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Tempus AI, Inc.: Q1 FY2026 earnings call

What management said about Q1 FY2026, from the documents filed with the SEC on 5 May 2026: press release. Guidance figures: 1 raised, 1 kept. The quarter’s numbers.

Key takeaways

  • Revenue rose 36% year-over-year: Total revenue was $348.1 million, up 36.1% from $255.7 million in the first quarter of 2025. Diagnostics and Data and Applications both contributed to the increase. Source
  • Adjusted EBITDA loss narrowed: Adjusted EBITDA was a loss of $2.8 million, against a $16.2 million loss in the first quarter of 2025 and $12.9 million positive in the fourth quarter of 2025. Source
  • Diagnostics revenue rose 34.7%: Diagnostics revenue was $261.1 million, up from $193.8 million in the first quarter of 2025. Source
  • Data and Applications rose 40.5%: Data and Applications revenue was $87.0 million, up from $61.9 million. Insights, covering data licensing and modeling, grew 44.1%. Source
  • Gross margin rose to 63.8%: Gross margin was 63.8%, against 60.7% a year earlier. Non-GAAP gross margin was 65.0%, against 61.4%. Source
  • Net loss included stock compensation: Net loss was $125.9 million, against $68.0 million a year earlier. It included $56.3 million of stock compensation and related payroll taxes and a $32.3 million unrealized loss on marketable securities. Source
  • Cash and securities $643.8M: Cash and marketable securities totaled $643.8 million at March 31, 2026, against $759.7 million at December 31, 2025. Source

“underscores the accelerating demand for our AI-driven diagnostic platform and the immense value of our multimodal data and corresponding AI models”

Eric Lefkofsky, Founder and CEO of Tempus

Guidance

AreaPeriodFigureAgainst last quarter
Revenue SourceFull year 2026$1.59 billion to $1.60 billionRaised from $1.59 billion
Adjusted EBITDA SourceFull year 2026~$65 millionKept

What changed from last quarter

  • Guidance raised: Full-year 2026 revenue guidance raised to $1.59 billion to $1.60 billion, from $1.59 billion. Source
  • Guidance kept: Full-year 2026 Adjusted EBITDA expectation of about $65 million carried over from the prior quarter. Source
  • New: New multi-year strategic collaboration with Merck on biomarker discovery and development, using multimodal data and the Lens platform. Source
  • New: Expanded collaboration with Gilead, providing enterprise-wide access to the Lens platform and multimodal datasets. Source
  • New: New strategic collaboration with Blood Cancer United to build a pediatric acute myeloid leukemia real-world data registry. Source

Results and growth drivers

  • Revenue rose 36% year-over-year: Total revenue was $348.1 million, up 36.1% from $255.7 million in the first quarter of 2025. Diagnostics and Data and Applications both contributed to the increase. Source
  • Gross profit rose 43%: Gross profit was $222.0 million, up from $155.2 million, with growth led by Data and Applications. Source
  • Adjusted EBITDA loss narrowed: Adjusted EBITDA was a loss of $2.8 million, against a $16.2 million loss in the first quarter of 2025 and $12.9 million positive in the fourth quarter of 2025. Source

Diagnostics and Data and Applications

  • Diagnostics revenue rose 34.7%: Diagnostics revenue was $261.1 million, up from $193.8 million in the first quarter of 2025. Source
  • Oncology and Hereditary volumes grew: Oncology volume grew 28% and Hereditary volume grew 54%. Excluding Ambry's 2025 pre-acquisition volumes, Hereditary growth was 7%, given the February closing. Source
  • Data and Applications rose 40.5%: Data and Applications revenue was $87.0 million, up from $61.9 million. Insights, covering data licensing and modeling, grew 44.1%. Source

“as we deploy more sophisticated algorithms across our platform, driving 36% revenue growth year-over-year, with particular strength in our Oncology diagnostic business and data and modeling business”

Eric Lefkofsky, Founder and CEO of Tempus

Products and customers

  • MRD volume rose about 500%: MRD testing volume was about 6,500 tests in the quarter, up about 500% year over year. Source
  • RNA-based HRD algorithm launched: A pan-cancer algorithm using RNA expression data identifies Homologous Recombination Deficiency, which may widen PARP inhibitor eligibility beyond DNA testing. Source
  • ALERT study linked EHR alerts to procedures: The ALERT trial with Medtronic reported a 40% increase in heart valve procedures for patients with significant disease, from AI-driven EHR notifications. Source
  • Study found actionable findings beyond standard tests: A JCO Precision Oncology study reported that tumor-normal matching and RNA sequencing identified actionable findings in 12% of patients that standard testing did not identify. Source
  • Related party revenue rose to $21.8M: Revenue from related parties was $21.8 million, against $0.6 million in the first quarter of 2025. Related party receivables were $15.7 million at quarter end. Source

Costs and margins

  • Gross margin rose to 63.8%: Gross margin was 63.8%, against 60.7% a year earlier. Non-GAAP gross margin was 65.0%, against 61.4%. Source
  • Segment margins moved in opposite directions: Diagnostics gross margin was 61.3%, against 56.3%. Data and applications gross margin was 71.1%, against 74.6%. Source
  • Operating expenses rose with SG&A: Selling, general and administrative expense was $212.6 million, up from $154.6 million. It includes $16.9 million of amortization of acquired intangibles. Source
  • Non-GAAP operating loss narrowed: Non-GAAP loss from operations was $11.6 million, against $25.8 million a year earlier, a 55.1% decrease. Source
  • Net loss included stock compensation: Net loss was $125.9 million, against $68.0 million a year earlier. It included $56.3 million of stock compensation and related payroll taxes and a $32.3 million unrealized loss on marketable securities. Source

Cash, debt and capital spending

  • Cash and securities $643.8M: Cash and marketable securities totaled $643.8 million at March 31, 2026, against $759.7 million at December 31, 2025. Source
  • Operating cash outflow narrowed: Net cash used in operating activities was $73.3 million, against $105.6 million a year earlier. Accounts payable fell $50.6 million in the cash flow statement. Source
  • Capital spending rose: Purchases of property and equipment were $8.2 million, against $2.1 million. Capitalized software costs were $1.9 million, against $1.3 million. Source
  • Debt balances at quarter end: Long-term debt, net was $204.6 million and the revolving credit facility was $100.0 million at March 31, 2026. Source

Strategy and partnerships

  • Merck biomarker collaboration signed: A multi-year collaboration with Merck aims to accelerate biomarker discovery and development using multimodal data and the Lens analytical platform. Source
  • Gilead enterprise access expanded: The expanded Gilead collaboration gives enterprise-wide access to the Lens platform and multimodal datasets, aimed at its oncology pipeline through real-world evidence and AI-driven insights. Source
  • Pediatric AML registry partnership: The collaboration with Blood Cancer United aims to build one of the largest real-world data registries for pediatric acute myeloid leukemia. Source

Below-the-line items

  • Interest expense fell to $14.3M: Interest expense was $14.3 million, against $18.0 million. Interest income was $3.9 million, against $1.8 million. Source
  • Other expense held near prior level: Other expense, net was $27.7 million, against $27.5 million. Loss before income taxes was $122.9 million, against $112.3 million. Source
  • Tax benefit fell to $62 thousand: Benefit from income taxes was $62 thousand, against $46.2 million. Losses from equity method investments were $3.1 million, against $1.9 million. Source

Per-share results

  • Basic loss per share $0.70: Net loss per share was $0.70 basic and $0.71 diluted, against $0.40 for both in the first quarter of 2025. Source
  • Non-GAAP loss per share $0.13: Non-GAAP net loss was $22.6 million, or $0.13 per share basic, against $41.6 million or $0.24 a year earlier. Source
  • Weighted share count rose: Weighted-average basic shares were 178.9 million, against 170.5 million. Diluted weighted-average shares were 178.96 million. Source

Coming up, as management said on 5 May 2026

  • Investor Day on May 29: Investor Day on Friday, May 29, 2026, features senior leaders presenting on Diagnostics and Data and Applications. The webcast starts at 8:00 a.m. Central Time. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.