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TG Therapeutics, Inc.: Q4 FY2025 earnings call

What management said about Q4 FY2025, from the documents filed with the SEC on 26 February 2026: press release. Guidance figures: 5 new. The quarter’s numbers.

Key takeaways

  • Total revenue reached $192.6 million in Q4: Fourth-quarter total revenue was $192.6 million and full-year total revenue was $616.3 million, including BRIUMVI U.S. net revenue. Source
  • Q4 BRIUMVI U.S. sales reached $182.7 million: Q4 BRIUMVI U.S. net product revenue was $182.7 million, approximately 20% above Q3 2025. Source
  • Full-year U.S. sales up 92%: Full-year BRIUMVI U.S. net product revenue was $594.1 million, approximately 92% higher than the prior year. Source
  • Net income includes non-recurring tax benefit: Net income was $23.0 million for Q4 and $447.2 million for the year, the annual figure including a non-recurring $339.8 million tax benefit from the Q3 2025 valuation allowance release. Source
  • Subcutaneous Phase 3 about 75% enrolled: Enrollment in the Phase 3 pivotal program for subcutaneous ublituximab reached approximately 75%. Source
  • Cash reached $199.5 million at year-end: Cash, cash equivalents and investment securities were $199.5 million at December 31, 2025, against $178.3 million at September 30, 2025 and $311,001 thousand at December 31, 2024. Source

“BRIUMVI delivered significant year-over-year growth in the U.S., supported by increasing adoption and expanding global availability, while we advanced multiple late-stage clinical programs and strengthened our financial position.”

Michael S. Weiss, the Company's Chairman and Chief Executive Officer

Guidance

AreaPeriodFigureAgainst last quarter
Total global revenue Sourcefull year 2026approximately $875-900 millionNew
BRIUMVI U.S. net product revenue Sourcefull year 2026approximately $825-$850 millionNew
BRIUMVI U.S. net product revenue Sourcefirst quarter 2026approximately $185-$190 millionNew
Operating expense (R&D and SG&A, excluding non-cash compensation) Sourcefull year 2026approximately $350 millionNew
Subcutaneous BRIUMVI manufacturing and secondary manufacturer start-up costs Source2026approximately $100 millionNew

What changed from last quarter

  • Guidance raised: The release title describes BRIUMVI revenue guidance as raised. The documents do not state the prior 2026 BRIUMVI figure. Source
  • New guidance: 2026 targets were issued in this release. The third-quarter release gave targets for 2025 only. Source
  • New: Collaboration with Christina Applegate announced to raise MS awareness through a Super Bowl LX commercial. The Next In MS platform was launched alongside it. Source

Full-year and quarterly results

  • Total revenue reached $192.6 million in Q4: Fourth-quarter total revenue was $192.6 million and full-year total revenue was $616.3 million, including BRIUMVI U.S. net revenue. Source
  • Product revenue grew on BRIUMVI sales: Product revenue, net was $189.1 million in Q4 and $606.9 million for the year, compared with $107.3 million and $313.7 million a year earlier. Source
  • License and milestone revenue lower: License, milestone, royalty and other revenue was $3.5 million in Q4 and $9.4 million for the year, against $0.8 million and $15.3 million a year earlier. The prior year included a $12.5 million milestone. Source

BRIUMVI sales and regional expansion

  • Q4 BRIUMVI U.S. sales reached $182.7 million: Q4 BRIUMVI U.S. net product revenue was $182.7 million, approximately 20% above Q3 2025. Source
  • Full-year U.S. sales up 92%: Full-year BRIUMVI U.S. net product revenue was $594.1 million, approximately 92% higher than the prior year. Source
  • Partner sales to Neuraxpharm disclosed: Sales to the ex-U.S. licensing partner Neuraxpharm were $12.8 million for 2025 and $3.7 million for 2024, included in product revenue, net. Source
  • BRIUMVI approved in six ex-U.S. markets: Through partner Neuraxpharm, BRIUMVI is now approved in the EU, UK, Switzerland, Australia, Kuwait and the UAE. Source

“As we enter 2026, we are focused on building on this foundation.”

Michael S. Weiss, the Company's Chairman and Chief Executive Officer

Costs, margins and net income

  • Net income includes non-recurring tax benefit: Net income was $23.0 million for Q4 and $447.2 million for the year, the annual figure including a non-recurring $339.8 million tax benefit from the Q3 2025 valuation allowance release. Source
  • R&D expense rose on manufacturing: R&D expense was $41.2 million in Q4 and $160.2 million for the year, against $23.9 million and $94.3 million. Manufacturing for subcutaneous work was the main driver. Source
  • SG&A rose on BRIUMVI commercial spend: SG&A expense was $62.7 million in Q4 and $232.0 million for the year, against $39.0 million and $154.3 million. Marketing, personnel and external costs were the cause. Source

Pipeline and clinical programs

  • Subcutaneous Phase 3 about 75% enrolled: Enrollment in the Phase 3 pivotal program for subcutaneous ublituximab reached approximately 75%. Source
  • ENHANCE pivotal enrollment completed: Enrollment is complete in the randomized Phase 3 pivotal ENHANCE program testing a consolidated Day 1 and Day 15 dose of IV BRIUMVI. Source
  • Azer-cel enrollment continues in progressive MS: Enrollment continued for progressive multiple sclerosis patients in the ongoing Phase 1 trial of azer-cel for autoimmune diseases. Source

“we believe we are well positioned to continue delivering value for patients, healthcare providers, and shareholders”

Michael S. Weiss, the Company's Chairman and Chief Executive Officer

Clinical data and publications

  • Six-year open-label extension data: Six-year open-label extension data for ULTIMATE I and II, presented at ECTRIMS 2025, showed 89.9% of relapsing MS patients free from 24-week confirmed disability progression. Source
  • Single 600 mg ENHANCE dose well tolerated: An open-label arm update of the ENHANCE trial showed that combining Day 1 and Day 15 infusions into one 600 mg dose was well tolerated. Source
  • Real-world ENABLE outcomes matched trials: The ENABLE real-world observational study of patients starting BRIUMVI showed clinical outcomes consistent with pivotal trials. Source
  • Five-year OLE paper in JAMA Neurology: A February 2026 JAMA Neurology article reported five-year open-label extension data for ULTIMATE I and II. Source

Capital, cash and share repurchases

  • Cash reached $199.5 million at year-end: Cash, cash equivalents and investment securities were $199.5 million at December 31, 2025, against $178.3 million at September 30, 2025 and $311,001 thousand at December 31, 2024. Source
  • Cash judged sufficient for current plan: Management anticipates that year-end cash plus projected BRIUMVI revenue will fund the business under the current operating plan. Source
  • New $100 million repurchase authorization: The board authorized up to an additional $100 million of TGTX share repurchases, first announced in the third-quarter 2025 release and restated here. Source

Coming up, as management said on 26 February 2026

  • ENHANCE pivotal topline data mid-2026: Topline pivotal data are expected for the ENHANCE trial combining Day 1 and Day 15 doses of IV BRIUMVI. Source
  • Azer-cel preliminary Phase 1 data: Preliminary Phase 1 data for azer-cel in progressive MS are expected to be presented. Source
  • Subcutaneous pivotal topline data year-end: Pivotal topline data for subcutaneous BRIUMVI are expected at year-end 2026 or first quarter 2027. Source
  • Registration-directed trial outside MS: A registration-directed trial for BRIUMVI in an indication outside of MS is set to start. Source
  • Exploratory autoimmune studies planned: Additional exploratory studies for BRIUMVI and azer-cel in autoimmune disease outside MS are planned to start. Source

Figures management reported

FigureReported
BRIUMVI U.S. net product revenue, Q4 2025 Source$182.7 million
BRIUMVI U.S. net product revenue, full year 2025 Source$594.1 million
Product revenue, net, full year 2025 Source$606.9 million
License, milestone, royalty and other revenue, full year 2025 Source$9.4 million
R&D expense, full year 2025 Source$160.2 million
SG&A expense, full year 2025 Source$232.0 million
Sales to ex-U.S. partner Neuraxpharm, full year 2025 Source$12.8 million
Subcutaneous ublituximab Phase 3 enrollment Sourceapproximately 75%

Earlier plans management reported on

  • Met: Management says the $100 million program announced earlier was completed in the third quarter of 2025. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.