Septerna, Inc. 13F holders
153 funds reported a position in Septerna, Inc. in their 13F for the quarter ended 30 June 2026, together 47.4 million shares worth $1.59 billion. Against the quarter before, 44 opened a position, 49 added, 32 trimmed and 16 sold out; together they bought a net 1.1 million shares. The largest holders: Ra Capital Management, L.P., TRV GP V, LLC and Driehaus Capital Management LLC.
Funds holding153+29 on Q1 2026
Shares they held47.4Mworth $1.59 billion
Net bought on the quarter1.1M sharesabout $37.0 million at the funds' values
Funds buying to selling93 to 48opened or added, to cut or sold
Opened 44Added 49Held 26Trimmed 32Sold out 16
What each fund did in SEPN against its 13F for the quarter before; a change under 0.1% of a holding counts as held
Funds reporting a position in SEPN in their 13F, each quarter; hover a bar for the shares they held
Filed so far for the quarter to 30 September 2026
2,671 funds have filed their 13F for the quarter so far; the rest are due by 16 November 2026. Of those, 14 reported a position in Septerna, Inc.: 2 opened one, 5 added, 1 trimmed and 0 sold out, a net 34 shares bought.
| Fund | Change in shares | Shares now | Status | Filing |
|---|---|---|---|---|
| Signaturefd, LLC | -825 | 141 | trimmed | 13F |
| Sterling Capital Management LLC | +430 | 630 | added | 13F |
| Gamma Investing LLC | +259 | 1,378 | added | 13F |
| GF Fund Management Co. Ltd | +83 | 1,033 | added | 13F |
| Nisa Investment Advisors, LLC | +61 | 829 | added | 13F |
| Financial Consulate, Inc. | +22 | 22 | new | 13F |
| SJS Investment Consulting Inc. | +2 | 8 | added | 13F |
| Farther Finance Advisors, LLC | +2 | 2 | new | 13F |
The largest moves in the name among the funds that have filed, against each fund's previous 13F.
The well-known funds
Of the 44 funds followed here, 7 reported a position in Septerna, Inc. in a 13F for the quarter ended 30 June 2026. The largest: Geode Capital Management, 679,163 shares worth $22.8 million, 0.0% of its reported book. New this quarter: Citadel Advisors. In the quarter, 4 funds added or opened a position and 2 trimmed or sold out; together they bought a net 115,859 shares, about $3.9 million at the funds' own value per share on 30 June 2026. A change under 0.1% of a holding counts as held.
| Fund | Shares | Value | Of its book | Change on the quarter | Status | Quarter ended | Filing |
|---|---|---|---|---|---|---|---|
| Geode Capital Management | 679,163 | $22.8 million | 0.0% | +34,017 | added | 30 June 2026 | 13F |
| Two Sigma Investments | 220,885 | $7.4 million | 0.0% | +145,518 | added | 30 June 2026 | 13F |
| Millennium Management | 50,562 | $1.7 million | 0.0% | -73,539 | trimmed | 30 June 2026 | 13F |
| Renaissance Technologies | 41,419 | $1.4 million | 0.0% | +3,719 | added | 30 June 2026 | 13F |
| Alyeska | 35,000 | $1.2 million | 0.0% | no change | held | 30 June 2026 | 13F |
| FMR LLC | 23,240 | $778,308 | 0.0% | -206 | trimmed | 30 June 2026 | 13F |
| Citadel Advisors | 6,350 | $212,662 | 0.0% | +6,350 | new | 30 June 2026 | 13F |
Value is what the fund reported.
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Change is shares against the fund's previous 13F; a fund with one filing read shows no change. 13Fs cover long US positions of managers above $100 million and are filed up to 45 days after the quarter.The largest holders
| Fund | Shares | Share of all | Value | Of its book | Change in shares | Filing |
|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6,995,858 | 14.75% | $234.3 million | 2.04% | no change | 13F |
| TRV GP V, LLC | 6,215,591 | 13.10% | $208.2 million | 41.78% | no change | 13F |
| Driehaus Capital Management LLC | 4,433,058 | 9.34% | $148.5 million | 0.86% | +37,486 | 13F |
| TRV GP Vi, LLC | 4,211,659 | 8.88% | $141.0 million | 60.73% | no change | 13F |
| Samsara Biocapital, LLC | 3,149,128 | 6.64% | $105.5 million | 8.66% | no change | 13F |
| Goldman Sachs Group Inc. | 3,062,766 | 6.46% | $102.6 million | 0.01% | +156,339 | 13F |
| BlackRock, Inc. | 1,932,088 | 4.07% | $64.7 million | 0.00% | +109,914 | 13F |
| Siren, L.L.C. | 1,900,000 | 4.01% | $63.6 million | 1.29% | -100,000 | 13F |
| Avoro Capital Advisors LLC | 1,337,500 | 2.82% | $44.8 million | 0.40% | no change | 13F |
| Jupiter Topco LLC | 1,307,500 | 2.76% | $43.7 million | 0.02% | first 13F | 13F |
| Vanguard Capital Management LLC | 1,221,673 | 2.58% | $40.9 million | 0.00% | +24,711 | 13F |
| Primecap Management Co. | 1,167,382 | 2.46% | $39.1 million | 0.02% | +118,548 | 13F |
| First Light Asset Management, LLC | 963,260 | 2.03% | $32.3 million | 1.96% | +230,400 | 13F |
| ADAR1 Capital Management, LLC | 940,747 | 1.98% | $31.5 million | 1.49% | -149,071 | 13F |
| Geode Capital Management, LLC | 679,163 | 1.43% | $22.8 million | 0.00% | +34,017 | 13F |
| State Street Corp. | 652,630 | 1.38% | $21.9 million | 0.00% | +21,183 | 13F |
| Loomis Sayles & Co. L P | 624,752 | 1.32% | $20.9 million | 0.03% | new | 13F |
| Casdin Capital, LLC | 553,268 | 1.17% | $18.5 million | 0.93% | no change | 13F |
| Catalio Capital Management, LP | 536,152 | 1.13% | $18.0 million | 3.37% | +241,792 | 13F |
| Algert Global LLC | 397,487 | 0.84% | $13.3 million | 0.16% | +376,452 | 13F |
| Kalehua Capital Management LLC | 389,088 | 0.82% | $13.0 million | 4.16% | no change | 13F |
| Balyasny Asset Management L.P. | 350,442 | 0.74% | $11.7 million | 0.02% | +113,763 | 13F |
| Longaeva Partners L.P. | 298,171 | 0.63% | $10.0 million | 0.29% | +223,604 | 13F |
| Soleus Capital Management, L.P. | 275,000 | 0.58% | $9.2 million | 0.32% | no change | 13F |
| Vanguard Portfolio Management LLC | 230,184 | 0.49% | $7.7 million | 0.00% | +35,141 | 13F |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | 0.47% | $7.5 million | 0.01% | -1,293 | 13F |
| Two Sigma Investments, LP | 220,885 | 0.47% | $7.4 million | 0.01% | +145,518 | 13F |
| Northern Trust Corp. | 201,131 | 0.42% | $6.7 million | 0.00% | +36,601 | 13F |
| Charles Schwab Investment Management Inc. | 187,041 | 0.39% | $6.3 million | 0.00% | +5,461 | 13F |
| Woodline Partners LP | 185,535 | 0.39% | $6.2 million | 0.02% | new | 13F |
| Vanguard Fiduciary Trust Co. | 165,656 | 0.35% | $5.5 million | 0.00% | +11,172 | 13F |
| Morgan Stanley | 134,377 | 0.28% | $4.5 million | 0.00% | +23,847 | 13F |
| UBS Group AG | 89,874 | 0.19% | $3.0 million | 0.00% | -27,105 | 13F |
| JPMorgan Chase & Co. | 85,301 | 0.18% | $3.0 million | 0.00% | +627 | 13F |
| Federated Hermes, Inc. | 86,753 | 0.18% | $2.9 million | 0.00% | -2,548 | 13F |
| Lazard Asset Management LLC | 75,425 | 0.16% | $2.5 million | 0.00% | new | 13F |
| Dimensional Fund Advisors LP | 75,309 | 0.16% | $2.5 million | 0.00% | new | 13F |
| Arrowstreet Capital, Limited Partnership | 74,649 | 0.16% | $2.5 million | 0.00% | new | 13F |
| Jacobs Levy Equity Management, Inc. | 68,180 | 0.14% | $2.3 million | 0.01% | +39,744 | 13F |
| Hussman Strategic Advisors, Inc. | 63,000 | 0.13% | $2.1 million | 0.49% | -42,000 | 13F |
| American Century Companies Inc. | 60,973 | 0.13% | $2.0 million | 0.00% | -317 | 13F |
| Bank of New York Mellon Corp | 56,176 | 0.12% | $1.9 million | 0.00% | -2,533 | 13F |
| XTX Topco Ltd | 54,489 | 0.11% | $1.8 million | 0.02% | +17,766 | 13F |
| Millennium Management LLC | 50,562 | 0.11% | $1.7 million | 0.00% | -73,539 | 13F |
| Barclays PLC | 49,821 | 0.11% | $1.7 million | 0.00% | +27,107 | 13F |
| Elmind Capital, LP | 49,444 | 0.10% | $1.7 million | 0.42% | new | 13F |
| Nuveen, LLC | 48,229 | 0.10% | $1.6 million | 0.00% | +19,053 | 13F |
| Sofinnova Investments, Inc. | 47,506 | 0.10% | $1.6 million | 0.09% | no change | 13F |
| D. E. Shaw & Co., Inc. | 46,483 | 0.10% | $1.6 million | 0.00% | new | 13F |
| Jane Street Group, LLC | 45,552 | 0.10% | $1.5 million | 0.00% | new | 13F |
The 50 largest of the 153 funds that reported a position in SEPN in their 13F for the quarter ended 30 June 2026, by the value each reported.
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Share of all is the fund's part of all the shares the funds reported. Change is shares against the fund's 13F for the quarter before. A 13F lists a manager's long positions in US-listed shares at the quarter's end. What is a 13F?Options the funds reported on SEPN
| Fund | Option | Shares under the options | Value of those shares | Quarter ended | Filing |
|---|---|---|---|---|---|
| Citadel Advisors | Calls | 81,800 | $2.7 million | 30 June 2026 | 13F |
A 13F lists calls and puts by the shares they cover and what those shares were worth at the quarter's end, not what the options cost.
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They are not counted in the holdings above. A put gains when the stock falls, a call when it rises, and a fund may hold either to hedge.Schedule 13D and 13G filed on the name, last twelve months
| Filed | Schedule | Who | Holding | Of the class | Event date | Rule or purpose | Filing |
|---|---|---|---|---|---|---|---|
| 14 August 2026 | 13D/A | RA Capital Management, L.P. and 3 others | 5.5 million | 11.8% | 12 August 2026 | EDGAR | |
| 14 August 2026 | 13G/A | Driehaus Capital Management LLC and 1 other | 4.4 million | 9.8% | 30 June 2026 | passive, institutional (13d-1(b)) | EDGAR |
| 17 February 2026 | 13G/A | Biotechnology Value Fund L P and 19 others | 1.7 million | 3.8% | 31 December 2025 | passive, under 20% (13d-1(c)) | EDGAR |
A Schedule 13D is filed by anyone who crosses 5% of a class with intent to influence; a 13G by a passive holder.
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Amendments (/A) report a change, including an exit to zero. Holding and percentage are as the filer stated them on the cover page; the purpose is the filer's own words, cut short. 13D and 13GFails to deliver
| Settlement date | Shares failed | Price | File |
|---|---|---|---|
| 27 August 2026 | 28 | $40.25 | SEC |
Shares that failed to deliver at settlement, per day, from the SEC's half-month files, which arrive about two weeks after the period.