Ionis Pharmaceuticals Inc. 13F holders
516 funds reported a position in Ionis Pharmaceuticals Inc. in their 13F for the quarter ended 30 June 2026, together 179.8 million shares worth $14.27 billion. Against the quarter before, 51 opened a position, 199 added, 162 trimmed and 45 sold out; together they bought a net 7.0 million shares. The largest holders: FMR LLC, Capital World Investors and BlackRock, Inc.
Funds holding516+18 on Q1 2026
Shares they held179.8Mworth $14.27 billion
Net bought on the quarter7.0M sharesabout $554.0 million at the funds' values
Funds buying to selling250 to 207opened or added, to cut or sold
Opened 51Added 199Held 100Trimmed 162Sold out 45
What each fund did in IONS against its 13F for the quarter before; a change under 0.1% of a holding counts as held
Funds reporting a position in IONS in their 13F, each quarter; hover a bar for the shares they held
Filed so far for the quarter to 30 September 2026
2,671 funds have filed their 13F for the quarter so far; the rest are due by 16 November 2026. Of those, 66 reported a position in Ionis Pharmaceuticals Inc.: 9 opened one, 16 added, 19 trimmed and 31 sold out, a net 430,862 shares sold.
The largest moves in the name among the funds that have filed, against each fund's previous 13F.
The well-known funds
Of the 44 funds followed here, 10 reported a position in Ionis Pharmaceuticals Inc. in a 13F for the quarter ended 30 June 2026. The largest: FMR LLC, 24.6 million shares worth $1.95 billion, 0.1% of its reported book. In the quarter, 6 funds added or opened a position and 3 trimmed or sold out; together they sold a net 179,554 shares, about $14.2 million at the funds' own value per share on 30 June 2026. A change under 0.1% of a holding counts as held.
| Fund | Shares | Value | Of its book | Change on the quarter | Status | Quarter ended | Filing |
|---|---|---|---|---|---|---|---|
| FMR LLC | 24,631,956 | $1.95 billion | 0.1% | +75,319 | added | 30 June 2026 | 13F |
| Two Sigma Investments | 6,252,342 | $495.7 million | 0.4% | +394,713 | added | 30 June 2026 | 13F |
| Geode Capital Management | 3,584,024 | $294.8 million | 0.0% | -400,308 | trimmed | 30 June 2026 | 13F |
| Alyeska | 1,417,916 | $112.4 million | 0.3% | +944,766 | added | 30 June 2026 | 13F |
| Renaissance Technologies | 559,414 | $44.4 million | 0.1% | +253,865 | added | 30 June 2026 | 13F |
| Capital Research Global Investors | 331,936 | $26.3 million | 0.0% | +8,921 | added | 30 June 2026 | 13F |
| ARK Investment Management | 300,770 | $23.8 million | 0.2% | +12,054 | added | 30 June 2026 | 13F |
| Millennium Management | 288,872 | $22.9 million | 0.0% | -762,634 | trimmed | 30 June 2026 | 13F |
| Citadel Advisors | 236,284 | $18.7 million | 0.0% | -706,250 | trimmed | 30 June 2026 | 13F |
| Norges Bank | 114,359 | $9.1 million | 0.0% | held | 30 June 2026 | 13F |
Value is what the fund reported.
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Change is shares against the fund's previous 13F; a fund with one filing read shows no change. 13Fs cover long US positions of managers above $100 million and are filed up to 45 days after the quarter.The largest holders
| Fund | Shares | Share of all | Value | Of its book | Change in shares | Filing |
|---|---|---|---|---|---|---|
| FMR LLC | 24,631,956 | 13.70% | $1.95 billion | 0.09% | +75,319 | 13F |
| Capital World Investors | 21,669,226 | 12.05% | $1.72 billion | 0.20% | +482,857 | 13F |
| BlackRock, Inc. | 10,704,660 | 5.96% | $848.8 million | 0.01% | +262,184 | 13F |
| Vanguard Portfolio Management LLC | 7,859,529 | 4.37% | $623.2 million | 0.03% | +50,627 | 13F |
| Wellington Management Group LLP | 7,651,415 | 4.26% | $606.7 million | 0.10% | +1,259,599 | 13F |
| Vanguard Capital Management LLC | 7,211,497 | 4.01% | $571.8 million | 0.01% | +93,167 | 13F |
| Two Sigma Investments, LP | 6,252,342 | 3.48% | $495.7 million | 0.39% | +394,713 | 13F |
| Royal Bank of Canada | 6,182,479 | 3.44% | $490.2 million | 0.08% | +2,380,664 | 13F |
| State Street Corp. | 4,334,848 | 2.41% | $343.7 million | 0.01% | +339,284 | 13F |
| T. Rowe Price Investment Management, Inc. | 3,959,372 | 2.20% | $313.9 million | 0.21% | -2,199,655 | 13F |
| Geode Capital Management, LLC | 3,584,024 | 1.99% | $294.8 million | 0.02% | -400,308 | 13F |
| Price T Rowe Associates Inc. | 3,184,500 | 1.77% | $252.5 million | 0.03% | +159,249 | 13F |
| JPMorgan Chase & Co. | 2,671,717 | 1.49% | $216.2 million | 0.01% | +308,150 | 13F |
| Artisan Partners Limited Partnership | 2,640,024 | 1.47% | $209.3 million | 0.34% | +581,716 | 13F |
| Tweedy, Browne Co LLC | 2,280,311 | 1.27% | $180.8 million | 13.70% | +4,686 | 13F |
| Deep Track Capital, LP | 2,200,000 | 1.22% | $174.4 million | 2.57% | +250,000 | 13F |
| Goldman Sachs Group Inc. | 2,109,945 | 1.17% | $167.3 million | 0.02% | +410,098 | 13F |
| Baker Bros. Advisors LP | 2,047,727 | 1.14% | $162.4 million | 0.82% | no change | 13F |
| Deerfield Management Company, L.P. | 1,979,669 | 1.10% | $157.0 million | 1.95% | no change | 13F |
| American Century Companies Inc. | 1,947,076 | 1.08% | $154.4 million | 0.07% | +283,273 | 13F |
| Franklin Resources Inc. | 1,623,377 | 0.90% | $128.7 million | 0.03% | +48,354 | 13F |
| Charles Schwab Investment Management Inc. | 1,605,054 | 0.89% | $127.3 million | 0.02% | +21,788 | 13F |
| Barclays PLC | 1,603,136 | 0.89% | $127.1 million | 0.04% | +1,313,262 | 13F |
| Pictet Asset Management Holding SA | 1,596,998 | 0.89% | $127.0 million | 0.12% | +162,003 | 13F |
| UBS AM, a distinct business unit of UBS Asset Management Americas LLC | 1,454,672 | 0.81% | $115.3 million | 0.02% | -20,960 | 13F |
| Polar Capital Holdings Plc | 1,454,021 | 0.81% | $115.3 million | 0.33% | +624,510 | 13F |
| Alyeska Investment Group, L.P. | 1,417,916 | 0.79% | $112.4 million | 0.29% | +944,766 | 13F |
| Nomura Asset Management International Inc. | 1,300,392 | 0.72% | $103.1 million | 0.16% | +515,111 | 13F |
| Morgan Stanley | 1,281,444 | 0.71% | $101.6 million | 0.01% | +254,935 | 13F |
| Invesco Ltd. | 1,120,707 | 0.62% | $88.9 million | 0.01% | -156,651 | 13F |
| Vanguard Fiduciary Trust Co. | 1,060,845 | 0.59% | $84.1 million | 0.02% | +36,468 | 13F |
| Bellevue Group AG | 972,258 | 0.54% | $77.1 million | 1.62% | -846,407 | 13F |
| Groupama Asset Managment | 937,083 | 0.52% | $75.2 million | 0.96% | +112,543 | 13F |
| Northern Trust Corp. | 913,610 | 0.51% | $72.4 million | 0.01% | +45,431 | 13F |
| Capital International Investors | 823,764 | 0.46% | $65.3 million | 0.01% | new | 13F |
| Davern Capital Partners, LP | 798,709 | 0.44% | $63.3 million | 10.80% | +411,806 | 13F |
| Bank of America Corp. | 790,990 | 0.44% | $62.7 million | 0.00% | -49,608 | 13F |
| Summit Partners Public Asset Management, LLC | 787,263 | 0.44% | $62.4 million | 1.62% | -616,770 | 13F |
| GW&K Investment Management, LLC | 746,966 | 0.42% | $59.2 million | 0.46% | -32,383 | 13F |
| BNP Paribas Asset Management Holding S.A. | 734,219 | 0.41% | $58.2 million | 0.06% | -173,314 | 13F |
| Nuveen, LLC | 726,282 | 0.40% | $57.6 million | 0.01% | +77,786 | 13F |
| Connor, Clark & Lunn Investment Management Ltd. | 684,236 | 0.38% | $54.3 million | 0.10% | -189,853 | 13F |
| Eversept Partners, LP | 664,684 | 0.37% | $52.7 million | 2.87% | +32,584 | 13F |
| Voloridge Investment Management, LLC | 655,454 | 0.36% | $52.0 million | 0.22% | -17,404 | 13F |
| Massachusetts Financial Services Co. | 651,816 | 0.36% | $51.7 million | 0.02% | -14,300 | 13F |
| Neuberger Berman Group LLC | 633,533 | 0.35% | $50.2 million | 0.03% | +190,261 | 13F |
| Arrowstreet Capital, Limited Partnership | 632,028 | 0.35% | $50.1 million | 0.02% | -105,831 | 13F |
| UBS Group AG | 624,874 | 0.35% | $49.5 million | 0.01% | -183,569 | 13F |
| TimesSquare Capital Management, LLC | 614,070 | 0.34% | $48.7 million | 0.72% | +338,396 | 13F |
| Eventide Asset Management, LLC | 575,000 | 0.32% | $45.6 million | 0.61% | no change | 13F |
The 50 largest of the 516 funds that reported a position in IONS in their 13F for the quarter ended 30 June 2026, by the value each reported.
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Share of all is the fund's part of all the shares the funds reported. Change is shares against the fund's 13F for the quarter before. A 13F lists a manager's long positions in US-listed shares at the quarter's end. What is a 13F?Options the funds reported on IONS
| Fund | Option | Shares under the options | Value of those shares | Quarter ended | Filing |
|---|---|---|---|---|---|
| Citadel Advisors | Puts | 386,500 | $30.6 million | 30 June 2026 | 13F |
| Millennium Management | Calls | 257,500 | $20.4 million | 30 June 2026 | 13F |
| Citadel Advisors | Calls | 232,500 | $18.4 million | 30 June 2026 | 13F |
| Point72 Asset Management | Calls | 20,300 | $1.6 million | 30 June 2026 | 13F |
| Point72 Asset Management | Puts | 13,900 | $1.1 million | 30 June 2026 | 13F |
A 13F lists calls and puts by the shares they cover and what those shares were worth at the quarter's end, not what the options cost.
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They are not counted in the holdings above. A put gains when the stock falls, a call when it rises, and a fund may hold either to hedge.Schedule 13D and 13G filed on the name, last twelve months
| Filed | Schedule | Who | Holding | Of the class | Event date | Rule or purpose | Filing |
|---|---|---|---|---|---|---|---|
| 15 May 2026 | 13G/A | T. Rowe Price Investment Management, Inc. and 1 other | 6.2 million | 3.7% | 31 March 2026 | passive, institutional (13d-1(b)) | EDGAR |
| 14 May 2026 | 13G/A | Capital World Investors and 1 other | 21.2 million | 12.8% | 31 March 2026 | passive, institutional (13d-1(b)) | EDGAR |
| 30 April 2026 | 13G | Vanguard Capital Management and 1 other | 8.3 million | 5.0% | 31 March 2026 | passive, institutional (13d-1(b)) | EDGAR |
| 27 March 2026 | 13G/A | The Vanguard Group and 1 other | 0 | 0.0% | 13 March 2026 | passive, institutional (13d-1(b)) | EDGAR |
| 17 February 2026 | 13G/A | T. Rowe Price Investment Management, Inc. and 1 other | 9.1 million | 5.6% | 31 December 2025 | passive, institutional (13d-1(b)) | EDGAR |
| 7 January 2026 | 13G/A | Capital World Investors and 1 other | 18.0 million | 11.1% | 31 December 2025 | passive, institutional (13d-1(b)) | EDGAR |
| 14 November 2025 | 13G/A | T. Rowe Price Investment Management, Inc. and 1 other | 13.2 million | 8.3% | 30 September 2025 | passive, institutional (13d-1(b)) | EDGAR |
A Schedule 13D is filed by anyone who crosses 5% of a class with intent to influence; a 13G by a passive holder.
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Amendments (/A) report a change, including an exit to zero. Holding and percentage are as the filer stated them on the cover page; the purpose is the filer's own words, cut short. 13D and 13GFails to deliver
| Settlement date | Shares failed | Price | File |
|---|---|---|---|
| 10 September 2026 | 5,975 | $56.02 | SEC |
| 9 September 2026 | 8,518 | $56.71 | SEC |
| 8 September 2026 | 20 | $58.09 | SEC |
| 4 September 2026 | 14 | $58.13 | SEC |
| 19 August 2026 | 3,049 | $59.62 | SEC |
| 18 August 2026 | 15 | $58.63 | SEC |
| 17 August 2026 | 522 | $57.24 | SEC |
Shares that failed to deliver at settlement, per day, from the SEC's half-month files, which arrive about two weeks after the period.