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GeneDx Holdings Corp.: Q3 FY2026 earnings call

What management said about Q3 FY2026, from the documents filed with the SEC on 9 November 2026: press release. Guidance figures: 1 raised, 2 lowered, 6 new, 1 kept. The quarter’s numbers.

Key takeaways

  • Revenue rose 5% to $123.1 million: The company reported revenue of $123.1 million, up 5% from $116.7 million a year earlier and up from $114.4 million in the second quarter. Source
  • Exome and genome volume rose 25%: Exome and genome test result volume reached 32,134 tests, up 25% from a year earlier, with accession growth of 28%. Source
  • Adjusted gross margin reached 72%: Adjusted gross margin was 72%, up from 70% in the second quarter and compared with 74% a year earlier. GAAP gross margin was 70%. Source
  • Adjusted net income rose to $8.6 million: Adjusted net income was $8.6 million, up $8.2 million from the second quarter and compared with $16.1 million a year earlier. Source
  • GAAP net loss was $12.3 million: GAAP net loss was $12.3 million, or $(0.41) per share, against $(0.27) a year earlier. Nine-month net loss was $93.4 million, or $(3.15) per share. Source
  • Medicaid whole genome coverage reached 25 states: Arkansas and Utah Medicaid were added, bringing state Medicaid programs covering whole genome sequencing to 25. The second-quarter release counted 39 programs covering exome and/or genome. Source
  • Cash and securities rose to $171.1 million: Cash, cash equivalents, marketable securities and restricted cash was $171.1 million at September 30, 2026, against $133.5 million at June 30. Cash and equivalents were $96.1 million. Source

“Our Q3 results reflect profitable execution in a growing market, as we translate the rising demand for exome and genome testing into durable revenue growth”

Katherine Stueland, CEO of GeneDx

Guidance

AreaPeriodFigureAgainst last quarter
Revenue SourceFull year 2026$475 to $490 millionKept
Exome and genome volume growth SourceFull year 2026At least 28% growthLowered from At least 30% growth
Exome and genome revenue growth SourceFull year 2026At least 17% growthLowered from At least 20% growth
Adjusted gross margin SourceFull year 2026Approximately 71%Raised from Approximately 70%
Adjusted net income SourceFull year 2026Approximately $12 millionNew
Revenue SourceFourth quarter 2026$135 millionNew
Exome and genome volume SourceFourth quarter 202634,500 testsNew
Exome and genome revenue SourceFourth quarter 2026$121 millionNew
Adjusted gross margin SourceFourth quarter 2026At least 71%New
Adjusted net income SourceFourth quarter 2026Approximately $12 millionNew

What changed from last quarter

  • Guidance lowered: Full-year exome and genome volume growth guidance was lowered to at least 28% from at least 30%. Source
  • Guidance lowered: Full-year exome and genome revenue growth guidance was lowered to at least 17% from at least 20%. Source
  • Guidance raised: Full-year adjusted gross margin guidance was raised to approximately 71% from approximately 70%. Source
  • Guidance kept: Full-year 2026 revenue guidance of $475 to $490 million was reiterated. Source
  • New guidance: Fourth-quarter 2026 guidance was provided for revenue, volume, exome and genome revenue, adjusted gross margin and adjusted net income. Source
  • New: Nicole Maassen, J.D. was appointed Chief Patient Access Officer to lead Market Access and Government Affairs. Source
  • New: The company announced a genome testing portfolio enhancement with long-read whole genome sequencing. Source
  • New: A new online offering lets families start exome testing for pediatric patients with GDD, ID or epilepsy. Source
  • New: A sponsored no-cost exome testing program with Mirum Pharmaceuticals was launched for eligible patients. Source
  • New: Arkansas and Utah Medicaid coverage for whole genome sequencing was added. Source
  • New: Third-party advisor fees for the Revenue Cycle Transformation were recorded in Other costs for the quarter. Source

Revenue and volume growth

  • Revenue rose 5% to $123.1 million: The company reported revenue of $123.1 million, up 5% from $116.7 million a year earlier and up from $114.4 million in the second quarter. Source
  • Exome and genome volume rose 25%: Exome and genome test result volume reached 32,134 tests, up 25% from a year earlier, with accession growth of 28%. Source
  • Exome and genome revenue rose 12%: Exome and genome test revenue was $110.4 million, up 12% year-over-year and up from $100.3 million in the second quarter. Source

Test categories and other revenue

  • Other panels revenue fell year over year: Other panels revenue was $9.7 million against $14.6 million a year earlier, and other panel volume was 26,524 against 34,514. Source
  • Data information revenue rose: Data information revenue was $2.8 million, against $2.3 million in the second quarter and $1.5 million a year earlier. Software and interpretation services revenue was $0.2 million, against $1.7 million a year earlier. Source

“Our priorities are clear: improve the economics of our testing, expand utilization, and deliver leading products at scale.”

Katherine Stueland, CEO of GeneDx

Margins, costs and earnings

  • Adjusted gross margin reached 72%: Adjusted gross margin was 72%, up from 70% in the second quarter and compared with 74% a year earlier. GAAP gross margin was 70%. Source
  • Adjusted operating expenses were 65% of revenue: Adjusted total operating expenses were $79.4 million, 65% of revenue, against $80.3 million and 70% of revenue in the second quarter. GAAP operating expenses were $96.5 million. Source
  • Adjusted net income rose to $8.6 million: Adjusted net income was $8.6 million, up $8.2 million from the second quarter and compared with $16.1 million a year earlier. Source
  • GAAP net loss was $12.3 million: GAAP net loss was $12.3 million, or $(0.41) per share, against $(0.27) a year earlier. Nine-month net loss was $93.4 million, or $(3.15) per share. Source
  • Nine-month results include $31.3 million impairment: The first-quarter impairment of $31.3 million related to goodwill and intangible assets from the Fabric Genomics acquisition, as described in the second-quarter release.
  • R&D fell while SG&A rose: Research and development expense was $17.4 million against $19.8 million a year earlier. GAAP selling, general and administrative expense was $79.1 million against $67.9 million. Source

Coverage, access and leadership

  • Medicaid whole genome coverage reached 25 states: Arkansas and Utah Medicaid were added, bringing state Medicaid programs covering whole genome sequencing to 25. The second-quarter release counted 39 programs covering exome and/or genome. Source
  • Chief Patient Access Officer appointed: Nicole Maassen, J.D. was appointed to lead Market Access and Government Affairs, with a focus on payer partnerships and timely access for children who need testing. Source
  • Mark Gardner named President earlier in 2026: The second-quarter release reported the appointment of Mark Gardner as President, to lead commercial and operations teams through the next phase of growth.

“By uniting these priorities with our clinical expertise and differentiated exome and genome capabilities, we are bringing life-changing answers to more families.”

Katherine Stueland, CEO of GeneDx

Products, programs and strategy

  • Long-read genome sequencing announced: The company announced a genome testing portfolio enhancement with long-read whole genome sequencing, aimed at expanding diagnostic capabilities. Source
  • Customer experience features launched: Features include simplified test reports, easy ordering and report guides, intended to simplify genomic testing from ordering through understanding and communicating results. Source
  • Online pediatric exome offering launched: Families can start genetic testing online, and licensed providers can order tests and deliver results without in-person visits, for pediatric patients with GDD, ID or epilepsy. Source
  • Sponsored testing programs with two partners: Mirum Pharmaceuticals and Beren Therapeutics each launched no-cost sponsored testing for eligible patients, covering exome testing for cholestasis and related conditions and genome sequencing for Niemann-Pick Disease Type C. Source
  • Revenue cycle transformation advisor fees: Other costs for the quarter included third-party advisor fees for the Revenue Cycle Transformation, which the company excludes from adjusted results. Source

Newborn screening and research

  • Rapid genome sequencing data published: Seattle Children's data, published with its clinical genetics team, indicates that broad first-tier rapid genome sequencing across inpatient pediatric units improves diagnostic rates, outcomes and efficiency. Source
  • GUARDIAN study enrolled 30,000 newborns: The GUARDIAN genomic newborn screening study has enrolled 30,000 newborns, and the company said this demonstrates feasibility and clinical value across diverse populations. Source
  • 27 abstracts presented at ASHG: GeneDx presented 27 scientific abstracts at ASHG 2026, including a machine learning platform to prioritize copy number variants and research on more than 100,000 individuals with autism. Source

Cash, debt and capital spending

  • Cash and securities rose to $171.1 million: Cash, cash equivalents, marketable securities and restricted cash was $171.1 million at September 30, 2026, against $133.5 million at June 30. Cash and equivalents were $96.1 million. Source
  • Long-term debt rose to $146.2 million: Long-term debt, net of current portion, was $146.2 million, against $96.8 million at June 30 and $48.2 million at December 31, 2025. Nine-month debt proceeds were $146.0 million, and $54.0 million was repaid to Perceptive. Source
  • Nine-month operating cash flow turned negative: Net cash used in operating activities was $72.0 million for the nine months, against $36.4 million provided a year earlier. Purchases of property and equipment and internal-use software were $21.8 million. Source
  • Blackstone loan facility expanded in August: The August 3 amendment added a $50.0 million term loan and raised the facility to $150.0 million. An affiliate of Blackstone agreed to buy about $5.0 million of Class A stock at $61.00 per share.

Coming up, as management said on 9 November 2026

  • Oregon newborn screening study over two years: GeneDx is the integrated laboratory partner in the BRIDGES-NBS study, providing genome sequencing and interpretation to screen up to 30,000 newborns over two years. Source

Earlier plans management reported on

  • Not stated: The company reiterated its full-year 2026 revenue range in this release. Source
  • Not stated: The second-quarter release guided third-quarter revenue to $122 to $124 million; this release reports $123.1 million.
  • Not stated: The second-quarter release guided third-quarter exome and genome volume to 33,200 tests; this release reports 32,134.
  • Not stated: The second-quarter release guided third-quarter adjusted net income to approximately $2 million; this release reports $8.6 million.

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.