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Immunocore Holdings plc: Q2 FY2026 earnings call

What management said about Q2 FY2026, from the documents filed with the SEC on 6 August 2026: press release. Guidance figures: 1 new, 2 kept. The quarter’s numbers.

Key takeaways

  • Q2 KIMMTRAK sales up 18%: Q2 2026 KIMMTRAK net product sales were $115.9 million, compared with $98.0 million a year earlier, per the company. Source
  • Q2 net loss $0.8 million: Q2 net loss was $0.8 million, or $0.02 per share, compared with a net loss of $10.3 million, or $0.20 per share, a year earlier. Loss from operations was $3.0 million. Source
  • Five-year survival benefit shown: Five-year OS was 16% on KIMMTRAK versus 8% in the control arm (HR 0.67). Median OS was 21.6 months versus 16.9 months. Data were presented at AACR 2026. Source
  • TEBE-AM enrollment nearing 540: TEBE-AM enrollment in previously treated advanced cutaneous melanoma is nearing the 540-patient target. The trial's primary endpoint is overall survival. Source
  • Brenetafusp 160 mcg response rate 17%: At ASCO 2026, the 160 mcg monotherapy cohort in heavily pretreated melanoma showed ORR 17% and DCR 67%, compared with ORR 6% and DCR 56% in the 40 mcg cohort. Source
  • Cash and securities $880.2 million: Cash, cash equivalents and marketable securities were $880.2 million at June 30, 2026, up from $864.2 million at December 31, 2025 and $844.9 million at March 31, 2026. Source
  • Rebate payments due second half: Management expects to pay about $120 million in sales-related rebate accruals in the second half of 2026. Source

“The five-year overall survival data for KIMMTRAK underscores the lasting impact of our medicine for patients with metastatic uveal melanoma and reinforces our confidence in the potential of our platform,”

Bahija Jallal, CEO of Immunocore

Guidance

AreaPeriodFigureAgainst last quarter
Sales-related rebate accruals SourceSecond half of 2026approximately $120 millionNew
TEBE-AM enrollment target Source2026540 patients
TEBE-AM topline data SourceEnd of 2026as early as end of 2026
Brenetafusp Phase 1/2 data (ovarian and NSCLC) SourceSecond half of 2026second half of 2026Kept
IMC-U120AI CTA or IND filing SourceSecond half of 2026second half of 2026Kept

What changed from last quarter

  • New guidance: Management gave an expected second-half 2026 payment of about $120 million in sales-related rebate accruals, which the prior release did not state. Source
  • New: Enrollment was completed at higher MAD dose cohorts, up to 1200 mcg, in the Phase 1/2 HIV trial. The prior release said enrollment was continuing at higher doses. Source
  • New: Trial sites for the IMC-S118AI Phase 1 type 1 diabetes trial are open. The prior release expected the trial to begin in the first half of 2026. Source
  • New: The company states that ASCO data support the 160 mcg dose selected for the Phase 3 PRISM-MEL-301 trial. Source
  • New: The ATOM Phase 3 adjuvant trial now has patients enrolling in the United States, following expansion of its site footprint. Source
  • New: The company is evaluating brenetafusp with bevacizumab in earlier lines of ovarian cancer, including platinum-sensitive disease. The prior release did not mention this combination. Source
  • New: Translational HIV data from the first three MAD cohorts were presented in July 2026 at the International AIDS Society meeting. Source

Results and growth drivers

  • Q2 KIMMTRAK sales up 18%: Q2 2026 KIMMTRAK net product sales were $115.9 million, compared with $98.0 million a year earlier, per the company. Source
  • Volume drove the increase: Management said the rise in net product sales was primarily due to higher volumes in the United States and international regions. Source
  • First-half sales up 16%: KIMMTRAK net product sales for the six months were $222.6 million, up 16% year over year. Q1 2026 sales were $106.7 million. Source
  • Q2 net loss $0.8 million: Q2 net loss was $0.8 million, or $0.02 per share, compared with a net loss of $10.3 million, or $0.20 per share, a year earlier. Loss from operations was $3.0 million. Source
  • Six-month net income positive: Net income for the six months was $12.2 million, or $0.23 per diluted share, compared with a net loss of $5.3 million in the same period of 2025. Source

Regional sales mix

  • US sales up 17%: US quarterly sales grew 17% year over year, and mean duration of treatment was 14 months. Source
  • Q2 regional sales split: Q2 2026 sales were $74.9 million in the United States, $34.1 million in Europe and $6.9 million in international regions. Europe was $34.4 million in Q1 2026. Source
  • Europe and International up 21%: Combined Europe and International sales rose 21% year over year, which the company attributed to increased demand. Source

“With enrollment in our Phase 3 TEBE-AM trial nearing target completion and continued progress across our pipeline, we remain focused on our mission: delivering innovative transformative medicines to improve outcomes for patients with serious diseases.”

Bahija Jallal, CEO of Immunocore

KIMMTRAK positioning and survival

  • Five-year survival benefit shown: Five-year OS was 16% on KIMMTRAK versus 8% in the control arm (HR 0.67). Median OS was 21.6 months versus 16.9 months. Data were presented at AACR 2026. Source
  • Benefit held across subgroups: Management said the OS benefit was seen regardless of baseline characteristics, including high tumor burden, elevated LDH or tumor location, and was driven primarily by KIMMTRAK rather than later therapies. Source
  • Standard of care in launched markets: Management said KIMMTRAK continues to be the standard of care in all major markets where it is launched. The prior release said most markets. Source
  • Three growth areas named: The three areas are continued US community and global penetration in metastatic uveal melanoma, potential 2L+ advanced cutaneous melanoma expansion, and potential adjuvant uveal melanoma expansion. Source

Phase 3 trial progress

  • TEBE-AM enrollment nearing 540: TEBE-AM enrollment in previously treated advanced cutaneous melanoma is nearing the 540-patient target. The trial's primary endpoint is overall survival. Source
  • PRISM-MEL-301 randomizing patients: Randomization continues 1:1 to brenetafusp 160 mcg plus nivolumab, or to a control arm of nivolumab or nivolumab plus relatlimab, in first-line advanced melanoma. Source
  • Patient population estimates: The company estimates up to 10,000 HLA-A*02:01-positive patients across the US and Europe in first-line advanced melanoma, and up to 4,000 previously treated advanced cutaneous melanoma patients. Source
  • ATOM adds US enrollment: The EORTC-sponsored adjuvant trial is expanding its sites, with patients now enrolling in the United States. The company estimates up to 1,200 eligible patients in the US and Europe. Source

Brenetafusp and PRAME early data

  • Brenetafusp 160 mcg response rate 17%: At ASCO 2026, the 160 mcg monotherapy cohort in heavily pretreated melanoma showed ORR 17% and DCR 67%, compared with ORR 6% and DCR 56% in the 40 mcg cohort. Source
  • 160 mcg dose set for Phase 3: The company states the data support the selected dose for the ongoing PRISM-MEL-301 Phase 3 trial in first-line advanced melanoma. Source
  • Monotherapy median OS 14.3 months: Median OS for brenetafusp monotherapy was 14.3 months, which management said was similar to other Phase 1/2 combination trials in heavily pretreated advanced melanoma. Source
  • Pembrolizumab combination in resistance: Brenetafusp with pembrolizumab was tested in six patients with PD1 primary resistance, with ORR 33% and DCR 67%. Source

Autoimmune and HIV programs

  • HIV higher-dose enrollment completed: Enrollment in the MAD part of the HIV Phase 1/2 trial was completed at higher doses, up to 1200 mcg. Analysis is ongoing. Source
  • HIV interferon data presented: Translational data from the first three MAD cohorts were presented in July 2026, showing interferon-associated immune programs with stronger induction in participants who maintained viral control. Source
  • IMC-S118AI trial sites open: Sites for the IMC-S118AI Phase 1 type 1 diabetes trial are open. The company expects the first patient to be dosed in the coming weeks. Source
  • Preclinical type 1 diabetes data published: Preclinical work with the University of Florida, published in Science Advances, used live human pancreas tissue slices from a recent-onset type 1 diabetes donor. Source
  • IMC-U120AI filing planned: The company plans to file a CTA or IND for IMC-U120AI, targeting dermatological diseases including atopic dermatitis, in the second half of 2026. Source

Operating expenses and costs

  • R&D up on Phase 3 studies: Q2 R&D expense was $73.9 million, up from $69.0 million. Management linked the increase to clinical programs, including three Phase 3 studies. First-half R&D was $135,058 thousand. Source
  • SG&A expense $43.9 million: Q2 SG&A expense was $43.9 million, compared with $42.8 million for Q2 2025. Source
  • Cost of revenue small: Cost of revenue from sale of therapies was $1.1 million in Q2 2026, compared with $1.0 million in Q2 2025. Source

Cash, debt and receivables

  • Cash and securities $880.2 million: Cash, cash equivalents and marketable securities were $880.2 million at June 30, 2026, up from $864.2 million at December 31, 2025 and $844.9 million at March 31, 2026. Source
  • Rebate payments due second half: Management expects to pay about $120 million in sales-related rebate accruals in the second half of 2026. Source
  • Six-month operating cash flow lower: Net cash provided by operating activities was $2.2 million for the six months, against $26.4 million a year earlier. Source
  • Receivables rise to $95.4 million: Accounts receivable, net was $95.4 million at June 30, 2026, against $74.0 million at December 31, 2025. Source
  • Loans and borrowings $394.2 million: Interest-bearing loans and borrowings were $394.2 million at June 30, 2026, compared with $393.1 million at December 31, 2025. Source

Coming up, as management said on 6 August 2026

  • IMC-S118AI first patient dosing: Management expects the first type 1 diabetes patient to be dosed in the coming weeks, with trial sites already open. Source
  • HIV higher-dose results early next year: Analysis of the higher-dose MAD data is ongoing, and results are planned to be shared early next year. Source

Figures management reported

FigureReported
KIMMTRAK net product sales, Q2 2026 Source$115.9 million
KIMMTRAK net product sales, six months 2026 Source$222.6 million
Countries where KIMMTRAK is approved Source39
R&D expense, Q2 2026 Source$73,945 thousand
R&D expense, six months 2026 Source$135,058 thousand
Brenetafusp ORR, 160 mcg monotherapy Source17%
KIMMTRAK five-year OS rate Source16% versus 8% in control arm
Phase 3 trials enrolling SourceTEBE-AM nearing 540-patient target

Risks management discussed

  • Operational: Timing of TEBE-AM topline data depends on the trial reaching its event-driven endpoint, which management described as the basis for its timing. Source
  • Regulatory: The safety information reports cytokine release syndrome in 89% of KIMMTRAK patients, with 0.8% grade 3 or 4, and a boxed warning for CRS. Source

Earlier plans management reported on

  • Not stated: The prior release expected TEBE-AM enrollment to complete in the first half of 2026. The current release says enrollment is nearing the 540-patient target.
  • Not stated: The prior release expected the Phase 1 trial to begin in the first half of 2026. The current release says trial sites are open and the first dosing is expected in coming weeks.
  • Not stated: The prior release expected additional Phase 1 MAD data in the second half of 2026. The current release says results are planned to be shared early next year.
  • Not stated: The prior release planned the IMC-U120AI filing for the second half of 2026. The current release restates the same timing.

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.