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Lantheus Holdings (LNTH) FY2025 results: revenue $1.5 billion, up 0.5% on the year

Lantheus Holdings, Inc. (LNTH) reported revenue of $1.5 billion for fiscal 2025, the year ended 31 December 2025, up 0.5% on the year before. Net income was $234 million, down 25.2%, and diluted earnings per share $3.41. The figures are the company's own, from the 10-K it filed with the SEC on 26 February 2026.

Revenue
$1.5 billion
+0.5% on the year
FY2018FY2025
Operating margin
20.2%
29.8% a year earlier
FY2018FY2025
Net income
$234 million
-25.2% on the year
FY2018FY2025
Diluted EPS
$3.41
-21.8% on the year
FY2018FY2025

this yearthe year beforeHover a bar for its figure.

The year in brief

What management said about the year

Guidance figures: 2 new.

  • Revenue rose 4.0% in quarter: Worldwide revenue was $406.8 million for the fourth quarter, up from $391.1 million. Full year revenue was $1.54 billion, up 0.5% from $1.53 billion.
  • Adjusted EPS rose; GAAP EPS turned positive: Adjusted diluted EPS was $1.67 against $1.59, and GAAP diluted EPS was $0.82 against a loss of $0.17. Full year adjusted diluted EPS was $6.08 against $6.76.
  • PYLARIFY sales fell 9.7%: PYLARIFY sales were $240.2 million in the quarter, down from $265.9 million. Full year PYLARIFY sales were $989.1 million, down 6.5%.
  • Neuraceq reached $31.0 million: Neuraceq sales were $31.0 million in the quarter and $51.4 million for the year. Management described Neuraceq as the second largest commercially approved amyloid PET agent used in the U.S.
  • Operating income fell 32.2%: Operating income was $77.2 million, down 32.2%. Adjusted operating income was $138.9 million, down 8.5% from $151.8 million.
Read the Q4 FY2025 earnings call summary

From this 10-K

Lantheus makes radiopharmaceuticals and other imaging agents that help doctors find, treat and monitor disease, especially prostate cancer, heart disease and Alzheimer's disease. It groups its products into three categories: Radiopharmaceutical Oncology, Precision Diagnostics, and Strategic Partnerships and Other Revenue. It is headquartered in Massachusetts, with offices in New Jersey, Canada, Germany, Switzerland, Sweden and the United Kingdom.

Lantheus Holdings, Inc., the 10-K for 2025

Lantheus makes radiopharmaceuticals and other imaging agents that help doctors find, treat and monitor disease, especially prostate cancer, heart disease and Alzheimer's disease. It groups its products into three categories: Radiopharmaceutical Oncology, Precision Diagnostics, and Strategic Partnerships and Other Revenue. It is headquartered in Massachusetts, with offices in New Jersey, Canada, Germany, Switzerland, Sweden and the United Kingdom.

Products

PYLARIFY is an F-18-labeled PET imaging agent that targets PSMA, approved by the FDA in May 2021, used to image prostate cancer in men with suspected metastasis or suspected recurrence. DEFINITY is an injectable ultrasound enhancing agent made of lipid microbubbles, used in echocardiography exams to improve images of the heart's left ventricle. Neuraceq, an F-18 labeled PET imaging agent approved by the FDA in 2014, binds to beta-amyloid plaques in the brain and is used for patients being evaluated for Alzheimer's disease and other causes of cognitive decline. Its software products include aBSI, which measures the spread of prostate cancer on bone scans, and PYLARIFY AI, for analyzing PSMA PET/CT images. It also earns royalties from partners, such as on flurpiridaz, a heart imaging agent licensed to GE Healthcare and approved by the FDA in 2024 as Flyrcado.

Customers

Its products are used by cardiologists, neurologists, nuclear medicine physicians, oncologists, radiologists, urologists and other clinicians. In the United States it sells mainly to hospitals, independent imaging centers and government facilities. Outside the United States it sells through its own and third-party distribution in Europe, Canada, Australia, Asia-Pacific and Central and South America, and licenses some products to others.

Recent transactions

On January 1, 2026, it sold its SPECT business, including TechneLite, NEUROLITE, Xenon Xe-133 Gas and Cardiolite and part of its North Billerica, Massachusetts campus, to SHINE Technologies. On July 21, 2025, it bought Life Molecular Imaging, based in Berlin, which brought Neuraceq, and renamed it Lantheus Biosciences in February 2026. On April 1, 2025, it bought Evergreen Theragnostics, a clinical-stage radiopharmaceutical company that also provides contract development and manufacturing. It also holds rights to develop and commercialize PNT2003, a lutetium-177 therapy for neuroendocrine tumors, licensed from POINT Biopharma, now owned by Lilly.

People

It had 1,193 employees at December 31, 2025, 1,056 in the United States and 137 elsewhere, none covered by a collective bargaining agreement. Mary Anne Heino, chair of the board, became chief executive on January 1, 2026, after Brian Markison retired.

From Lantheus Holdings' annual report on Form 10-K for the year ended 31 December 2025. The filing

Written from the 10-K filed 26 February 2026: read the full 10-K.

The four quarters: Q1 FY2025 · Q2 FY2025 · Q3 FY2025 · Q4 FY2025

Income statement (profit and loss)

$ millionFY2025FY2024FY2023On the yearLast 8 years
Revenue1,5421,5341,296+0.5%
Cost of revenue600546587+9.9%
Gross profit942988710-4.7%
Gross margin61.1%64.4%54.7%
Research and development17716877.7+5.5%
Operating income311457365-32.0%
Operating margin20.2%29.8%28.1%
Interest expense19.719.720.0+0.4%
Pre-tax income314431411-27.2%
Income tax80.211984.3-32.3%
Effective tax rate25.6%27.5%20.5%
Net income234312327-25.2%
Net margin15.2%20.4%25.2%
Diluted EPS$3.41$4.36$4.65-21.8%
$ million except per share.
Read moreFree cash flow is operating cash flow less capital expenditure; the effective tax rate is income tax over pre-tax income; margins are the line over revenue. Gross profit is revenue less cost of revenue, and operating income is revenue less the company's own total costs, where the statement does not print those lines. Those four are arithmetic on the filed numbers; everything else is as filed. Money is in $ million as the company files it, or in $ billion by the switch above the tables; per share figures and share counts are as they are.

Cash flow

$ millionFY2025FY2024FY2023On the yearLast 8 years
Operating cash flow390545305-28.4%
Capital expenditure36.151.645.3-30.1%
Free cash flow354493260-28.2%
Free cash flow margin23.0%32.1%20.0%
Cash from investing-627-2265.9
Cash from financing-317-119-13.1
Depreciation and amortisation70.164.660.0+8.5%
Share-based compensation85.676.450.5+12.0%
Buybacks3001000.0+200.0%
Diluted shares, weighted68m72m70m-4.5%
Shares outstanding at period end65m71m70m-8.9%

Balance sheet

$ millionFY2025FY2024FY2023On the yearLast 8 years
Shareholders' equity1,0901,088816+0.2%
Debt569565562+0.6%
Operating lease liabilities50.053.254.5-6.0%
Finance lease liabilities0.50.70.6-23.8%
Other liabilities518273219+89.8%
Total liabilities and equity2,2271,9801,651+12.5%
Fixed assets164177147-7.4%
Goodwill24061.261.2+291.4%
Intangible assets723162152+346.8%
Cash and equivalents359913714-60.7%
Receivables359321284+11.6%
Inventory64.768.064.0-4.9%
Other assets319278229+14.5%
Total assets2,2271,9801,651+12.5%

10-K for the year ended 31 December 2025, filed 26 February 2026: the filing.