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Halozyme Therapeutics, Inc.: Q2 FY2026 earnings call

What management said about Q2 FY2026, from the documents filed with the SEC on 6 August 2026: press release. Guidance figures: 4 raised, 2 kept. The quarter’s numbers.

Key takeaways

  • Revenue rose 48% to $481.0 million: Total revenue was $481.0 million, up from $325.7 million a year earlier. The increase was primarily driven by royalty revenue growth and higher product sales. Source
  • Royalties drove most of the growth: Royalty revenue was $307.7 million, up 50% from $205.6 million, and made up most of total revenue for the quarter. Source
  • Total revenue guidance raised: Full-year total revenue is now expected at $1.835 billion to $1.910 billion, up from $1.710 billion to $1.810 billion. Source
  • Adjusted EBITDA guidance raised: Adjusted EBITDA is now expected at $1.225 billion to $1.280 billion, up from $1.125 billion to $1.205 billion, including about $60 million of Hypercon and Surf Bio investment. Source
  • Non-GAAP EPS guidance raised: Non-GAAP diluted EPS is now expected at $8.65 to $9.00, up from $7.75 to $8.25. The range does not include potential future share repurchases. Source
  • Five collaborations signed, incl. Vertex: Vertex signed in April 2026 for Hypercon, covering up to three targets, with a $15 million upfront payment. Five collaborations were signed through July across ENHANZE and Hypercon. Source
  • Repurchased $332.8 million of shares: The company repurchased 4.8 million shares for $332.8 million, averaging $69.30 per share, under the May 2026 and February 2024 programs. Source

“Based on these record results, we are raising our full year 2026 financial guidance.”

Dr. Helen Torley, President and Chief Executive Officer

Guidance

AreaPeriodFigureAgainst last quarter
Total revenue Sourcefull year 2026$1.835 billion to $1.910 billionRaised from $1.710 billion to $1.810 billion
Royalty revenue Sourcefull year 2026$1.220 billion to $1.245 billionRaised from $1.130 billion to $1.170 billion
Adjusted EBITDA Sourcefull year 2026$1.225 billion to $1.280 billionRaised from $1.125 billion to $1.205 billion
Non-GAAP diluted EPS Sourcefull year 2026$8.65 to $9.00Raised from $7.75 to $8.25
Hypercon and Surf Bio investment Sourcefull year 2026approximately $60 millionKept
Share repurchases Source2026at least $400 millionKept

What changed from last quarter

  • Guidance raised: Full-year guidance ranges raised for total revenue, royalty revenue, adjusted EBITDA and non-GAAP diluted EPS, from ranges last given on May 11, 2026. Source
  • New: Collaboration with an undisclosed company signed in May 2026 to use ENHANZE for a nucleic acid therapeutic, the first such license. Source
  • New: Global collaboration with Incyte signed in July 2026 to evaluate subcutaneous formulations of INCA033989 using ENHANZE, in mutCALR-expressing myeloproliferative neoplasms. Source
  • New: ARGX-119 adimanebart program expanded in the third quarter of 2026 to include a Phase 1 subcutaneous bioavailability study with ENHANZE. Source
  • Ended: The February 2024 share repurchase program was completed in June 2026. Source

Results and growth drivers

  • Revenue rose 48% to $481.0 million: Total revenue was $481.0 million, up from $325.7 million a year earlier. The increase was primarily driven by royalty revenue growth and higher product sales. Source
  • Royalties drove most of the growth: Royalty revenue was $307.7 million, up 50% from $205.6 million, and made up most of total revenue for the quarter. Source
  • Operating and net income increased: Operating income was $287.7 million, against $202.4 million. GAAP diluted EPS was $1.90, against $1.33 a year earlier. Source
  • Non-GAAP EPS and adjusted EBITDA rose: Adjusted EBITDA was $328.8 million, against $225.5 million. Non-GAAP diluted EPS was $2.28, against $1.54. Source

Products and partner sales

  • Product sales increased year over year: Product sales, net were $129.6 million, against $81.5 million, and contributed to the 48% increase in total revenue. Source
  • Partner product launches drove royalties: Royalty growth was attributed to continued uptake of partner products launched since 2020, predominantly VYVGART Hytrulo by argenx and DARZALEX SC by Janssen, plus other recent launches. Source
  • Collaboration revenue rose: Revenues under collaborative agreements were $43.7 million, against $38.6 million in the second quarter of 2025. Source

“Overall, these results illustrate our continued ability to create multiple waves of revenue opportunities that will drive long-term shareholder value”

Dr. Helen Torley, President and Chief Executive Officer

Costs and margins

  • Cost of sales rose with bulk sales: Cost of sales was $79.2 million, against $46.4 million, primarily due to higher bulk rHuPH20 sales. Source
  • Acquisitions lifted amortization and R&D: Amortization of intangibles was $29.5 million, against $17.8 million, from the Elektrofi acquisition. R&D was $27.7 million, against $17.5 million, mainly from Elektrofi and Surf Bio. Source
  • SG&A rose on consulting and litigation: SG&A was $57.0 million, against $41.6 million, mainly from consulting and professional fees, litigation costs, the Elektrofi and Surf Bio acquisitions, and higher compensation. Source

Guidance for 2026 raised

  • Total revenue guidance raised: Full-year total revenue is now expected at $1.835 billion to $1.910 billion, up from $1.710 billion to $1.810 billion. Source
  • Royalty revenue guidance raised: Full-year royalty revenue is now expected at $1.220 billion to $1.245 billion, up from $1.130 billion to $1.170 billion. Source
  • Adjusted EBITDA guidance raised: Adjusted EBITDA is now expected at $1.225 billion to $1.280 billion, up from $1.125 billion to $1.205 billion, including about $60 million of Hypercon and Surf Bio investment. Source
  • Non-GAAP EPS guidance raised: Non-GAAP diluted EPS is now expected at $8.65 to $9.00, up from $7.75 to $8.25. The range does not include potential future share repurchases. Source

“We have also demonstrated our commitment to returning significant capital to shareholders, repurchasing $333 million of shares in 2Q 2026, at an average price of $69.30.”

Dr. Helen Torley, President and Chief Executive Officer

New partner agreements and pipeline

  • Five collaborations signed, incl. Vertex: Vertex signed in April 2026 for Hypercon, covering up to three targets, with a $15 million upfront payment. Five collaborations were signed through July across ENHANZE and Hypercon. Source
  • GSK deal covers oncology targets: GSK made an upfront payment for ENHANZE across multiple oncology targets, including the first potential application in antibody-drug conjugates. Source
  • Oruka Hypercon license for psoriasis: Oruka licensed Hypercon for ORKA-001, in development for psoriasis and related inflammatory diseases, plus one additional target, with mid-single digit royalties. Source
  • Takeda reports positive TAK-881 data: Takeda reported positive topline results from its pivotal Phase 2/3 trial of TAK-881 with ENHANZE in primary immunodeficiency disease. Source
  • Viatris starts selatogrel study: Viatris initiated a Phase 1 study of selatogrel in Chinese adults with chronic coronary syndrome, evaluating a single dose. Source

Capital and share repurchases

  • Repurchased $332.8 million of shares: The company repurchased 4.8 million shares for $332.8 million, averaging $69.30 per share, under the May 2026 and February 2024 programs. Source
  • New $1 billion buyback through 2028: A new program authorizes repurchases of up to $1.0 billion of common stock through December 31, 2028, announced in May 2026. Source
  • Cash and securities rose: Cash, cash equivalents, restricted cash and marketable securities were $231.9 million at June 30, 2026, up from $145.4 million at December 31, 2025, mainly from operations. Source
  • Debt reclassified as current: Current portion of long-term debt was $209.0 million, and long-term debt was $1.94 billion, down from $2.14 billion at December 31, 2025. Source

Coming up, as management said on 6 August 2026

  • Incyte may nominate more targets: Incyte holds an option to nominate up to two additional targets for use with ENHANZE under the July 2026 collaboration. Source

Figures management reported

FigureReported
Royalty revenue Source$307.7 million, up 50%
Product sales, net Source$129.6 million
Revenues under collaborative agreements Source$43.7 million
Research and development expense Source$27.7 million
Commercialized ENHANZE products Sourceten
Partner FDA approval SourceVYVGART Hytrulo, gMG all serotypes
Pivotal trial readout SourceTAK-881 positive topline, Phase 2/3

Risks management discussed

  • External: Patent infringement litigation against Merck generates legal costs, which the company reports within SG&A and excludes from adjusted EBITDA. Source

Earlier plans management reported on

  • Ahead: Management says five collaborations signed year to date exceed the full-year goal of three. Source
  • Not stated: Management restated its expectation of repurchasing at least $400 million of shares in 2026. The documents give no status against it beyond the second quarter repurchases. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.