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Halozyme Therapeutics, Inc.: Q3 FY2026 earnings call

What management said about Q3 FY2026, from the documents filed with the SEC on 5 November 2026: press release. Guidance figures: 4 raised. The quarter’s numbers.

Key takeaways

  • Total revenue up 39%: Total revenue was $493.0 million, up from $354.3 million, primarily from royalty revenue growth and higher product sales. Source
  • Royalties rose 44% to $341 million: Royalty revenue was $341.0 million, up from $236.0 million, driven mainly by partner products launched since 2020, including VYVGART Hytrulo, DARZALEX SC and Phesgo. Source
  • Argenx and Incyte deals expanded: Agreements with argenx and Incyte added targets for ENHANZE evaluation. Incyte also expanded to evaluate a SC formulation of axatilimab, with an upfront payment. Source
  • Three ENHANZE programs entered Phase 1: Programs with Pfizer, Incyte and argenx advanced into Phase 1, bringing total products in development to twelve. Source
  • Dutch court enjoined Keytruda Qlex: The Dutch court found MSD BV infringing an MDASE patent and ordered it to stop Keytruda Qlex in eight European countries. Source
  • Cash rose to $1.08 billion: Cash, cash equivalents, restricted cash and marketable securities were $1.08 billion, up from $145.4 million at December 31, 2025. Source

“Halozyme delivered another exceptional quarter, with total revenue increasing 39% and royalty revenue growing 44% year-over-year to record levels,”

Dr. Helen Torley, President and Chief Executive Officer

Guidance

AreaPeriodFigureAgainst last quarter
Total revenue SourceFull year 2026$1.860 billion to $1.925 billionRaised from $1.835 to $1.910 billion
Royalty revenue SourceFull year 2026$1.235 billion to $1.255 billionRaised from $1.220 to $1.245 billion
Adjusted EBITDA SourceFull year 2026$1.240 billion to $1.290 billionRaised from $1.225 to $1.280 billion
Non-GAAP diluted EPS SourceFull year 2026$8.75 to $9.05Raised from $8.65 to $9.00

What changed from last quarter

  • Guidance raised: The 2026 guidance ranges for total revenue, royalty revenue, adjusted EBITDA and non-GAAP diluted EPS were raised; the prior ranges were last updated August 6, 2026. Source
  • New: The company reported completing $1.5 billion of convertible notes in the quarter. Source
  • New: The Dutch court injunction on Keytruda Qlex in eight European countries was announced in October 2026. Source
  • New: argenx nominated two additional targets in September 2026, bringing the total under its ENHANZE access to eight. Source
  • New: Janssen expanded its collaboration in October 2026 for one additional oncology target to be developed with ENHANZE. Source
  • New: Surf Bio's hyperconcentration technology was recently renamed Aerocon. Source

Results and growth drivers

  • Total revenue up 39%: Total revenue was $493.0 million, up from $354.3 million, primarily from royalty revenue growth and higher product sales. Source
  • Net income higher year over year: Net income was $247.0 million, up from $175.2 million; operating income rose to $295.0 million from $217.9 million. Source
  • Non-GAAP diluted EPS reached $2.39: Non-GAAP diluted EPS was $2.39, compared with $1.72 a year earlier. GAAP diluted EPS was $2.01, compared with $1.43. Source

Revenue streams

  • Royalties rose 44% to $341 million: Royalty revenue was $341.0 million, up from $236.0 million, driven mainly by partner products launched since 2020, including VYVGART Hytrulo, DARZALEX SC and Phesgo. Source
  • Product sales increased to $137 million: Product sales, net were $137.3 million, up from $94.2 million. The 2026 guidance also cites product sales from API as a driver. Source
  • Collaboration revenue fell to $14.6 million: Revenues under collaborative agreements were $14.6 million, compared with $24.0 million in the third quarter of 2025. Source

“Our commitment to protecting the value of our innovations, growing royalties, continued partner expansion and growing pipeline demonstrates the power of Halozyme’s compounding platform engine and positions us to deliver durable revenue well into the next decade.”

Dr. Helen Torley, President and Chief Executive Officer

Partner programs and deals

  • Argenx and Incyte deals expanded: Agreements with argenx and Incyte added targets for ENHANZE evaluation. Incyte also expanded to evaluate a SC formulation of axatilimab, with an upfront payment. Source
  • Three ENHANZE programs entered Phase 1: Programs with Pfizer, Incyte and argenx advanced into Phase 1, bringing total products in development to twelve. Source
  • Janssen expanded agreement in October: The CEO referred to an expanded agreement with Johnson & Johnson for one additional target, signed in October. The partner highlights name Janssen. Source
  • Partner approval milestones this quarter: Roche reported FDA approval of TECENTRIQ and TECENTRIQ HYBREZA for adjuvant dMMR colon cancer. argenx submitted a supplemental BLA for VYVGART in ocular myasthenia gravis. Source

Patent litigation and injunction

  • Dutch court enjoined Keytruda Qlex: The Dutch court found MSD BV infringing an MDASE patent and ordered it to stop Keytruda Qlex in eight European countries. Source
  • Court rejected invalidity argument: The court rejected MSD BV's arguments that the Halozyme patent is invalid. Source
  • Litigation costs excluded from adjusted measures: Intellectual property litigation costs of $7.5 million were excluded from adjusted EBITDA, up from $6.0 million a year earlier; the company does not view them as ongoing business. Source

“We completed $400 million in share repurchases this year while continuing to invest in our highest-return organic opportunities”

Darren Snellgrove, Executive Vice President and Chief Financial Officer

Costs and expenses

  • Cost of sales rose on bulk sales: Cost of sales was $82.5 million, compared with $55.2 million, primarily due to higher bulk rHuPH20 sales. Source
  • Amortization rose after Elektrofi deal: Amortization of intangibles was $29.5 million, compared with $17.8 million, reflecting the Elektrofi acquisition completed in November 2025. Source
  • R&D and SG&A increased: R&D was $27.8 million, up from $17.3 million. SG&A was $58.2 million, up from $46.1 million, including consulting, litigation and compensation costs. Source
  • Interest and tax expense: Interest expense was $6.0 million, compared with $4.3 million. Income tax expense was $43.6 million, compared with $43.7 million. Source

Earnings and non-GAAP measures

  • EBITDA and adjusted EBITDA higher: Adjusted EBITDA was $336.2 million, compared with $248.2 million in the third quarter of 2025. Source
  • Non-GAAP net income adjustments: Non-GAAP net income was $283.8 million, after adding back share-based compensation of $16.8 million and intangible amortization of $29.5 million. Source
  • Diluted share count excluded convertible notes: GAAP diluted shares were 122.6 million; the non-GAAP calculation removed the dilutive effect of convertible notes, leaving 118.9 million. Source

Cash, debt and share repurchases

  • Cash rose to $1.08 billion: Cash, cash equivalents, restricted cash and marketable securities were $1.08 billion, up from $145.4 million at December 31, 2025. Source
  • Long-term debt reached $2.94 billion: Long-term debt, net was $2.94 billion, with $305.6 million classified as current at September 30, 2026. Source
  • Share repurchases of $67.2 million: The company repurchased about 0.8 million shares in the quarter under the May 2026 program. Source

Strategy and technology platform

  • Hypercon licensed to five partners: The company said Hypercon has been licensed to Janssen, Eli Lilly, argenx, Vertex and Oruka. Source
  • ENHANZE in ten commercial products: The company said ENHANZE is used in ten commercialized products across more than 100 global markets. Source
  • Aerocon may broaden biologics range: The company said the Aerocon polymer-based hyperconcentration technology may further broaden the range of biologics that can be delivered subcutaneously. Source

Coming up, as management said on 5 November 2026

  • Janssen priority review of head and neck filing: The FDA granted priority review of the sBLA for SC amivantamab in head and neck squamous cell carcinoma. The release gives no action date. Source
  • GSK Phase 1b belantamab study planned: GSK disclosed plans to start a Phase 1b study comparing a SC belantamab formulation with ENHANZE against IV belantamab in multiple myeloma. Source
  • Takeda BLA for TAK-881 pending: Takeda filed a BLA with the FDA for TAK-881 in Primary Immunodeficiency Disease. The release gives no decision date. Source

Figures management reported

FigureReported
Royalty revenue Source$341.0 million
Product sales, net Source$137.3 million
Research and development expense Source$27.8 million
Products in development Sourcetwelve
FDA approval, TECENTRIQ adjuvant dMMR colon cancer SourceApproved; twelfth U.S. indication for TECENTRIQ
BLA filed, TAK-881 (Takeda) SourceFiled with FDA for Primary Immunodeficiency Disease

Risks management discussed

  • External: Management cited litigation costs from a patent infringement case as a driver of the SG&A increase. Source

Earlier plans management reported on

  • Met: An earlier expectation of at least $400 million of 2026 buybacks. The current release says $400 million of repurchases was completed.
  • Not stated: Management said it maintains a clear path to retire the remaining 2027 and 2028 notes at maturity. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.