | n/a | 3.2 | 0.1 | 0.0 | -9.1 | -5.9 | -15.4 | 0.4 | 2.9 | -6.0 | -291 | 51.5 | 345 | -0.6 | 11.7 | 32.3 | -6.2 | 1.8 | 3.2 |
| Effective tax rate | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 15.2% | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
| Net income | -18.2 | 155 | -61.3 | -84.8 | -65.5 | -60.6 | -39.0 | -88.3 | -60.4 | 0.3 | 274 | 278 | -444 | -28.6 | -270 | -366 | -454 | -381 | -565 |
| Net margin | -17.0% | 127.5% | -56.5% | -85.6% | -64.2% | -41.2% | -18.2% | -31.1% | -16.2% | 0.1% | 45.6% | 24.8% | -60.9% | -3.5% | -45.9% | -46.5% | -64.4% | -40.4% | -64.7% |
| Diluted EPS | -$0.15 | $1.26 | -$0.50 | -$0.68 | -$0.52 | -$0.44 | -$0.26 | -$0.59 | -$0.40 | $0.06 | $1.66 | $1.90 | -$3.18 | -$0.20 | -$1.90 | -$2.56 | -$3.04 | -$2.38 | -$3.46 |
| Filing | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
From each year's 10-K, linked; TTM is the last four quarters.
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Free cash flow is operating cash flow less capital expenditure; the effective tax rate is income tax over pre-tax income; margins are the line over revenue. Gross profit is revenue less cost of revenue, and operating income is revenue less the company's own total costs, where the statement does not print those lines. Those four are arithmetic on the filed numbers; everything else is as filed. Money is in $ million as the company files it, or in $ billion by the switch above the tables; per share figures and share counts are as they are. † The year as the company last restated it in a later filing; rest on a figure for the one first filed. EPS is as filed.Cash flow and capital returned
Follow the cash: free cash flow, which is operating cash flow less capital expenditure and share-based pay, for five years and after, in today's money.
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The figure a share at the top is what a discounted cash flow calls intrinsic value, worked out on your assumptions. Everything after year five is one sum: the sixth year's cash, growing at the long-run rate every year after, added up and brought back to today's money. Each year runs from the last twelve months as filed. Sales growth opens where Play it forward does: the company's own five-year rate, easing a third of the way each year toward the median of the 99 peers in Pharmaceutical Products (13.2% a year); change a year and the years after it follow. Operating cash flow, capital expenditure and share-based pay open at the company's own median share of sales over its last five years, shown under each row. Share-based pay is taken off because operating cash flow adds back the shares paid to staff as if they cost nothing; set it to 0 to leave it in. Capital spending counts every capital line the company files in its cash flow, such as equipment it leases to customers, software, wells or property it develops, named under the row, while the Capital expenditure row in the table below stays the one line as filed; buying a business, securities or a finished property is not counted. The discount rate opens at 10%, about what US stocks have returned a year over the long run, so it is the return you give up by holding this company instead of the market; the growth after year five opens at 3%, a little under the US economy's long-run growth in dollars, because no company outgrows it for ever. Net debt is the debt and short-term borrowings less the cash on the latest balance sheet that shows the debt; the figure per share divides what is left by the diluted share count. These are your assumptions and your arithmetic, not an estimate of ours. The link carries them, so you can send them to someone.| FY2008 | FY2009 | FY2010 † | FY2011 † | FY2012 † | FY2013 | FY2014 | FY2015 † | FY2016 † | FY2017 † | FY2018 † | FY2019 † | FY2020 † | FY2021 | FY2022 | FY2023 † | FY2024 | FY2025 | TTM | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating cash flow | 212 | -108 | -63.6 | -115 | 1.9 | 63.5 | 6.3 | 21.1 | -112 | 174 | 603 | 346 | 35.9 | 30.8 | -274 | -308 | -501 | -269 | -496 |
| Capital expenditure | 13.7 | 13.4 | 13.2 | 10.2 | 1.5 | 1.6 | 7.5 | 7.7 | 7.1 | 34.8 | 13.6 | 30.9 | 35.1 | 12.0 | 15.7 | 23.8 | 45.3 | 51.4 | 64.4 |
| Free cash flow | 198 | -122 | -76.8 | -125 | 0.4 | 61.9 | -1.2 | 13.4 | -119 | 139 | 589 | 315 | 0.8 | 18.8 | -290 | -331 | -546 | -320 | -561 |
| Free cash flow margin | 185.1% | -100.2% | -70.8% | -126.2% | 0.4% | 42.1% | -0.6% | 4.7% | -32.0% | 27.1% | 98.3% | 28.0% | 0.1% | 2.3% | -49.4% | -42.1% | -77.5% | -33.9% | -64.2% |
| Cash from investing | -234 | -212 | 23.7 | 111 | n/a | n/a | n/a | -60.1 | 56.6 | -358 | -930 | -41.3 | 274 | 195 | -263 | -214 | -134 | -278 | 232 |
| Cash from financing | 108 | 202 | 4.7 | -0.7 | n/a | n/a | n/a | 24.7 | 11.4 | 229 | 476 | 100 | -597 | 246 | -55.3 | 644 | 478 | 676 | 317 |
| Depreciation and amortisation | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 9.0 | 8.3 | 12.5 | 14.5 | 15.4 | 17.8 | 16.7 | 12.9 | 11.9 | 12.4 | 14.9 |
| Share-based compensation | 15.1 | 13.4 | 12.2 | 9.8 | 8.6 | 11.4 | 31.4 | 59.3 | 72.1 | 86.0 | 131 | 147 | 230 | 121 | 100 | 106 | 130 | 134 | 163 |
| Buybacks | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 0.0 | 0.0 | 34.4 | 90.5 | 0.0 | 0.0 | n/a | n/a | n/a | n/a |
| Diluted shares, weighted | 118m | 123m | 124m | 125m | 126m | 138m | n/a | 150m | 151m | 126m | 168m | 153m | 140m | 141m | 142m | 143m | 150m | 160m | 165m |
| Shares outstanding at period end | n/a | 124m | 124m | 125m | 127m | 146m | 148m | 150m | 152m | 156m | 172m | 140m | 140m | 141m | 142m | 144m | 158m | 163m | 166m |
| Filing | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
Cash paid in the year, from the cash flow statement.
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The dividend per share is as declared. Diluted shares are the weighted average for the year; a falling count is the buybacks net of issuance. TTM sums the last four quarters; the share counts are the latest quarter's.Balance sheet at year end
| FY2008 | FY2009 | FY2010 † | FY2011 † | FY2012 † | FY2013 | FY2014 | FY2015 † | FY2016 † | FY2017 † | FY2018 † | FY2019 † | FY2020 † | FY2021 | FY2022 | FY2023 † | FY2024 | FY2025 | TTM | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Funded by | |||||||||||||||||||
| Shareholders' equity | 147 | 292 | 245 | 171 | 183 | 378 | 258 | 201 | 99.6 | 281 | 1,048 | 1,471 | 743 | 772 | 573 | 387 | 588 | 489 | 440 |
| Non-controlling interest | n/a | 10.3 | n/a | n/a | n/a | n/a | n/a | n/a | 0.0 | 84.3 | 139 | 213 | 0.0 | n/a | n/a | n/a | n/a | n/a | n/a |
| Debt | n/a | 11.5 | 149 | 146 | 144 | 150 | n/a | n/a | 501 | 533 | 568 | 786 | 940 | 1,221 | 1,194 | 1,308 | 1,253 | 1,812 | 1,323 |
| Operating lease liabilities | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 19.4 | 179 | 171 | 162 | 262 | 262 |
| Other liabilities | n/a | 344 | 157 | 168 | 219 | 318 | 698 | 747 | 312 | 424 | 912 | 763 | 707 | 599 | 588 | 1,124 | 1,000 | 960 | 970 |
| Total liabilities and equity | n/a | 657 | 550 | 485 | 546 | 847 | 956 | 948 | 912 | 1,322 | 2,668 | 3,233 | 2,390 | 2,612 | 2,534 | 2,990 | 3,004 | 3,524 | 2,995 |
| Owned | |||||||||||||||||||
| Fixed assets | n/a | 27.3 | 35.7 | 96.6 | 91.1 | 86.2 | 89.0 | 90.2 | 92.8 | 122 | 132 | 154 | 181 | 178 | 74.3 | 71.0 | 94.3 | 123 | 155 |
| Intangible assets | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 20.4 | 22.0 | 24.0 | 25.7 | 27.9 | 29.0 | n/a | n/a | n/a | n/a | n/a |
| Investments | n/a | 469 | 402 | 278 | 250 | 497 | 586 | 650 | 581 | 893 | 1,805 | 1,816 | 1,495 | 1,881 | 2,220 | 2,585 | 2,708 | 3,079 | 2,352 |
| Cash and equivalents | 224 | 105 | 70.1 | 65.5 | 124 | 160 | 143 | 129 | 84.7 | 130 | 279 | 683 | 398 | 869 | 276 | 399 | 242 | 372 | 350 |
| Inventory | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 10.0 | 8.6 | 18.2 | 22.0 | 24.8 | 22.0 | 7.4 | 12.5 | 10.0 | 50.8 |
| Other assets | n/a | 55.5 | 42.4 | 44.6 | 80.2 | 104 | 138 | 78.5 | 134 | 145 | 419 | 536 | 266 | n/a | n/a | n/a | n/a | n/a | 86.6 |
| Total assets | n/a | 657 | 550 | 485 | 546 | 847 | 956 | 948 | 912 | 1,322 | 2,668 | 3,233 | 2,390 | 2,612 | 2,534 | 2,990 | 3,004 | 3,524 | 2,995 |
| Filing | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | |
At the fiscal year end; the TTM column is the latest quarter end.
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Both totals are the company's own. Other liabilities is the filed total less the rows above it: payables, deferred revenue, taxes, borrowings the rows above do not carry and the rest; other assets is the same on the other side. Investments add the current and non-current lines as filed. Debt is the company's own stated total where it files one, otherwise its long-term debt with the current maturities, never parts added together. A row is left blank in a year where the lines shown overlap and the remainder would fall below nil.Compounded growth
| 10 years | 5 years | 3 years | TTM | |
|---|---|---|---|---|
| Sales growth, compounded | 12.8% | 5.3% | 17.1% | -7.4% |
| Profit growth, compounded | n/a | n/a | n/a | n/a |
| Return on equity, average | -37.6% | -60.1% | -83.3% | -78.0% |
Yearly growth, compounded; TTM is the last four quarters against the four before.
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Return on equity is net income over shareholders' equity at each year end, averaged over the window (the TTM column is the latest year alone); equity is the parent's shareholders' equity as tagged in the 10-K. Arithmetic on filed numbers, nothing forecast.Questions
What was Ionis Pharmaceuticals' revenue in fiscal 2025?
Ionis Pharmaceuticals (IONS) reported revenue of $944 million for fiscal 2025, the year ended 31 December 2025, up 33.8% on the year before.
How much did Ionis Pharmaceuticals earn in fiscal 2025?
Net loss was $381 million for fiscal 2025, and the diluted loss per share $2.38.
What is Ionis Pharmaceuticals' market cap?
The market cap of Ionis Pharmaceuticals was $7.3 billion at the close of 27 October 2026.
How much debt does Ionis Pharmaceuticals have?
At 30 June 2026 Ionis Pharmaceuticals carried $1.3 billion of debt and $350 million of cash.
Peers: Pharmaceutical Products
| Company | Market cap | P/E | ROE | Op. margin | Sales growth TTM | Debt to equity | Div. yield |
|---|---|---|---|---|---|---|---|
| Eli Lilly & Co. LLY | $1.21 trillion | 43.02 | 78.8% | n/a | 49.6% | 1.62 | 0.5% |
| Johnson & Johnson JNJ | $646.9 billion | 40.72 | 19.7% | n/a | 7.8% | 0.55 | 2.0% |
| AbbVie Inc. ABBV | $506.2 billion | 80.92 | n/a | 26.2% | 10.4% | n/a | 2.4% |
| Merck & Co., Inc. MRK | $349.9 billion | 113.46 | 7.6% | n/a | 4.6% | 1.29 | 2.4% |
| Novartis AG NVS * | $299.2 billion | 21.93 | 30.3% | n/a | 8.4% | 0.62 | 2.6% |
| AstraZeneca PLC AZN * | $263.7 billion | 26.00 | 21.0% | 23.4% | 8.6% | 0.57 | 1.9% |
| Abbott Laboratories ABT | $178.5 billion | 33.38 | 10.6% | 15.8% | 8.1% | 0.64 | 2.4% |
| Novo Nordisk A/S NVO * | $172.7 billion | 11.20 | 52.8% | 41.3% | 6.4% | 0.67 | 4.5% |
| Pfizer Inc. PFE | $169.8 billion | 39.20 | 5.1% | n/a | -0.2% | 0.74 | 5.8% |
| Vertex Pharmaceuticals Inc. VRTX | $132.0 billion | 30.33 | 21.8% | 38.0% | 10.2% | 0.00 | n/a |
| Bristol-Myers Squibb Co. BMY | $125.8 billion | 13.56 | 41.6% | 24.2% | 3.1% | 1.93 | 4.1% |
| GSK plc GSK * | $102.3 billion | 13.73 | 34.9% | 24.3% | 4.1% | 1.08 | 3.3% |
All 126 in Pharmaceutical Products
| Company | Market cap | P/E | ROE | Op. margin | Sales growth TTM | Debt to equity | Div. yield |
|---|---|---|---|---|---|---|---|
| Eli Lilly & Co. LLY | $1.21 trillion | 43.02 | 78.8% | n/a | 49.6% | 1.62 | 0.5% |
| Johnson & Johnson JNJ | $646.9 billion | 40.72 | 19.7% | n/a | 7.8% | 0.55 | 2.0% |
| AbbVie Inc. ABBV | $506.2 billion | 80.92 | n/a | 26.2% | 10.4% | n/a | 2.4% |
| Merck & Co., Inc. MRK | $349.9 billion | 113.46 | 7.6% | n/a | 4.6% | 1.29 | 2.4% |
| Novartis AG NVS * | $299.2 billion | 21.93 | 30.3% | n/a | 8.4% | 0.62 | 2.6% |
| AstraZeneca PLC AZN * | $263.7 billion | 26.00 | 21.0% | 23.4% | 8.6% | 0.57 | 1.9% |
| Amgen Inc. AMGN | $242.2 billion | 27.84 | 74.8% | 30.0% | 9.1% | 4.90 | 2.2% |
| Gilead Sciences, Inc. GILD | $197.4 billion | n/a | -27.4% | -8.2% | 5.5% | 2.22 | 2.0% |
| Abbott Laboratories ABT | $178.5 billion | 33.38 | 10.6% | 15.8% | 8.1% | 0.64 | 2.4% |
| Novo Nordisk A/S NVO * | $172.7 billion | 11.20 | 52.8% | 41.3% | 6.4% | 0.67 | 4.5% |
| Pfizer Inc. PFE | $169.8 billion | 39.20 | 5.1% | n/a | -0.2% | 0.74 | 5.8% |
| Vertex Pharmaceuticals Inc. VRTX | $132.0 billion | 30.33 | 21.8% | 38.0% | 10.2% | 0.00 | n/a |
| Bristol-Myers Squibb Co. BMY | $125.8 billion | 13.56 | 41.6% | 24.2% | 3.1% | 1.93 | 4.1% |
| GSK plc GSK * | $102.3 billion | 13.73 | 34.9% | 24.3% | 4.1% | 1.08 | 3.3% |
| Sanofi SNY * | $102.2 billion | 11.74 | 10.9% | n/a | 6.2% | 0.26 | 5.3% |
| Regeneron Pharmaceuticals, Inc. REGN | $86.5 billion | 20.17 | 13.7% | 24.7% | 9.3% | 0.06 | 0.4% |
| Moderna, Inc. MRNA | $82.9 billion | n/a | -46.6% | -149.0% | -27.6% | 0.09 | n/a |
| Takeda Pharmaceutical Company Limited TAK * | $64.1 billion | n/a | -2.1% | 0.1% | -1.7% | 0.66 | 3.2% |
| argenx SE ARGX * | $54.6 billion | 45.08 | 17.6% | n/a | 89.9% | 0.00 | n/a |
| Teva Pharmaceutical Industries Ltd. TEVA | $47.1 billion | 67.35 | 9.1% | 9.3% | 4.1% | 2.14 | 0.0% |
| IDEXX Laboratories Inc. IDXX | $44.3 billion | 39.46 | 70.7% | 32.0% | 12.8% | 0.60 | n/a |
| Biogen Inc. BIIB | $37.3 billion | 44.70 | 4.4% | 10.1% | 0.3% | 0.43 | n/a |
| Royalty Pharma plc RPRX | $36.4 billion | 34.91 | 8.3% | 59.6% | 10.0% | 0.92 | 1.4% |
| Zoetis Inc. ZTS | $32.4 billion | 12.89 | 83.1% | n/a | 1.5% | 2.87 | 2.6% |
| Alnylam Pharmaceuticals, Inc. ALNY | $30.3 billion | 42.14 | 59.7% | 20.8% | 95.1% | 0.75 | n/a |
| Genmab A/S GMAB * | $28.7 billion | 29.06 | 16.5% | 28.6% | 19.2% | 0.90 | n/a |
| Roivant Sciences Ltd. ROIV | $26.4 billion | n/a | -6.3% | -7,914.8% | -67.6% | 0.00 | n/a |
| United Therapeutics Corp. UTHR | $25.2 billion | 21.16 | 20.5% | 44.4% | 2.5% | 0.00 | n/a |
| BioNTech SE BNTX * | $21.9 billion | n/a | -5.9% | -49.0% | 4.3% | 0.01 | n/a |
| Viatris Inc. VTRS | $21.5 billion | n/a | -2.9% | -0.6% | 4.4% | 0.94 | 2.6% |
| Insmed Inc. INSM | $20.7 billion | n/a | -115.6% | -73.9% | 185.8% | 0.72 | n/a |
| Exelixis, Inc. EXEL | $16.3 billion | 20.55 | 46.7% | 39.9% | 9.2% | 0.00 | n/a |
| Neurocrine Biosciences Inc. NBIX | $14.8 billion | 21.42 | 19.1% | 23.6% | 34.4% | 0.00 | n/a |
| Halozyme Therapeutics, Inc. HALO | $14.7 billion | 38.36 | 288.1% | 35.9% | 41.2% | 14.95 | n/a |
| BridgeBio Pharma, Inc. BBIO | $13.6 billion | n/a | n/a | -69.8% | 202.4% | n/a | n/a |
| Jazz Pharmaceuticals plc JAZZ | $13.4 billion | 14.26 | 19.6% | 19.5% | 12.6% | 0.91 | n/a |
| Dr. Reddy’s Laboratories Limited RDY * | $11.5 billion | 25.37 | 11.4% | 15.0% | 3.2% | 0.21 | 0.7% |
| Bio-Techne Corp. TECH | $11.3 billion | 63.14 | 8.6% | 20.7% | -0.4% | 0.09 | 0.4% |
| Elanco Animal Health Inc. ELAN | $11.3 billion | n/a | -3.0% | n/a | 12.0% | 0.56 | n/a |
| Biomarin Pharmaceutical Inc. BMRN | $10.7 billion | 149.59 | 1.2% | 4.4% | 11.2% | 0.66 | n/a |
| Madrigal Pharmaceuticals, Inc. MDGL | $10.2 billion | n/a | -62.1% | -25.1% | 149.0% | 0.65 | n/a |
| Twist Bioscience Corp. TWST | $10.0 billion | n/a | -30.7% | -33.6% | 19.2% | 0.03 | n/a |
| Repligen Corp. RGEN | $9.9 billion | 240.84 | 2.0% | 8.2% | 16.5% | 0.26 | n/a |
| Kymera Therapeutics, Inc. KYMR | $9.7 billion | n/a | -19.9% | -333.5% | 134.8% | 0.00 | n/a |
| Krystal Biotech, Inc. KRYS | $9.5 billion | 40.18 | 17.8% | 44.9% | 22.6% | 0.00 | n/a |
| Corcept Therapeutics Inc. CORT | $9.5 billion | 208.58 | 7.8% | 0.8% | 16.0% | 0.00 | 0.0% |
| Protagonist Therapeutics, Inc. PTGX | $9.1 billion | 136.96 | 9.9% | 20.7% | 34.8% | 0.00 | n/a |
| ImmunityBio, Inc. IBRX | $9.1 billion | n/a | n/a | -151.9% | 192.9% | n/a | n/a |
| TG Therapeutics, Inc. TGTX | $8.6 billion | 20.61 | 73.1% | 17.1% | 76.1% | 1.23 | n/a |
| Cytokinetics Inc. CYTK | $8.6 billion | n/a | n/a | -1,046.1% | -21.1% | n/a | n/a |
| Arrowhead Pharmaceuticals, Inc. ARWR | $8.3 billion | n/a | -68.7% | -33.8% | 16.8% | 1.86 | n/a |
| Axsome Therapeutics, Inc. AXSM | $7.4 billion | n/a | -230.1% | -24.0% | 56.9% | 2.26 | n/a |
| Alkermes plc. ALKS | $7.4 billion | 116.67 | 3.7% | 7.0% | 10.8% | 0.84 | n/a |
| Ionis Pharmaceuticals Inc. IONS | $7.3 billion | n/a | -128.5% | -68.0% | -7.4% | 3.01 | n/a |
| Amneal Pharmaceuticals, Inc. AMRX | $6.8 billion | 43.76 | 476.5% | 14.6% | 9.3% | 80.86 | n/a |
| Iovance Biotherapeutics, Inc. IOVA | $6.6 billion | n/a | -39.3% | -92.7% | 34.5% | 0.00 | n/a |
| Lantheus Holdings, Inc. LNTH | $6.5 billion | 24.19 | 21.0% | 19.4% | 2.3% | 0.43 | n/a |
| Rhythm Pharmaceuticals, Inc. RYTM | $6.3 billion | n/a | -199.4% | -83.6% | 53.5% | 1.03 | n/a |
| Ligand Pharmaceuticals Inc. LGND | $6.2 billion | 33.31 | 20.4% | 32.6% | 54.9% | 1.16 | n/a |
| CG Oncology, Inc. CGON | $5.6 billion | n/a | -21.8% | -4,056.2% | 1,030.3% | 0.00 | n/a |
| Mirum Pharmaceuticals, Inc. MIRM | $5.5 billion | n/a | n/a | -134.9% | 44.0% | n/a | n/a |
| PTC Therapeutics, Inc. PTCT | $5.2 billion | n/a | n/a | 12.5% | -42.8% | n/a | n/a |
| Scholar Rock Holding Corp. SRRK | $5.2 billion | n/a | n/a | n/a | n/a | 0.77 | n/a |
| Crispr Therapeutics AG CRSP | $5.0 billion | n/a | -25.8% | -3,990.0% | -64.8% | 0.34 | n/a |
| Travere Therapeutics, Inc. TVTX | $4.8 billion | n/a | -177.2% | -6.8% | 77.1% | 24.58 | n/a |
| Gossamer Bio, Inc. GOSS | $4.7 billion | n/a | n/a | -311.7% | 32.4% | n/a | n/a |
| Adaptive Biotechnologies Corp. ADPT | $4.4 billion | n/a | -44.7% | -12.2% | 50.1% | 2.34 | n/a |
| Relay Therapeutics, Inc. RLAY | $4.1 billion | n/a | -32.1% | -2,999.7% | 23.9% | 0.00 | n/a |
| Indivior Pharmaceuticals, Inc. INDV | $4.1 billion | n/a | n/a | n/a | 13.5% | n/a | n/a |
| Liquidia Corp. LQDA | $4.0 billion | 33.16 | 71.0% | 37.4% | 2,233.6% | n/a | n/a |
| Arcutis Biotherapeutics, Inc. ARQT | $4.0 billion | 150.79 | 12.9% | 7.4% | 76.1% | 0.49 | n/a |
| AbCellera Biologics Inc. ABCL | $3.9 billion | n/a | -18.4% | -340.2% | 101.3% | 0.00 | n/a |
| Tango Therapeutics, Inc. TNGX | $3.9 billion | n/a | -12.1% | -253.4% | 121.5% | 0.00 | n/a |
| Organon & Co. OGN | $3.6 billion | 17.85 | 20.8% | n/a | -2.5% | 8.50 | 0.6% |
| Xenon Pharmaceuticals Inc. XENE | $3.5 billion | n/a | -32.9% | n/a | n/a | 0.00 | n/a |
| Acadia Pharmaceuticals Inc. ACAD | $3.5 billion | 9.08 | 29.1% | 7.6% | 11.8% | 0.00 | n/a |
| Ideaya Biosciences, Inc. IDYA | $3.2 billion | n/a | n/a | n/a | n/a | 0.00 | n/a |
| Denali Therapeutics Inc. DNLI | $3.1 billion | n/a | n/a | n/a | n/a | 0.00 | n/a |
| Tarsus Pharmaceuticals, Inc. TARS | $3.1 billion | n/a | -13.4% | -8.0% | 105.2% | 0.21 | 0.0% |
| DBV Technologies S.A. DBVT | $3.0 billion | n/a | -109.7% | -3,543.8% | 29.2% | 0.00 | n/a |
| Nurix Therapeutics, Inc. NRIX | $2.9 billion | 11.57 | 30.5% | 41.3% | 738.8% | 0.00 | 0.0% |
| Viking Therapeutics, Inc. VKTX | $2.9 billion | n/a | -131.0% | n/a | n/a | 0.00 | n/a |
| Silence Therapeutics plc SLN | $2.8 billion | n/a | -155.8% | -11,106.8% | -97.7% | 0.00 | n/a |
| Viridian Therapeutics, Inc.\DE VRDN | $2.7 billion | n/a | -58.4% | -569.7% | 23,220.3% | 0.54 | n/a |
| Neogen Corp. NEOG | $2.7 billion | n/a | -2.7% | -0.8% | -0.3% | 0.37 | n/a |
| Beam Therapeutics Inc. BEAM | $2.6 billion | n/a | -8.0% | -242.3% | 158.9% | 0.09 | n/a |
| Adma Biologics, Inc. ADMA | $2.5 billion | 15.98 | 41.4% | 43.8% | 8.0% | 0.48 | n/a |
| NewAmsterdam Pharma Co. N.V. NAMS | $2.4 billion | n/a | -41.1% | -3,432.2% | -88.9% | 0.00 | n/a |
| Supernus Pharmaceuticals, Inc. SUPN | $2.4 billion | n/a | -10.7% | -15.7% | 24.9% | 0.00 | n/a |
| Celldex Therapeutics, Inc. CLDX | $2.4 billion | n/a | -42.1% | -207,534.4% | -97.3% | 0.00 | n/a |
| Bausch Health Companies Inc. BHC | $2.4 billion | n/a | n/a | 8.1% | 10.1% | n/a | 20.3% |
| Arcus Biosciences, Inc. RCUS | $2.3 billion | n/a | -99.1% | -415.4% | -55.3% | 0.22 | n/a |
| Aurinia Pharmaceuticals Inc. AUPH | $2.3 billion | 7.54 | 51.1% | 48.4% | 19.8% | 0.00 | n/a |
| Agios Pharmaceuticals, Inc. AGIO | $2.3 billion | n/a | -40.1% | -466.8% | 140.6% | 0.00 | n/a |
| Prestige Consumer Healthcare Inc. PBH | $2.2 billion | 13.28 | 9.0% | 26.3% | -1.4% | 1.05 | n/a |
| Xencor Inc. XNCR | $2.2 billion | n/a | -32.5% | -205.8% | -28.6% | 0.21 | n/a |
| Perrigo Co. plc PRGO | $2.2 billion | n/a | -69.0% | -37.7% | -4.2% | 1.31 | 7.2% |
| Vericel Corp. VCEL | $2.2 billion | 92.13 | 6.5% | 6.0% | 23.0% | 0.00 | n/a |
| Harmony Biosciences Holdings, Inc. HRMY | $2.2 billion | 12.32 | 18.1% | 24.0% | 24.3% | 0.15 | n/a |
| Precigen, Inc. PGEN | $2.2 billion | n/a | n/a | n/a | n/a | 2.15 | n/a |
| Recursion Pharmaceuticals, Inc. RXRX | $2.2 billion | n/a | -56.7% | -991.7% | -15.1% | 0.02 | n/a |
| Immunome Inc. IMNM | $2.1 billion | n/a | -48.4% | n/a | n/a | 0.00 | n/a |
| Biocryst Pharmaceuticals Inc. BCRX | $2.1 billion | n/a | n/a | -33.3% | 68.7% | n/a | n/a |
| Zymeworks Inc. ZYME | $2.1 billion | n/a | -186.6% | -419.0% | -69.8% | 0.00 | n/a |
| Trulieve Cannabis Corp. TRLV | $2.1 billion | n/a | -61.8% | -24.3% | -3.9% | 0.38 | n/a |
| Septerna, Inc. SEPN | $2.0 billion | n/a | -6.3% | -44.0% | 13,520.1% | 0.00 | n/a |
| Sarepta Therapeutics, Inc. SRPT | $2.0 billion | n/a | -8.9% | -7.3% | -20.4% | 0.55 | n/a |
| Vir Biotechnology, Inc. VIR | $2.0 billion | n/a | -25.6% | -92.4% | 1,495.9% | 0.00 | n/a |
| Xeris Biopharma Holdings, Inc. XERS | $1.8 billion | n/a | n/a | 10.9% | 36.3% | n/a | n/a |
| Maze Therapeutics, Inc. MAZE | $1.8 billion | n/a | n/a | n/a | n/a | 0.09 | n/a |
| Zenas BioPharma, Inc. ZBIO | $1.7 billion | n/a | n/a | n/a | n/a | 1.20 | n/a |
| Intellia Therapeutics, Inc. NTLA | $1.7 billion | n/a | -55.0% | -711.7% | 12.6% | 0.00 | n/a |
| Schrodinger, Inc. SDGR | $1.7 billion | n/a | -16.5% | -59.2% | 8.9% | 0.00 | n/a |
| UroGen Pharma Ltd. URGN | $1.7 billion | n/a | n/a | -35.3% | 100.3% | n/a | n/a |
| Ultragenyx Pharmaceutical Inc. RARE | $1.7 billion | n/a | n/a | -73.6% | 17.5% | n/a | n/a |
| Novavax Inc. NVAX | $1.7 billion | n/a | n/a | -56.6% | -61.6% | n/a | n/a |
| Immunocore Holdings plc IMCR | $1.6 billion | n/a | -4.3% | -5.2% | 21.0% | 0.94 | 0.0% |
| Stoke Therapeutics, Inc. STOK | $1.6 billion | n/a | -60.2% | -809.7% | -86.2% | 0.00 | n/a |
| ANI Pharmaceuticals Inc. ANIP | $1.6 billion | 15.13 | 18.1% | 15.4% | 30.9% | 1.02 | n/a |
| Nuvation Bio Inc. NUVB | $1.6 billion | n/a | -59.0% | -81.0% | 1,083.6% | 0.98 | n/a |
| Phibro Animal Health Corp. PAHC | $1.6 billion | 15.78 | 25.9% | 12.8% | 17.1% | 1.91 | 1.3% |
| Innoviva, Inc. INVA | $1.5 billion | 5.11 | 29.0% | 36.9% | 18.8% | 0.21 | 0.0% |
| Pacira BioSciences, Inc. PCRX | $1.4 billion | 104.00 | 2.2% | 2.7% | 5.7% | 0.54 | n/a |
| Amphastar Pharmaceuticals, Inc. AMPH | $1.1 billion | 15.13 | 10.2% | 15.7% | 1.0% | 0.79 | n/a |
| QuidelOrtho Corp. QDEL | $928 million | n/a | -59.1% | -30.8% | -2.5% | 1.63 | n/a |
| Collegium Pharmaceutical, Inc. COLL | $748 million | 18.56 | 15.4% | 19.5% | 14.3% | 3.50 | n/a |
85 companies share its SEC industry code (Pharmaceutical Preparations); the rest are the names nearest in size in its wider industry, Pharmaceutical Products, one of the Fama-French 48 industries, a published grouping of SEC industry codes.
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By market capitalisation; a click on a heading sorts by it, largest first, and a second click turns it round. Each figure is the same arithmetic as the ratio box above, on each company's own filings and latest close; a name marked * is a foreign company that files once a year, on its latest fiscal year.Filings
| Filing | Period | Filed | Where |
|---|---|---|---|
| 10-Q | 30 June 2026 | 29 July 2026 | EDGAR |
| 10-Q | 31 March 2026 | 29 April 2026 | EDGAR |
| 10-K | 31 December 2025 | 26 February 2026 | EDGAR |
| 10-Q | 30 September 2025 | 29 October 2025 | EDGAR |
| 10-Q | 30 June 2025 | 30 July 2025 | EDGAR |
| 10-Q | 31 March 2025 | 30 April 2025 | EDGAR |
| 10-K | 31 December 2024 | 19 February 2025 | EDGAR |
| 10-Q | 30 September 2024 | 6 November 2024 | EDGAR |
| 10-Q | 30 June 2024 | 1 August 2024 | EDGAR |
| 10-Q | 31 March 2024 | 7 May 2024 | EDGAR |