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PFM Health Sciences, LP

CIK 1442756 · latest 13F filed 14 August 2026 · Read the filing on EDGAR

PFM Health Sciences, LP reported 96 US-listed holdings worth $1.15 billion in its 13F for the quarter ended 30 June 2026, filed 14 August 2026. Its largest: Ascendis Pharma A/s (5.4%), Axsome Therapeutics Inc. (4.7%) and Eli Lilly & Co. (4.1%). Against the quarter before, it opened 33 positions, added to 22, trimmed 41 and sold out of 13.

Reported holdings$1.15B+23.4% on Q1 2026
Positions96+20 on Q1 2026
The largest ten34.3%of its reported holdings
Latest 13FQ2 2026filed 14 August 2026
Where the money is
OpenedAdded toTrimmed
ASND5.4%AXSM4.7%LLY4.1%JAZZ3.4%HUM3.3%UNH3.2%NBIX3.1%INBX2.5%UTHR2.4%RVMD2.3%ICLR2.1%THC2.1%EW2.0%82 more57.7%

The 14 largest of its 96 positions, each sized by its share of the reported holdings, coloured by the change in shares against Q1 2026.

Reported holdings, quarter by quarter
Q3 2024: $1.71 billion in 72 positions$1.71BQ3 24Q4 2024: $1.28 billion in 71 positions$1.28BQ4 24Q1 2025: $1.27 billion in 62 positions$1.27BQ1 25Q2 2025: $1.13 billion in 55 positions$1.13BQ2 25Q3 2025: $1.16 billion in 66 positions$1.16BQ3 25Q4 2025: $972.6 million in 76 positions$973MQ4 25Q1 2026: $933.3 million in 76 positions$933MQ1 26Q2 2026: $1.15 billion in 96 positions$1.15BQ2 26

What the fund reported holding at each quarter's end; hover a bar for the number of positions

What it did on the quarter

Opened 33Added 22Trimmed 41Sold out 13
Opened: 33Added: 22Trimmed: 41Sold out: 13

Its positions against its 13F for the quarter to 31 March 2026; a change under 0.1% of a position counts as held

Opened 33

  1. Ascendis Pharma A/s ASND$62.2 million
  2. Humana Inc. HUM$37.5 million
  3. Mettler Toledo International Inc. MTD$17.0 million
  4. Merck & Co., Inc. MRK$16.3 million
  5. Cytokinetics Inc. CYTK$16.3 million
  6. Lantheus Holdings, Inc. LNTH$16.2 million
  7. CVS Health Corp. CVS$14.2 million
  8. Gilead Sciences, Inc. GILD$11.5 million

and 25 more in the table below

Added to 22

  1. ICON plc ICLR+78,982 shares · +137%
  2. UnitedHealth Group Inc. UNH+30,238 shares · +52%
  3. Stryker Corp. SYK+34,680 shares · +158%
  4. Waters Corp. WAT+20,062 shares · +50%
  5. Thermo Fisher Scientific Inc. TMO+13,664 shares · +92%
  6. United Therapeutics Corp. UTHR+10,186 shares · +26%
  7. Arrowhead Pharmaceuticals, Inc. ARWR+67,388 shares · +105%
  8. Eupraxia Pharmaceuticals Inc. EPRX+669,790 shares · +124%

and 14 more in the table below

Trimmed 41

  1. Tenet Healthcare Corp. THC-271,995 shares · -68%
  2. Eli Lilly & Co. LLY-26,504 shares · -40%
  3. Penumbra Inc. PEN-79,558 shares · -57%
  4. Compass Pathways PLC CMPS-1.1 million shares · -82%
  5. Axsome Therapeutics Inc. AXSM-44,708 shares · -17%
  6. Natera Inc Com NTRA-37,927 shares · -63%
  7. Amneal Pharmaceuticals Inc. AMRX-449,381 shares · -48%
  8. Indivior Pharmaceuticals, Inc. INDV-173,458 shares · -30%

and 33 more in the table below

Sold out of 13

  1. Ascendis Pharma A/s ASND$34.8 million last quarter
  2. Glaukos Corp. GKOS$23.2 million last quarter
  3. Centessa Pharmaceuticals PLC CNTA$21.0 million last quarter
  4. Neogenomics Inc. NEO$13.2 million last quarter
  5. Dexcom Inc. DXCM$9.4 million last quarter
  6. Terns Pharmaceuticals Inc. TERN$9.1 million last quarter
  7. Soleno Therapeutics Inc. SLNO$8.3 million last quarter
  8. Billiontoone Inc. BLLN$7.0 million last quarter

What it holds

CompanySharesValueOf its bookChange in shares
Ascendis Pharma A/s ASND233,171$62.2 million5.40%new
Axsome Therapeutics Inc. AXSM219,596$53.8 million4.67%-44,708
Eli Lilly & Co. LLY39,258$47.1 million4.09%-26,504
Jazz Pharmaceuticals plc JAZZ160,768$38.7 million3.36%-17,376
Humana Inc. HUM94,375$37.5 million3.25%new
UnitedHealth Group Inc. UNH88,276$36.7 million3.19%+30,238
Neurocrine Biosciences Inc. NBIX213,407$36.0 million3.12%-2,271
Inhibrx Biosciences Inc. INBX308,385$29.2 million2.54%+2,954
United Therapeutics Corp. UTHR49,991$27.1 million2.35%+10,186
Revolution Medicines, Inc. RVMD143,222$26.8 million2.33%+2,452
ICON plc ICLR136,482$23.7 million2.06%+78,982
Tenet Healthcare Corp. THC126,572$23.7 million2.06%-271,995
Edwards Lifesciences Corp. EW250,453$22.7 million1.97%-4,057
Waters Corp. WAT59,825$22.4 million1.95%+20,062
Penumbra Inc. PEN60,221$19.0 million1.65%-79,558
Bridgebio Pharma Inc. BBIO253,358$18.9 million1.64%-4,389
Stryker Corp. SYK56,637$17.8 million1.55%+34,680
Mettler Toledo International Inc. MTD13,344$17.0 million1.48%new
Indivior Pharmaceuticals, Inc. INDV401,208$16.5 million1.43%-173,458
Merck & Co., Inc. MRK127,118$16.3 million1.42%new
Cytokinetics Inc. CYTK191,686$16.3 million1.42%new
Lantheus Holdings, Inc. LNTH146,403$16.2 million1.41%new
Centene Corp. CNC248,867$16.0 million1.39%-14,619
Cooper Companies, Inc. COO220,890$15.8 million1.38%+51,061
Madrigal Pharmaceuticals Inc. MDGL29,313$15.7 million1.37%-4,833
Acadia Healthcare Company, Inc. ACHC524,934$15.5 million1.35%-57,811
Oruka Therapeutics Inc. ORKA158,825$15.1 million1.31%-15,227
Oscar Health Inc. Class A OSCR519,016$14.8 million1.29%+19,179
Thermo Fisher Scientific Inc. TMO28,496$14.3 million1.24%+13,664
CVS Health Corp. CVS137,457$14.2 million1.23%new
Merit Medical Systems Inc. MMSI197,038$13.7 million1.19%+34,569
Praxis Precision Medicines I PRAX38,575$12.9 million1.12%+3,137
Celldex Therapeutics Inc. CLDX342,751$12.8 million1.11%+17,794
Novo Nordisk A/S NVO265,016$12.7 million1.10%+67,835
Integer Holdings Corp. ITGR126,669$11.8 million1.03%-8,412
Dianthus Therapeutics Inc. DNTH121,222$11.8 million1.03%-50,915
Definium Therapeutics Inc. DFTX249,020$11.7 million1.02%+43,703
Gilead Sciences, Inc. GILD90,858$11.5 million1.00%new
Rhythm Pharmaceuticals Inc. RYTM101,550$11.3 million0.98%-35,071
Henry Schein Inc. HSIC134,423$11.2 million0.97%-18,691
Arrowhead Pharmaceuticals, Inc. ARWR131,667$10.7 million0.93%+67,388
Tango Therapeutics Inc. TNGX326,047$10.2 million0.88%-80,198
Teleflex Inc. TFX79,708$10.1 million0.88%new
Viking Therapeutics Inc. VKTX255,330$10.0 million0.86%-7,776
BrightSpring Health Services, Inc. BTSG141,914$9.9 million0.86%-45,421
Vera Therapeutics Inc. VERA224,289$9.6 million0.84%+49,422
Roivant Sciences Ltd. ROIV268,008$9.5 million0.82%+60,562
CG Oncology Inc. CGON128,286$9.1 million0.79%-37,639
Amneal Pharmaceuticals Inc. AMRX480,715$8.3 million0.72%-449,381
Eupraxia Pharmaceuticals Inc. EPRX1,210,661$8.0 million0.69%+669,790
Irhythm Technologies Inc. IRTC65,196$7.8 million0.67%new
Kodiak Sciences Inc. KOD193,315$7.5 million0.65%+78,596
Abbott Laboratories ABT82,230$7.5 million0.65%-58,202
West Pharmaceutical Services Inc. WST20,733$7.4 million0.65%new
Takeda Pharmaceutical Company Limited TAK444,173$7.1 million0.62%new
Hinge Health Inc. HNGE82,860$6.9 million0.60%new
Arcutis Biotherapeutics Inc. ARQT242,069$6.3 million0.55%new
Integra LifeSciences Holdings Corp. IART348,746$6.3 million0.54%new
Illumina, Inc. ILMN35,040$6.2 million0.53%+6,171
Meiragtx Holdings PLC MGTX455,286$6.2 million0.53%new
Oculis Holding AG OCS436,042$6.0 million0.53%new
Natera Inc Com NTRA22,077$6.0 million0.52%-37,927
Abivax SA ABVX43,264$5.8 million0.50%+16,600
Guardant Health Inc. GH36,701$5.5 million0.48%new
Celcuity Inc. CELC52,155$5.5 million0.47%new
Belite Bio Inc. BLTE34,803$5.4 million0.47%-24,629
Structure Therapeutics Inc. GPCR91,550$4.9 million0.43%-34,833
Arcus Biosciences, Inc. RCUS152,129$4.7 million0.41%new
Charles River Laboratories International, Inc. CRL18,747$4.3 million0.37%new
Elanco Animal Health Inc. ELAN172,489$4.2 million0.37%new
argenx SE ARGX4,482$4.2 million0.36%-53
Bio-Rad Laboratories, Inc. BIO13,995$4.1 million0.36%new
Spyre Therapeutics Inc. SYRE46,217$4.1 million0.36%new
MBX Biosciences Inc. MBX70,971$3.9 million0.34%-923
Mirum Pharmaceuticals Inc. MIRM31,536$3.7 million0.32%new
Cullinan Therapeutics Inc. CGEM192,442$3.5 million0.30%-34,964
Compass Pathways PLC CMPS247,589$3.5 million0.30%-1,119,510
HCA Healthcare, Inc. HCA8,295$3.2 million0.28%-5,056
Capricor Therapeutics Inc. CAPR122,221$2.9 million0.26%-1,610
Denali Therapeutics Inc. DNLI100,966$2.6 million0.23%new
Syndax Pharmaceuticals Inc. SNDX118,422$2.6 million0.22%-126,599
Amylyx Pharmaceuticals Inc. AMLX143,700$2.6 million0.22%-1,575
Tarsus Pharmaceuticals Inc. TARS40,579$2.6 million0.22%-39,647
Outset Med Inc. OM582,122$2.5 million0.22%-12,508
Omada Health Inc. OMDA114,442$2.5 million0.22%new
Erasca Inc. ERAS134,088$2.5 million0.21%new
Cencora, Inc. COR7,385$2.1 million0.18%new
Biocryst Pharmaceuticals Inc. BCRX207,357$2.1 million0.18%new
Omnicell, Inc. OMCL49,040$2.0 million0.18%new
Cvrx Inc. CVRX369,572$1.9 million0.16%new
Hims & Hers Health, Inc. HIMS49,454$1.7 million0.15%new
Mineralys Therapeutics Inc. MLYS62,418$1.7 million0.15%-80,259
Tectonic Therapeutic Inc. TECX45,631$1.6 million0.14%-498
Uniqure NV QURE26,396$1.2 million0.11%-16,239
Rezolute Inc. RZLT127,289$661,9030.06%-1,437
Caribou Biosciences Inc. CRBU354,687$624,2490.05%-603,100
Every US-listed position in the fund's 13F for the quarter ended 30 June 2026, by the value it reported.
Read moreChange is shares against its 13F for the quarter before; the 13 it sold out of are in the box above.

Options it reported

CompanyOptionShares under the optionsValue of those shares
Cencora, Inc. CORCalls28,100$8.0 million
Centene Corp. CNCPuts88,200$5.7 million

2 option lines. A 13F lists calls and puts by the shares they cover and what those shares were worth at the quarter's end, not what the options cost; they are not counted in the holdings above.