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Immunocore Holdings plc: Q1 FY2026 earnings call

What management said about Q1 FY2026, from the documents filed with the SEC on 6 May 2026: press release. Guidance figures: 6 kept. The quarter’s numbers.

Key takeaways

  • KIMMTRAK sales rose 13.6%: Net product sales were $106.7 million against $93.9 million a year earlier. The company attributed the increase to higher volumes in the US and Europe and to global country expansion. Source
  • US sales grew 19.1%: US sales were $67.4 million, with mean duration of treatment at 14 months. US growth in the prior quarter was 13%. Source
  • Five-year survival data at AACR: The five-year OS rate was 16% versus 8% in the control arm (HR 0.67). Median OS was 21.6 months against 16.9 months for investigator's choice. Source
  • PRISM-MEL-301 enrolling first-line melanoma: Brenetafusp 160 mcg with nivolumab is compared with nivolumab or nivolumab plus relatlimab. The company estimates 10,000 HLA-A*02:01 positive patients in the US and Europe. Source
  • R&D rose on Phase 3 costs: R&D expense was $61.1 million against $56.5 million a year earlier. The company cited clinical expenses for progression of its Phase 3 trials, mainly PRISM-MEL-301. Source
  • Cash and securities of $844.9 million: Cash, cash equivalents and marketable securities were $844.9 million, against $864.2 million at December 31, 2025. Source

“The five-year overall survival (OS) data from our Phase 3 trial presented at AACR is a landmark moment.”

Bahija Jallal, CEO of Immunocore

Guidance

AreaPeriodFigureAgainst last quarter
TEBE-AM enrollment and topline data SourceEnrollment completion in 1H 2026; topline data as early as 2H 2026Enrollment completion in the first half of 2026; topline data as early as the second half of 2026Kept
Brenetafusp Phase 1/2 data and IMC-P115C Source2H 2026Phase 1/2 data from both trials in the second half of 2026Kept
HIV Phase 1 MAD data (IMC-M113V) Source2H 2026Additional Phase 1 MAD data in the second half of 2026Kept
IMC-S118AI Phase 1 start (autoimmune) Source1H 2026Phase 1 trial start in the first half of 2026Kept
IMC-U120AI CTA or IND filing (autoimmune) Source2H 2026Filing in the second half of 2026Kept
IMC-R117C initial data Source2027Initial data in 2027Kept

What changed from last quarter

  • New: Five-year OS data from the Phase 3 trial were presented in an oral session at AACR 2026. The prior release did not list this presentation. Source

Results and growth drivers

  • KIMMTRAK sales rose 13.6%: Net product sales were $106.7 million against $93.9 million a year earlier. The company attributed the increase to higher volumes in the US and Europe and to global country expansion. Source
  • Net income and EPS both rose: Net income was $13.0 million and diluted EPS $0.25, against $5.0 million and $0.10 in Q1 2025. Source
  • Growth rate below fourth-quarter pace: Fourth-quarter 2025 KIMMTRAK sales grew 24% year over year. Full-year 2025 sales were $400.0 million, up 29%.

Segments and regions

  • US sales grew 19.1%: US sales were $67.4 million, with mean duration of treatment at 14 months. US growth in the prior quarter was 13%. Source
  • Europe sales grew 4.9%: Europe sales were $34.4 million. Europe growth in the prior quarter was 79%; the company cited increased demand and launches in European markets. Source
  • International sales of $4.8 million: International regions contributed $4.8 million of first-quarter sales, following global country expansion. Source

“It is the longest OS follow-up ever reported in a randomized trial in metastatic uveal melanoma and underscores the long-term benefit KIMMTRAK delivers to patients.”

Bahija Jallal, CEO of Immunocore

KIMMTRAK indications and trial data

  • Five-year survival data at AACR: The five-year OS rate was 16% versus 8% in the control arm (HR 0.67). Median OS was 21.6 months against 16.9 months for investigator's choice. Source
  • Benefit held across risk groups: The company said the OS benefit appeared regardless of high tumor burden, elevated LDH, tumor location, and progressive disease as best response. Source
  • Most control patients later got KIMMTRAK: Among KIMMTRAK patients alive at five years, 44% received only KIMMTRAK. Among control-arm patients alive at that point, 86% later received KIMMTRAK. Source
  • Three growth areas for KIMMTRAK: Growth areas are US community and global penetration in metastatic uveal melanoma, 2L+ advanced cutaneous melanoma, and adjuvant uveal melanoma. Source
  • Up to 4,000 CM patients estimated: The company estimates up to 4,000 previously treated advanced CM patients could be addressed. It estimates up to 1,200 high-risk adjuvant uveal patients in the US and Europe. Source

Pipeline programs and milestones

  • PRISM-MEL-301 enrolling first-line melanoma: Brenetafusp 160 mcg with nivolumab is compared with nivolumab or nivolumab plus relatlimab. The company estimates 10,000 HLA-A*02:01 positive patients in the US and Europe. Source
  • Brenetafusp ovarian trial continuing: Brenetafusp is combined in platinum-resistant and platinum-sensitive ovarian cancer. Metastatic NSCLC cohorts continue in the same trial. Source
  • HIV trial dose escalation continues: The multiple ascending dose part of the IMC-M113V Phase 1/2 trial is dosing at higher levels to identify a safe and tolerable dose, for a functional cure candidate. Source
  • Two autoimmune candidates advancing: Candidates target type 1 diabetes and inflammatory dermatological diseases. The company filed a CTA for IMC-S118AI in December 2025. Source
  • IMC-R117C colorectal trial enrolling: The Phase 1/2 dose escalation trial covers advanced solid tumors including colorectal cancer, given alone and combined with standards of care. Source

“In parallel, we are executing with discipline across our pipeline.”

Bahija Jallal, CEO of Immunocore

Research, development and SG&A costs

  • R&D rose on Phase 3 costs: R&D expense was $61.1 million against $56.5 million a year earlier. The company cited clinical expenses for progression of its Phase 3 trials, mainly PRISM-MEL-301. Source
  • SG&A fell on share-based forfeitures: SG&A was $37.9 million against $40.2 million a year earlier. The company attributed the decrease to higher forfeitures of share-based compensation. Source
  • Operating income of $7.3 million: Income from operations was $7.3 million against a loss of $3.6 million a year earlier. Cost of revenue was $0.4 million against $0.8 million. Source

Cash, debt and balance sheet

  • Cash and securities of $844.9 million: Cash, cash equivalents and marketable securities were $844.9 million, against $864.2 million at December 31, 2025. Source
  • Operating cash outflow in quarter: Operating activities used $13.8 million, against $0.4 million provided in Q1 2025. Investing activities provided $4.2 million. Source
  • Borrowings and equity both $393.7 million: Interest-bearing loans and borrowings were $393.7 million at March 31, 2026. Total shareholders' equity was $393.7 million. Source

Coming up, as management said on 6 May 2026

  • Brenetafusp Phase 1 poster at ASCO: Poster board 243 on May 31, 2026, 9:00 AM to 12:00 PM CDT, covering Phase 1 evaluation of brenetafusp in advanced melanoma. Source
  • IL-7 T-cell poster at ASCO: Poster board 452 on May 30, 2026, 1:30 to 4:30 PM CDT, covering IL7 effects on ImmTAC-mediated killing by T cells. Source

Figures management reported

FigureReported
KIMMTRAK net product sales, Q1 2026 Source$106.7 million
KIMMTRAK net sales growth, year over year Source13.6%
R&D expense, Q1 2026 Source$61.1 million
Countries where KIMMTRAK is approved Source39
ATOM Phase 3 planned enrollment Source290 patients

Earlier plans management reported on

  • On track: The prior release stated TEBE-AM enrollment remains on track for completion in the first half of 2026. The current release gives the same timing.

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.