Lexicon Pharmaceuticals, Inc. 13F holders
150 funds reported a position in Lexicon Pharmaceuticals, Inc. in their 13F for the quarter ended 30 June 2026, together 364.6 million shares worth $875.1 million. Against the quarter before, 43 opened a position, 37 added, 36 trimmed and 30 sold out; together they bought a net 41.2 million shares. The largest holders: Artal Group S.A., FMR LLC and Siren, L.L.C.
Funds holding150+14 on Q1 2026
Shares they held364.6Mworth $875.1 million
Net bought on the quarter41.2M sharesabout $99.0 million at the funds' values
Funds buying to selling80 to 66opened or added, to cut or sold
Opened 43Added 37Held 33Trimmed 36Sold out 30
What each fund did in LXRX against its 13F for the quarter before; a change under 0.1% of a holding counts as held
Funds reporting a position in LXRX in their 13F, each quarter; hover a bar for the shares they held
Filed so far for the quarter to 30 September 2026
3,241 funds have filed their 13F for the quarter so far; the rest are due by 16 November 2026. Of those, 24 reported a position in Lexicon Pharmaceuticals, Inc.: 3 opened one, 4 added, 5 trimmed and 1 sold out, a net 206,762 shares bought.
| Fund | Change in shares | Shares now | Status | Filing |
|---|---|---|---|---|
| Profund Advisors LLC | +291,893 | 340,479 | added | 13F |
| State of Wyoming | -104,078 | 15,012 | trimmed | 13F |
| Virginia Retirement Systems ET Al | +35,300 | 35,300 | new | 13F |
| Caitong International Asset Management Co., Ltd | +25,169 | 25,326 | added | 13F |
| SBI Securities Co., Ltd. | -14,997 | 4,208 | trimmed | 13F |
| Sterling Capital Management LLC | +6,617 | 7,491 | added | 13F |
| ProShare Advisors LLC | -4,079 | 28,509 | trimmed | 13F |
| Nisa Investment Advisors, LLC | +1,054 | 3,646 | added | 13F |
| Parkside Financial Bank & Trust | +505 | 505 | new | 13F |
| Pinnacle Associates Ltd | -400 | 28,615 | trimmed | 13F |
| Wealth Enhancement Advisory Services, LLC | -374 | 11,765 | trimmed | 13F |
| Gamma Investing LLC | +152 | 152 | new | 13F |
| Leonteq Securities AG | -30,000 | 0 | sold out | 13F |
The largest moves in the name among the funds that have filed, against each fund's previous 13F.
The well-known funds
Of the 44 funds followed here, 7 reported a position in Lexicon Pharmaceuticals, Inc. in a 13F for the quarter ended 30 June 2026. The largest: FMR LLC, 51.8 million shares worth $124.3 million, 0.0% of its reported book. In the quarter, 4 funds added or opened a position and 3 trimmed or sold out; together they bought a net 5.9 million shares, about $14.2 million at the funds' own value per share on 30 June 2026. A change under 0.1% of a holding counts as held.
| Fund | Shares | Value | Of its book | Change on the quarter | Status | Quarter ended | Filing |
|---|---|---|---|---|---|---|---|
| FMR LLC | 51,782,045 | $124.3 million | 0.0% | +6,725,707 | added | 30 June 2026 | 13F |
| Point72 Asset Management | 8,251,325 | $19.8 million | 0.0% | +436,719 | added | 30 June 2026 | 13F |
| Geode Capital Management | 6,244,372 | $15.0 million | 0.0% | +3,075,261 | added | 30 June 2026 | 13F |
| Citadel Advisors | 1,601,182 | $3.8 million | 0.0% | +506,281 | added | 30 June 2026 | 13F |
| Millennium Management | 1,134,229 | $2.7 million | 0.0% | -3,810,502 | trimmed | 30 June 2026 | 13F |
| Renaissance Technologies | 1,127,000 | $2.7 million | 0.0% | -473,500 | trimmed | 30 June 2026 | 13F |
| Two Sigma Investments | 643,444 | $1.5 million | 0.0% | -556,188 | trimmed | 30 June 2026 | 13F |
Value is what the fund reported.
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Change is shares against the fund's previous 13F; a fund with one filing read shows no change. 13Fs cover long US positions of managers above $100 million and are filed up to 45 days after the quarter.The largest holders
| Fund | Shares | Share of all | Value | Of its book | Change in shares | Filing |
|---|---|---|---|---|---|---|
| Artal Group S.A. | 175,156,062 | 48.04% | $420.4 million | 45.15% | +20,421,735 | 13F |
| FMR LLC | 51,782,045 | 14.20% | $124.3 million | 0.01% | +6,725,707 | 13F |
| Siren, L.L.C. | 44,303,518 | 12.15% | $106.3 million | 2.16% | no change | 13F |
| Sessa Capital IM, L.P. | 18,960,836 | 5.20% | $45.5 million | 0.79% | +1,047,875 | 13F |
| BlackRock, Inc. | 17,348,741 | 4.76% | $41.6 million | 0.00% | +14,026,522 | 13F |
| Vanguard Capital Management LLC | 9,901,208 | 2.72% | $23.8 million | 0.00% | +382,041 | 13F |
| Point72 Asset Management, L.P. | 8,251,325 | 2.26% | $19.8 million | 0.03% | +436,719 | 13F |
| Geode Capital Management, LLC | 6,244,372 | 1.71% | $15.0 million | 0.00% | +3,075,261 | 13F |
| State Street Corp. | 4,917,769 | 1.35% | $11.8 million | 0.00% | +3,953,731 | 13F |
| Vanguard Portfolio Management LLC | 2,357,749 | 0.65% | $5.7 million | 0.00% | +1,811,149 | 13F |
| Northern Trust Corp. | 1,968,619 | 0.54% | $4.7 million | 0.00% | +1,473,953 | 13F |
| Charles Schwab Investment Management Inc. | 1,956,775 | 0.54% | $4.7 million | 0.00% | +645,477 | 13F |
| Vanguard Fiduciary Trust Co. | 1,634,571 | 0.45% | $3.9 million | 0.00% | +302,287 | 13F |
| Citadel Advisors LLC | 1,601,182 | 0.44% | $3.8 million | 0.00% | +506,281 | 13F |
| Ishara Investments LP | 1,271,000 | 0.35% | $3.1 million | 2.24% | +369,000 | 13F |
| Millennium Management LLC | 1,134,229 | 0.31% | $2.7 million | 0.00% | -3,810,502 | 13F |
| Renaissance Technologies LLC | 1,127,000 | 0.31% | $2.7 million | 0.00% | -473,500 | 13F |
| Mackenzie Financial Corp. | 963,354 | 0.26% | $2.3 million | 0.00% | +190,677 | 13F |
| ADAR1 Capital Management, LLC | 750,000 | 0.21% | $1.8 million | 0.09% | no change | 13F |
| Susquehanna International Group, LLP | 696,776 | 0.19% | $1.7 million | 0.00% | -1,424,388 | 13F |
| Acadian Asset Management LLC | 696,617 | 0.19% | $1.7 million | 0.00% | +251,329 | 13F |
| UBS Group AG | 684,713 | 0.19% | $1.6 million | 0.00% | -1,798,469 | 13F |
| Two Sigma Investments, LP | 643,444 | 0.18% | $1.5 million | 0.00% | -556,188 | 13F |
| Nuveen, LLC | 586,664 | 0.16% | $1.4 million | 0.00% | new | 13F |
| Bank of New York Mellon Corp | 568,706 | 0.16% | $1.4 million | 0.00% | +541,247 | 13F |
| Invesco Ltd. | 508,071 | 0.14% | $1.2 million | 0.00% | -4,355 | 13F |
| Goldman Sachs Group Inc. | 485,546 | 0.13% | $1.2 million | 0.00% | -584,971 | 13F |
| Compagnie Lombard Odier SCmA | 480,000 | 0.13% | $1.2 million | 0.01% | -30,000 | 13F |
| Bank of America Corp. | 421,299 | 0.12% | $1.0 million | 0.00% | -104,804 | 13F |
| Gsa Capital Partners LLP | 397,219 | 0.11% | $953,000 | 0.06% | -532,870 | 13F |
| Barclays PLC | 387,483 | 0.11% | $929,960 | 0.00% | +281,996 | 13F |
| XTX Topco Ltd | 357,877 | 0.10% | $858,905 | 0.01% | +43,263 | 13F |
| Janney Montgomery Scott LLC | 295,548 | 0.08% | $709,000 | 0.00% | new | 13F |
| Canada Pension Plan Investment Board | 257,900 | 0.07% | $618,960 | 0.00% | new | 13F |
| Rhumbline Advisers | 256,885 | 0.07% | $616,523 | 0.00% | +256,885 | 13F |
| Deutsche Bank AG | 247,528 | 0.07% | $594,068 | 0.00% | new | 13F |
| Wells Fargo & Company | 230,470 | 0.06% | $553,128 | 0.00% | +222,710 | 13F |
| Price T Rowe Associates Inc. | 204,391 | 0.06% | $491,000 | 0.00% | new | 13F |
| Wellington Management Group LLP | 179,700 | 0.05% | $431,280 | 0.00% | new | 13F |
| Citigroup Inc. | 175,205 | 0.05% | $420,492 | 0.00% | +8,807 | 13F |
| Group One Trading LLC | 175,013 | 0.05% | $420,031 | 0.01% | -9,993 | 13F |
| Virtus Investment Advisers, LLC | 170,415 | 0.05% | $408,996 | 0.10% | new | 13F |
| Headlands Technologies LLC | 167,198 | 0.05% | $401,275 | 0.04% | -24,124 | 13F |
| Ikarian Capital, LLC | 164,674 | 0.05% | $395,218 | 0.07% | no change | 13F |
| Quarry LP | 156,186 | 0.04% | $374,846 | 0.06% | +46,186 | 13F |
| MetLife Investment Management, LLC | 146,410 | 0.04% | $351,384 | 0.00% | new | 13F |
| Morgan Stanley | 132,902 | 0.04% | $318,964 | 0.00% | -86,960 | 13F |
| Panagora Asset Management Inc. | 132,042 | 0.04% | $316,901 | 0.00% | new | 13F |
| JPMorgan Chase & Co. | 109,839 | 0.03% | $289,975 | 0.00% | new | 13F |
| State of Wyoming | 119,090 | 0.03% | $285,816 | 0.03% | +108,311 | 13F |
The 50 largest of the 150 funds that reported a position in LXRX in their 13F for the quarter ended 30 June 2026, by the value each reported.
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Share of all is the fund's part of all the shares the funds reported. Change is shares against the fund's 13F for the quarter before. A 13F lists a manager's long positions in US-listed shares at the quarter's end. What is a 13F?Options the funds reported on LXRX
| Fund | Option | Shares under the options | Value of those shares | Quarter ended | Filing |
|---|---|---|---|---|---|
| Citadel Advisors | Calls | 369,300 | $886,320 | 30 June 2026 | 13F |
| Citadel Advisors | Puts | 17,900 | $42,960 | 30 June 2026 | 13F |
A 13F lists calls and puts by the shares they cover and what those shares were worth at the quarter's end, not what the options cost.
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They are not counted in the holdings above. A put gains when the stock falls, a call when it rises, and a fund may hold either to hedge.Schedule 13D and 13G filed on the name, last twelve months
| Filed | Schedule | Who | Holding | Of the class | Event date | Rule or purpose | Filing |
|---|---|---|---|---|---|---|---|
| 6 August 2026 | 13G/A | FMR LLC and 3 others | 51.8 million | 11.7% | 30 June 2026 | passive, institutional (13d-1(b)) | EDGAR |
| 8 May 2026 | 13D/A | Invus, L.P. and 17 others | 175.2 million | 39.4% | 30 April 2026 | Item 4 of the Statement is hereby amended and supplemented as follows: As previously disclosed in Amendment No. 25, on February 2, 2026, Artal Participations S.a.r.l. acquired 367,145.12 shares of Preferred Stock, and on February 17, 2026 A | EDGAR |
| 2 February 2026 | 13D/A | Invus, L.P. and 17 others | 154.7 million | 36.2% | 29 January 2026 | Item 4 of the Statement is hereby amended and supplemented as follows: The information set forth in Items 3, 5 and 6 of the Statement is incorporated herein by reference On January 29, 2026, the Issuer announced its intention to conduct an | EDGAR |
A Schedule 13D is filed by anyone who crosses 5% of a class with intent to influence; a 13G by a passive holder.
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Amendments (/A) report a change, including an exit to zero. Holding and percentage are as the filer stated them on the cover page; the purpose is the filer's own words, cut short. 13D and 13GFails to deliver
| Settlement date | Shares failed | Price | File |
|---|---|---|---|
| 30 September 2026 | 3,304 | $1.88 | SEC |
| 24 September 2026 | 12,983 | $2.06 | SEC |
| 8 September 2026 | 21,722 | $2.24 | SEC |
| 1 September 2026 | 114 | $2.25 | SEC |
| 31 August 2026 | 95,876 | $2.29 | SEC |
| 25 August 2026 | 10,342 | $2.32 | SEC |
| 24 August 2026 | 124,382 | $2.30 | SEC |
| 21 August 2026 | 3,121 | $2.18 | SEC |
| 18 August 2026 | 17 | $2.34 | SEC |
Shares that failed to deliver at settlement, per day, from the SEC's half-month files, which arrive about two weeks after the period.