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Halozyme Therapeutics, Inc.: Q1 FY2026 earnings call

What management said about Q1 FY2026, from the documents filed with the SEC on 11 May 2026: press release. Guidance figures: 2 new, 6 kept. The quarter’s numbers.

Key takeaways

  • Total revenue rose to $376.7 million: Total revenue was $376.7 million, up 42% year over year. The company attributed the increase primarily to royalty revenue growth and higher product sales. Source
  • Royalties rose 43 percent: Royalty revenue was $240.7 million, driven by ENHANZE partner products launched since 2020, predominantly DARZALEX SC, VYVGART Hytrulo and Phesgo. Source
  • VYVGART Hytrulo approved for all gMG serotypes: Management said the FDA approval of VYVGART Hytrulo for all serotypes of gMG represents a significant expansion of addressable patients. Source
  • Three new collaborations signed after quarter end: Management cited three new collaboration and licensing agreements with Vertex, Oruka and GSK, signed in April and May 2026. Source
  • ENHANZE products in development rising: Two new Phase 1 study starts raised ENHANZE products in development to nine, with 13 expected by year-end 2026. Source
  • Merck patent litigation costs excluded: Intellectual property litigation costs of $11.2 million were excluded from adjusted EBITDA and non-GAAP results, as the company does not view them as reflective of ongoing operations. Source
  • Up to $1 billion buyback through 2028: The company announced a share repurchase program of up to $1 billion of common stock by December 31, 2028. Source

“I am pleased to announce our new $1 billion share repurchase program and that we project to repurchase at least $400 million in 2026”

Dr. Helen Torley, President and Chief Executive Officer of Halozyme

Guidance

AreaPeriodFigureAgainst last quarter
Total revenue Sourcefull year 2026$1.710 billion to $1.810 billionKept
Royalty revenue Sourcefull year 2026$1.130 billion to $1.170 billionKept
Adjusted EBITDA Sourcefull year 2026$1.125 billion to $1.205 billionKept
Non-GAAP diluted EPS Sourcefull year 2026$7.75 to $8.25Kept
Hypercon and Surf Bio investment Sourcefull year 2026approximately $60 millionKept
Share repurchases Sourcefull year 2026at least $400 millionNew
Share repurchase program Sourcethrough December 31, 2028up to $1 billionNew
ENHANZE royalty revenue Sourcefull year 2026exceed $1 billionKept
ENHANZE products in development Sourceyear-end 202613

What changed from last quarter

  • Guidance kept: 2026 financial guidance ranges were reiterated, and the company said they were last provided on February 17, 2026. Source
  • New: New share repurchase program of up to $1 billion, running through December 31, 2028. Source
  • New: Vertex agreement in April 2026 gives Vertex access to Hypercon technology for up to three targets, with an upfront payment of $15 million. Source
  • New: Oruka agreement in May 2026 covers Hypercon technology for ORKA-001 and one additional target, with an upfront payment and mid-single digit royalties. Source
  • New: GSK agreement in May 2026 covers ENHANZE for multiple oncology targets, including first potential use with antibody drug conjugates. Source

Results and growth drivers

  • Total revenue rose to $376.7 million: Total revenue was $376.7 million, up 42% year over year. The company attributed the increase primarily to royalty revenue growth and higher product sales. Source
  • Operating income and net income increased: Operating income was $184.5 million and net income was $150.0 million, against $141.5 million and $118.1 million a year earlier. Source
  • Adjusted EBITDA reached $229.5 million: EBITDA was $218.3 million and adjusted EBITDA was $229.5 million, compared with $162.0 million for both measures a year earlier. Adjusted EBITDA excludes intellectual property litigation costs. Source
  • Diluted EPS rose on both bases: GAAP diluted EPS was $1.22 against $0.93, and non-GAAP diluted EPS was $1.60 against $1.11. Source

Revenue by stream

  • Royalties rose 43 percent: Royalty revenue was $240.7 million, driven by ENHANZE partner products launched since 2020, predominantly DARZALEX SC, VYVGART Hytrulo and Phesgo. Source
  • Product sales rose to $130.4 million: Product sales, net were $130.4 million, against $78.0 million a year earlier. Management cited the rise in product sales as a driver of total revenue growth. Source
  • Collaboration revenue declined: Revenue under collaborative agreements was $5.6 million, against $18.6 million a year earlier. Source

“This continued performance and progress resulted in strong first quarter financial results and we are pleased to reaffirm our 2026 outlook”

Dr. Helen Torley, President and Chief Executive Officer of Halozyme

Partner products and approvals

  • VYVGART Hytrulo approved for all gMG serotypes: Management said the FDA approval of VYVGART Hytrulo for all serotypes of gMG represents a significant expansion of addressable patients. Source
  • Positive ocular myasthenia gravis Phase 3 data: Positive Phase 3 data in ocular myasthenia gravis were reported to increase the MG addressable market by about 7,000 patients in the U.S. alone. Source
  • DARZALEX Faspro gains two indications: DARZALEX Faspro received its 12th and 13th approved indications and expanded into newly diagnosed and early second line multiple myeloma. Source
  • TAK-881 Phase 2/3 data may add launch: Takeda reported positive Phase 2/3 data for TAK-881 in primary immune deficiency, which management said creates the potential for an 11th ENHANZE product launch. Source
  • Janssen gains European self-administration approval: In March 2026, the European Committee for Medicinal Products for Human Use granted approval for self or caregiver administration of the DARZALEX SC formulation. Source

Pipeline and new deals

  • Three new collaborations signed after quarter end: Management cited three new collaboration and licensing agreements with Vertex, Oruka and GSK, signed in April and May 2026. Source
  • ENHANZE products in development rising: Two new Phase 1 study starts raised ENHANZE products in development to nine, with 13 expected by year-end 2026. Source
  • First approvals projected from 2029: Management projects potential ENHANZE product approvals beginning in 2029 and first Hypercon approvals in the 2030/2031 period. Source

“The growing number of indications for our approved products and new Phase 3 data milestones represent increased opportunity for ENHANZE.”

Dr. Helen Torley, President and Chief Executive Officer of Halozyme

Costs and litigation

  • Cost of sales rose on bulk sales: Cost of sales was $79.2 million, against $48.4 million, which the company attributed to higher bulk rHuPH20 sales. Source
  • Amortization rose after Elektrofi deal: Amortization of intangibles was $29.5 million, against $17.8 million, reflecting the Elektrofi acquisition completed in November 2025. Source
  • R&D expense rose with acquisitions: Research and development expense was $25.6 million, against $14.8 million, which the company linked to the Elektrofi and Surf Bio acquisitions. Source
  • SG&A rose on fees and litigation: SG&A was $57.9 million, against $42.4 million. Increases were attributed to consulting and professional fees, including patent litigation, acquisitions and compensation. Source
  • Merck patent litigation costs excluded: Intellectual property litigation costs of $11.2 million were excluded from adjusted EBITDA and non-GAAP results, as the company does not view them as reflective of ongoing operations. Source

Cash, debt and share repurchases

  • Cash and securities rose to $320.9 million: Cash, restricted cash and marketable securities increased from $145.4 million at December 31, 2025, which management attributed primarily to cash generated from operations. Source
  • Current debt portion of $208.7 million: Current portion of long-term debt was $208.7 million at March 31, 2026, with none shown at December 31, 2025. Long-term debt, net was $1,935.9 million. Source
  • Up to $1 billion buyback through 2028: The company announced a share repurchase program of up to $1 billion of common stock by December 31, 2028. Source
  • At least $400 million expected in 2026: Management expects to buy back at least $400 million of shares in 2026, a figure not included in the EPS guidance. Source
  • Diluted share count declined: Diluted weighted average shares were 122.9 million, against 126.6 million a year earlier. Source

Coming up, as management said on 11 May 2026

  • Buy back at least $400m in 2026: Company expects to repurchase at least $400 million of shares in 2026 under a program of up to $1 billion through December 31, 2028. Source
  • 13 ENHANZE products by year-end: Management expects 13 ENHANZE products in development by year-end 2026. Source
  • Possible 11th ENHANZE product launch: TAK-881 positive Phase 2/3 data could lead to an 11th ENHANZE product launch. Source
  • Hypercon approvals projected 2030 to 2031: Management projects first approvals for the five signed Hypercon agreements in the 2030/2031 time period. Source
  • ENHANZE approvals from 2029: Management projects potential approvals for ENHANZE products beginning in 2029 and later. Source

Figures management reported

FigureReported
Royalty revenue Source$240.7 million
Product sales, net Source$130.4 million
Research and development expense Source$25.6 million
ENHANZE products in development Sourcenine
Approval: VYVGART Hytrulo in gMG SourceFDA-approved for all serotypes
Phase 3 readout: ocular myasthenia gravis Sourcepositive
Phase 2/3 readout: TAK-881 Sourcepositive topline results
DARZALEX Faspro approved indications Source12th and 13th

Risks management discussed

  • Regulatory: Management discussed ongoing patent infringement litigation against Merck and the associated legal costs, which it excluded from adjusted EBITDA. Source

Earlier plans management reported on

  • Not stated: Management reiterated the 2026 guidance ranges, which were first provided on February 17, 2026. Source
  • Not stated: Management said the company has the potential to exceed its goal of three new SC delivery platform deals in 2026. Source
  • On track: Management said the company is well on its way to the expected 13 ENHANZE products in development by year-end 2026. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.