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Myriad Genetics Inc.: Q2 FY2026 earnings call

What management said about Q2 FY2026, from the documents filed with the SEC on 30 July 2026: press release. Guidance figures: 2 lowered. The quarter’s numbers.

Key takeaways

  • Second quarter revenue fell 11%: Revenue was $190.7 million, down from $213.1 million. Volume fell 1% and average revenue per test fell 9%. Six-month revenue was $391.1 million, down 4%. Source
  • Full-year revenue range lowered: The company lowered its full-year 2026 revenue range to $770 million to $790 million from $860 million to $880 million, citing second quarter results and current business trends. Source
  • Adjusted EBITDA guidance suspended: The company suspended its previous full-year 2026 Adjusted EBITDA guidance, citing second quarter performance and strategic initiatives under way. Source
  • Precise MRD breast coverage request filed: In July 2026 the company asked the MolDX program, administered by Palmetto GBA, for a Local Coverage Determination for Precise MRD in breast cancer patients. Source
  • Prenatal revenue and volume declined: Prenatal Health revenue was $39.8 million, down 16% from $47.6 million, with volume down 9%. Management cited lower Prenatal volumes in its revised guidance. Source
  • Average revenue per test fell 9%: Average revenue per test fell 9%. The company said this partly reflects an $11.0 million reduction in revenue from changed estimates of cash collections on tests from prior periods. Source
  • Payer friction named top priority: Management called mitigating hereditary cancer revenue-per-test pressure from increased payer friction a top priority and said a comprehensive action plan is being executed. Source
  • Ascend efficiency initiative activated: The company activated an initiative called Ascend to increase organizational efficiency and scalability, supported by a leading professional services firm. Source

“Myriad Genetics' second quarter 2026 performance fell short of our expectations, as solid demand for our Hereditary Cancer and Mental Health tests was offset by volume challenges in Prenatal Health and increased payer friction.”

Sam Raha, President and CEO

Guidance

AreaPeriodFigureAgainst last quarter
Revenue SourceFY 2026$770 - $790Lowered from $860 - $880
Adjusted gross margin % SourceFY 202666% - 67%Lowered from 68% - 69%

What changed from last quarter

  • Guidance lowered: Full-year 2026 revenue range lowered to $770 million to $790 million from $860 million to $880 million. Source
  • Guidance lowered: Full-year 2026 adjusted gross margin range lowered to 66% to 67% from 68% to 69%. Source
  • Guidance withdrawn: Full-year 2026 Adjusted EBITDA guidance of $37 million to $49 million was suspended. Source
  • New: Ascend initiative launched to raise organizational efficiency, supported by a leading professional services firm. Source
  • New: Strategic review and product portfolio evaluation begun, with work on the review advanced during the quarter. Source
  • New: Prolaris + AI, the first AI-enabled prostate cancer test, launched with PATHOMIQ. The May release had expected the launch in the second quarter. Source
  • New: Precise MRD availability expanded to colorectal and renal cancers, in addition to the existing scope. Source
  • New: FirstGene Multiple Prenatal Screen launched in July 2026, covering four prenatal screens from one blood draw. Source

Results and guidance revision

  • Second quarter revenue fell 11%: Revenue was $190.7 million, down from $213.1 million. Volume fell 1% and average revenue per test fell 9%. Six-month revenue was $391.1 million, down 4%. Source
  • Full-year revenue range lowered: The company lowered its full-year 2026 revenue range to $770 million to $790 million from $860 million to $880 million, citing second quarter results and current business trends. Source
  • Adjusted EBITDA guidance suspended: The company suspended its previous full-year 2026 Adjusted EBITDA guidance, citing second quarter performance and strategic initiatives under way. Source
  • Net loss compared with 2025 impairment quarter: Net loss was $43.2 million, or $(0.46) per share, against $330.5 million in the prior-year quarter, which included $316.7 million of impairment charges. Source
  • Adjusted diluted loss per share: Adjusted diluted income (loss) per share was $(0.25) for the quarter, compared with $0.05 in the second quarter of 2025. Source

Cancer Care Continuum business

  • Cancer Care Continuum revenue down 11%: Revenue was $114.1 million, down 11% from $127.7 million, while test volume rose 6% to 95,000 tests in the quarter. Source
  • Hereditary testing revenue fell 13%: Hereditary cancer revenue fell 13% on lower reimbursement and unfavorable estimate changes tied mainly to first-quarter 2026 orders, partly offset by 8% volume growth. Source
  • Precise MRD expanded to new cancers: Precise MRD availability was broadened to patients undergoing treatment and surveillance for breast, colorectal and renal cancers. Source
  • Precise MRD breast coverage request filed: In July 2026 the company asked the MolDX program, administered by Palmetto GBA, for a Local Coverage Determination for Precise MRD in breast cancer patients. Source
  • Prolaris + AI launched with PATHOMIQ: The company launched Prolaris + AI, its first AI-enabled prostate cancer test, in partnership with PATHOMIQ. Source

“The combination of these developments and the first full quarter of increased costs associated with our expanded commercial team yielded pressure on our bottom line in the quarter.”

Sam Raha, President and CEO

Prenatal and Mental Health products

  • Prenatal revenue and volume declined: Prenatal Health revenue was $39.8 million, down 16% from $47.6 million, with volume down 9%. Management cited lower Prenatal volumes in its revised guidance. Source
  • FirstGene prenatal screen launched: The FirstGene Multiple Prenatal Screen launched in July 2026, with four prenatal screens available from one blood draw starting at eight weeks gestation. Source
  • GeneSight revenue down 3%: GeneSight revenue was $36.8 million, down 3%, with volume up 4%. Average revenue per test fell 6% on a write-off of aged receivables in the quarter. Source

Operating expense trends

  • Operating expenses fell on prior impairment: Operating expenses were $165.9 million, against $481.0 million a year earlier, when $316.7 million of impairment charges were recorded. Source
  • Adjusted operating expenses rose: Adjusted operating expenses rose $6.7 million to $150.5 million, which the company attributed to its multi-year investment in key strategic areas. Source
  • Operating loss of $38.9 million: Operating loss was $38.9 million, against $329.2 million a year earlier, when impairment charges were recorded. Source
  • Sales spending up, admin spending down: Sales and marketing expense rose to $83.1 million from $71.9 million, while general and administrative expense fell to $57.8 million from $66.8 million. Source

“While we are revising our full-year 2026 financial guidance due to lower Prenatal Health test volumes and more conservative assumptions regarding average revenue per test, we remain optimistic about our 2027 financial profile as we execute on multiple initiatives.”

Sam Raha, President and CEO

Margins and pricing pressure

  • Gross margin down 460 basis points: Gross margin was 66.6%, down 460 basis points year-over-year. Adjusted gross margin was 66.9%, against 71.5% in the second quarter of 2025. Source
  • Average revenue per test fell 9%: Average revenue per test fell 9%. The company said this partly reflects an $11.0 million reduction in revenue from changed estimates of cash collections on tests from prior periods. Source
  • Payer friction named top priority: Management called mitigating hereditary cancer revenue-per-test pressure from increased payer friction a top priority and said a comprehensive action plan is being executed. Source
  • Revenue cycle initiatives under way: The company is engaging payers and running revenue cycle initiatives that it expects to improve reimbursement predictability and performance. Source

Cash flow and balance sheet

  • Operating cash outflow and free cash flow: Cash used in operations was $8.3 million. Adjusted free cash flow was $(10.9) million after $3.2 million of capital expenditures and software capitalization. Source
  • Cash balance declined: Cash and cash equivalents were $115.2 million at June 30, 2026, down from $149.6 million at December 31, 2025. Source
  • Equity fell on accumulated deficit: Total stockholders' equity was $303.9 million at June 30, 2026, down from $368.0 million. The accumulated deficit reached $(1,200.0) million. Source
  • Shares outstanding increased: Common shares outstanding rose to 95.6 million at June 30, 2026, from 93.5 million at December 31, 2025. Source

Strategy and portfolio review

  • Ascend efficiency initiative activated: The company activated an initiative called Ascend to increase organizational efficiency and scalability, supported by a leading professional services firm. Source
  • Strategic review aims at growth: The strategic review is intended to identify initiatives to increase growth, profitability and liquidity. Work on it advanced during the quarter. Source
  • Product portfolio under evaluation: Management is doing a rigorous evaluation of the product portfolio to determine the allocation of capital and the enhancement of shareholder value. Source
  • Strategic realignment costs rose: Strategic realignment costs, covering severance and consulting fees, were $2.3 million in the quarter, against $0.1 million a year earlier. Source

Clinical data and publications

  • MONITOR-Breast study published: Results from the prospective 949-sample, multi-center MONITOR-Breast study were published in Future Oncology. The company believes they support Precise MRD clinical validity in breast cancer. Source
  • Interim MRD study data at ASCO: Several ASCO presentations reported interim outcomes from the MONSTAR-SCREEN-3 study, led by Dr. Takayuki Yoshino, on the prognostic power of the ultrasensitive MRD assay. Source
  • Prolaris meta-analysis published: Newly published individual-patient-data meta-analysis of Prolaris covered 14 studies and more than 8,000 patients, according to the company's July 2026 announcement. Source

Coming up, as management said on 30 July 2026

  • Precise MRD breast coverage decision pending: The company submitted Precise MRD for breast cancer to MolDX for a coverage determination. The release gives no date for a decision. Source
  • CONNECTOR study may support launches: If the CONNECTOR study succeeds, the company expects it to support future commercial launch activities and expand prenatal testing capabilities. Source

Figures management reported

FigureReported
Cancer Care Continuum product revenue Source$114.1 million
Prenatal Health product revenue Source$39.8 million
Mental Health (GeneSight) product revenue Source$36.8 million
Research and development expense Source$25.0 million (Q2 2026); $25.6 million (Q2 2025)
Precise MRD breast coverage submission Sourcesubmitted to MolDX, July 2026
Product launches SourceProlaris + AI (Q2 2026); FirstGene Multiple Prenatal Screen (July 2026)
Clinical study publication SourceMONITOR-Breast, 949 samples

Risks management discussed

  • External: Payer friction is putting pressure on average revenue per test for hereditary cancer testing, which management named a top priority. Source
  • Demand: Prenatal test volumes fell, and the revised 2026 plan assumes lower average revenue per test. Source
  • Operational: The first full quarter of costs for the expanded commercial team added pressure to the bottom line. Source
  • Financial: Cash used in operations continued in the quarter, and cash fell to $115.2 million by June 30, 2026. Source
  • Financial: Interest expense rose to $4.1 million from $1.5 million, with long-term debt at $120.7 million on June 30, 2026. Source
  • Regulatory: Medicare coverage for Precise MRD in breast cancer has not been determined; the request was submitted in July 2026. Source

Earlier plans management reported on

  • On track: The May release said the company remained on track with its other planned 2026 launches.
  • Met: The May release expected the Prolaris + AI launch in the second quarter. The July release reports the launch. Source
  • Not stated: The May release expected improved performance in the rest of 2026. The July release lowered full-year revenue guidance.
  • Not stated: The May guidance table expected second-half 2026 revenue to exceed first-half revenue. The July release does not repeat this comment.

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.