Kymera Therapeutics, Inc. insider trading
In twelve months insiders at Kymera Therapeutics bought $172M and sold $467M on the open market; 221 of the 263 sales were under plans set months before.
New to this? How to read this page
- Insiders are the people who run the company: officers, directors and owners of 10% or more. They must report a trade on Form 4 within two business days.
- A purchase on the open market is the strongest sign: the insider spent their own money.
- A sale under a trading plan (Rule 10b5-1) says little: its dates were fixed months before. Sales outside a plan say more, but insiders sell for many reasons, such as taxes or a house.
- Grants, option exercises and shares held back for tax are left out.
- What is a Form 4? · Form 4 codes
What kind of trades
2 purchases worth $172M against 263 sales worth $467M; 221 of the sales were under plans set months before.
Every Form 4 line of the last twelve months, counted by kind. The grades come from the filing itself: whether the insider paid cash, whether a plan set the date, whether pay was taken in stock by choice.
Insider trades on the share price
last twelve months58 marks over twelve months, each in its grade: solid for the stronger signs, hollow or grey for the ones that say little.
The blue line is the daily close over twelve months. Each mark is one insider's trades on one day, on that day's price, sized by dollar value. Solid marks are the stronger signs; hollow and grey marks say little. Hover or tap a mark for who, how much and why.
Trades worth a closer look
A purchase stands out when two or more of these hold: a senior insider, several insiders buying within 90 days, a fall of 10% or more in the three months before, or over $1 million. A sale outside a plan is judged the same way. These are the Feed's rules.
Who traded
dollars, twelve months12 insiders traded. The most: Booth Bruce, sale outside a plan $21.7M; sale under a plan $196M.
One row per insider, sold to the left and bought to the right, split by grade: the paler part of a bar is the part that says little.
How it compares
every company on the siteOpen-market sales, twelve months
Open-market purchases, twelve months
The bar ranks every company on the site from the lowest on the left to the highest on the right, in three equal thirds; the small figures under it are the values where each third starts, and the black tick is the middle company. The orange dot is this company; the grey ticks are the other companies in its industry (hover or tap for names). A hatched block is companies tied at none.
Every Form 4 line
| Traded | Insider | Role | Type | Shares | Price | Value | Filing |
|---|---|---|---|---|---|---|---|
| 1 October 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 1 October 2026 | 3,525 | $111.44 | $392,826 | Form 4 |
| 1 October 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 1 October 2026 | 5,506 | $112.42 | $618,985 | Form 4 |
| 1 October 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 1 October 2026 | 4,876 | $113.24 | $552,158 | Form 4 |
| 1 October 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 1 October 2026 | 7,601 | $114.43 | $869,782 | Form 4 |
| 1 October 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 1 October 2026 | 8,230 | $115.40 | $949,742 | Form 4 |
| 1 October 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 1 October 2026 | 262 | $116.12 | $30,423 | Form 4 |
| 4 September 2026 | Adams Brian | Chief Legal Officer | Saleafter a 58% rise over three months · 8% below its one-year high · Form 144 notice 4 September 2026 | 1,209 | $115.55 | $139,700 | Form 4 |
| 4 September 2026 | Adams Brian | Chief Legal Officer | Saleafter a 58% rise over three months · 8% below its one-year high · Form 144 notice 4 September 2026 | 3,025 | $116.81 | $353,350 | Form 4 |
| 4 September 2026 | Adams Brian | Chief Legal Officer | Saleafter a 58% rise over three months · 8% below its one-year high · Form 144 notice 4 September 2026 | 2,137 | $117.57 | $251,247 | Form 4 |
| 7 July 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 7 July 2026 | 50,000 | $119.00 | $6.0 million | Form 4 |
| 1 July 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 1 July 2026 | 3,389 | $114.29 | $387,329 | Form 4 |
| 1 July 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 2 July 2026 | 1,883 | $112.80 | $212,411 | Form 4 |
| 1 July 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 2 July 2026 | 6,626 | $113.98 | $755,204 | Form 4 |
| 1 July 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 2 July 2026 | 24,105 | $114.96 | $2.8 million | Form 4 |
| 1 July 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 2 July 2026 | 44,050 | $115.69 | $5.1 million | Form 4 |
| 1 July 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 2 July 2026 | 3,336 | $116.56 | $388,841 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 1,500 | $110.54 | $165,810 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 1,700 | $111.57 | $189,664 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 1,100 | $112.79 | $124,067 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 4,110 | $114.19 | $469,311 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 51,375 | $114.77 | $5.9 million | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 7,971 | $115.82 | $923,178 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 6,153 | $116.99 | $719,862 | Form 4 |
| 30 June 2026 | Jacobs Bruce N. | Chief Financial Officer | Saletrading plan set in advance · Form 144 notice 30 June 2026 | 3,200 | $117.70 | $376,649 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 10,658 | $108.28 | $1.2 million | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 7,833 | $109.75 | $859,672 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 7,602 | $110.67 | $841,313 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 907 | $111.20 | $100,858 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,688 | $108.28 | $182,777 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,239 | $109.75 | $135,980 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,199 | $110.67 | $132,693 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 157 | $111.20 | $17,458 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 5,471 | $105.78 | $578,722 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 14,613 | $106.63 | $1.6 million | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 19,093 | $107.76 | $2.1 million | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 848 | $105.78 | $89,701 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,318 | $106.63 | $247,168 | Form 4 |
| 29 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,024 | $107.76 | $325,866 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 28,296 | $107.57 | $3.0 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 231,007 | $108.14 | $25.0 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 32,624 | $109.79 | $3.6 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 11,277 | $110.49 | $1.2 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 10,366 | $111.51 | $1.2 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 555 | $112.49 | $62,432 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 14,913 | $113.97 | $1.7 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 27,951 | $114.94 | $3.2 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 6,821 | $115.69 | $789,121 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 12,181 | $117.09 | $1.4 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 22,046 | $117.85 | $2.6 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 12,390 | $118.66 | $1.5 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,958 | $107.57 | $425,762 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 32,402 | $108.14 | $3.5 million | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 4,562 | $109.79 | $500,862 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,579 | $110.49 | $174,464 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,442 | $111.51 | $160,797 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 78 | $112.49 | $8,774 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,083 | $113.97 | $237,400 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,896 | $114.94 | $447,806 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 952 | $115.69 | $110,137 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,701 | $117.09 | $199,170 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,069 | $117.85 | $361,682 | Form 4 |
| 26 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,729 | $118.66 | $205,163 | Form 4 |
| 26 June 2026 | Bvf Partners L P/Il | Director | Saleafter a 38% rise over three months · 7% below its one-year high · Form 144 notice 26 June 2026 | 837,914 | $106.50 | $89.2 million | Form 4 |
| 26 June 2026 | Bvf Partners L P/Il | Director | Saleafter a 38% rise over three months · 7% below its one-year high · Form 144 notice 26 June 2026 | 627,597 | $106.50 | $66.8 million | Form 4 |
| 26 June 2026 | Bvf Partners L P/Il | Director | Saleafter a 38% rise over three months · 7% below its one-year high · Form 144 notice 26 June 2026 | 113,289 | $106.50 | $12.1 million | Form 4 |
| 26 June 2026 | Bvf Partners L P/Il, see footnote | Director | Saleafter a 38% rise over three months · 7% below its one-year high · Form 144 notice 26 June 2026 | 51,858 | $106.50 | $5.5 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 37,179 | $119.71 | $4.5 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 112,299 | $120.66 | $13.5 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 40,774 | $121.38 | $4.9 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 4,977 | $122.67 | $610,529 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 10,860 | $123.62 | $1.3 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 11,711 | $124.61 | $1.5 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,716 | $125.82 | $467,547 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,609 | $126.71 | $203,876 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 25,075 | $127.37 | $3.2 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,197 | $128.69 | $282,732 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 337 | $129.61 | $43,679 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 5,144 | $119.71 | $615,788 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 15,660 | $120.66 | $1.9 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 5,689 | $121.38 | $690,531 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 698 | $122.67 | $85,624 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,517 | $123.62 | $187,532 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,639 | $124.61 | $204,236 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 522 | $125.82 | $65,678 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 223 | $126.71 | $28,256 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,507 | $127.37 | $446,687 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 305 | $128.69 | $39,250 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 46 | $129.61 | $5,962 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 9,994 | $107.30 | $1.1 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 159 | $108.02 | $17,175 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 14,351 | $108.83 | $1.6 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,915 | $110.30 | $211,224 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 614 | $110.79 | $68,025 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 719 | $111.89 | $80,449 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 10,215 | $113.70 | $1.2 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 9,229 | $114.65 | $1.1 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 58,205 | $115.57 | $6.7 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 81,500 | $116.53 | $9.5 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 24,268 | $117.50 | $2.9 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 19,089 | $118.60 | $2.3 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,399 | $107.30 | $150,113 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 23 | $108.02 | $2,484 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,011 | $108.83 | $218,857 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 265 | $110.30 | $29,230 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 86 | $110.79 | $9,528 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 100 | $111.89 | $11,189 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,437 | $113.70 | $163,387 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,289 | $114.65 | $147,784 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 8,389 | $115.57 | $969,517 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 11,375 | $116.53 | $1.3 million | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,359 | $117.50 | $394,682 | Form 4 |
| 25 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,646 | $118.60 | $313,816 | Form 4 |
| 25 June 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 25 June 2026 | 2,500 | $109.00 | $272,500 | Form 4 |
| 25 June 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 25 June 2026 | 2,500 | $119.00 | $297,500 | Form 4 |
| 24 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 103,688 | $100.42 | $10.4 million | Form 4 |
| 24 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 14,513 | $100.42 | $1.5 million | Form 4 |
| 24 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 14,490 | $101.14 | $1.5 million | Form 4 |
| 24 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,029 | $101.14 | $205,213 | Form 4 |
| 23 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,235 | $99.98 | $123,475 | Form 4 |
| 23 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 173 | $99.98 | $17,297 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 18,313 | $103.42 | $1.9 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 9,584 | $104.38 | $1.0 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,560 | $103.42 | $264,755 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,341 | $104.38 | $139,974 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 14,921 | $92.14 | $1.4 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,035 | $94.48 | $192,267 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 11,783 | $95.12 | $1.1 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 20,903 | $96.24 | $2.0 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 16,084 | $97.68 | $1.6 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 25,976 | $98.58 | $2.6 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 52,442 | $99.57 | $5.2 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 56,348 | $100.17 | $5.6 million | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 6,597 | $101.61 | $670,321 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 8,990 | $102.48 | $921,295 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,179 | $92.14 | $200,773 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 286 | $94.48 | $27,021 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,648 | $95.12 | $156,758 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,919 | $96.24 | $280,925 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 2,247 | $97.68 | $219,487 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 3,603 | $98.58 | $355,184 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 7,319 | $99.57 | $728,753 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 7,879 | $100.17 | $789,239 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 918 | $101.61 | $93,278 | Form 4 |
| 22 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 1,253 | $102.48 | $128,407 | Form 4 |
| 22 June 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 22 June 2026 | 2,500 | $99.00 | $247,500 | Form 4 |
| 18 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 62,897 | $90.48 | $5.7 million | Form 4 |
| 18 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 32,359 | $91.85 | $3.0 million | Form 4 |
| 18 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 5,672 | $92.16 | $522,732 | Form 4 |
| 18 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 8,809 | $90.48 | $797,038 | Form 4 |
| 18 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 4,526 | $91.85 | $415,713 | Form 4 |
| 18 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 793 | $92.16 | $73,083 | Form 4 |
| 17 June 2026 | Booth Bruce | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 11,741 | $89.98 | $1.1 million | Form 4 |
| 17 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 92,169 | $90.38 | $8.3 million | Form 4 |
| 17 June 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 17 June 2026 | 12,902 | $90.38 | $1.2 million | Form 4 |
| 27 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 3,679 | $81.50 | $299,850 | Form 4 |
| 27 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 600 | $82.08 | $49,246 | Form 4 |
| 26 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 3,730 | $78.36 | $292,271 | Form 4 |
| 26 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 324 | $79.17 | $25,651 | Form 4 |
| 26 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 3,800 | $79.39 | $301,691 | Form 4 |
| 26 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 4,500 | $80.02 | $360,111 | Form 4 |
| 26 May 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 26 May 2026 | 551 | $80.71 | $44,470 | Form 4 |
| 11 May 2026 | Ridloff Elena | Director | Saletrading plan set in advance · Form 144 notice 11 May 2026 | 3,000 | $87.00 | $261,000 | Form 4 |
| 29 April 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 29 April 2026 | 17,005 | $80.74 | $1.4 million | Form 4 |
| 29 April 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 29 April 2026 | 12,059 | $81.70 | $985,220 | Form 4 |
| 29 April 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 29 April 2026 | 936 | $82.45 | $77,173 | Form 4 |
| 22 April 2026 | Booth Bruce | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 5,900 | $89.96 | $530,764 | Form 4 |
| 22 April 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 88 | $90.08 | $7,927 | Form 4 |
| 22 April 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 12 | $90.08 | $1,081 | Form 4 |
| 22 April 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 22 April 2026 | 300 | $90.00 | $27,000 | Form 4 |
| 15 April 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 15 April 2026 | 1,300 | $90.00 | $117,000 | Form 4 |
| 15 April 2026 | Booth Bruce | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 2,200 | $89.95 | $197,890 | Form 4 |
| 15 April 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 2,750 | $90.10 | $247,775 | Form 4 |
| 15 April 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 385 | $90.10 | $34,688 | Form 4 |
| 14 April 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 9 April 2026 | 1,347 | $90.00 | $121,230 | Form 4 |
| 14 April 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 15 April 2026 | 5,251 | $90.00 | $472,598 | Form 4 |
| 14 April 2026 | Booth Bruce | Director | Saletrading plan set in advance · Form 144 notice 14 April 2026 | 4,159 | $89.97 | $374,185 | Form 4 |
| 10 April 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 9 April 2026 | 2,000 | $87.35 | $174,700 | Form 4 |
| 9 April 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 9 April 2026 | 3,094 | $86.62 | $267,996 | Form 4 |
| 9 April 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 9 April 2026 | 2,670 | $87.11 | $232,586 | Form 4 |
| 9 April 2026 | Goodman Noah | Chief Business Officer | Saletrading plan set in advance · Form 144 notice 9 April 2026 | 2,500 | $89.00 | $222,500 | Form 4 |
| 1 April 2026 | Ridloff Elena | Director | Saletrading plan set in advance · Form 144 notice 1 April 2026 | 3,400 | $85.19 | $289,662 | Form 4 |
| 1 April 2026 | Ridloff Elena | Director | Saletrading plan set in advance · Form 144 notice 1 April 2026 | 1,200 | $86.05 | $103,260 | Form 4 |
| 1 April 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 1 April 2026 | 13,540 | $85.41 | $1.2 million | Form 4 |
| 1 April 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 1 April 2026 | 1,100 | $86.05 | $94,655 | Form 4 |
| 31 March 2026 | Ridloff Elena | Director | Saletrading plan set in advance · Form 144 notice 1 April 2026 | 7,400 | $85.37 | $631,739 | Form 4 |
| 31 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 1 April 2026 | 7,600 | $85.38 | $648,882 | Form 4 |
| 25 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 23 March 2026 | 24,727 | $80.26 | $2.0 million | Form 4 |
| 23 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 23 March 2026 | 22,756 | $76.73 | $1.7 million | Form 4 |
| 23 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 23 March 2026 | 52,975 | $77.21 | $4.1 million | Form 4 |
| 23 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 23 March 2026 | 8,214 | $78.40 | $643,950 | Form 4 |
| 23 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 23 March 2026 | 6,105 | $79.87 | $487,609 | Form 4 |
| 23 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 23 March 2026 | 1,200 | $80.05 | $96,060 | Form 4 |
| 20 March 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 March 2026 | 700 | $77.71 | $54,398 | Form 4 |
| 20 March 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 March 2026 | 600 | $79.24 | $47,546 | Form 4 |
| 20 March 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 March 2026 | 1,200 | $79.94 | $95,933 | Form 4 |
| 11 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 11 March 2026 | 1,765 | $82.13 | $144,955 | Form 4 |
| 11 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 11 March 2026 | 12,882 | $83.10 | $1.1 million | Form 4 |
| 11 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saletrading plan set in advance · Form 144 notice 11 March 2026 | 11,111 | $83.72 | $930,207 | Form 4 |
| 4 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 394 | $84.00 | $33,095 | Form 4 |
| 4 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 2,017 | $85.04 | $171,518 | Form 4 |
| 4 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 1,150 | $85.78 | $98,648 | Form 4 |
| 4 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 358 | $86.62 | $31,012 | Form 4 |
| 4 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 492 | $84.00 | $41,326 | Form 4 |
| 4 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 2,519 | $85.04 | $214,207 | Form 4 |
| 4 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 1,437 | $85.78 | $123,267 | Form 4 |
| 4 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 447 | $86.62 | $38,721 | Form 4 |
| 4 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 492 | $84.00 | $41,326 | Form 4 |
| 4 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 2,519 | $85.04 | $214,207 | Form 4 |
| 4 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 1,437 | $85.78 | $123,267 | Form 4 |
| 4 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 30% rise over three months · 9% below its one-year high · Form 144 notice 2 March 2026 | 447 | $86.62 | $38,721 | Form 4 |
| 2 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 549 | $87.75 | $48,175 | Form 4 |
| 2 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 383 | $88.50 | $33,896 | Form 4 |
| 2 March 2026 | Chadwick Jeremy G | Chief Operating Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 1,107 | $89.66 | $99,251 | Form 4 |
| 2 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 1,510 | $87.75 | $132,504 | Form 4 |
| 2 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 1,055 | $88.50 | $93,368 | Form 4 |
| 2 March 2026 | Gollob Jared | Chief Medical Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 3,048 | $89.66 | $273,276 | Form 4 |
| 2 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 2,039 | $87.75 | $178,924 | Form 4 |
| 2 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 1,424 | $88.50 | $126,025 | Form 4 |
| 2 March 2026 | Jacobs Bruce N. | Chief Financial Officer | Saleafter a 35% rise over three months · 5% below its one-year high · Form 144 notice 2 March 2026 | 4,113 | $89.66 | $368,761 | Form 4 |
| 2 March 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance | 71,814 | $90.13 | $6.5 million | Form 4 |
| 2 March 2026 | Booth Bruce, see footnote | Director | Saletrading plan set in advance | 10,052 | $90.13 | $905,987 | Form 4 |
| 25 February 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 25 February 2026 | 19,764 | $89.78 | $1.8 million | Form 4 |
| 25 February 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 25 February 2026 | 5,434 | $90.39 | $491,179 | Form 4 |
| 25 February 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 25 February 2026 | 3,293 | $91.76 | $302,166 | Form 4 |
| 25 February 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 25 February 2026 | 1,501 | $92.81 | $139,308 | Form 4 |
| 25 February 2026 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 25 February 2026 | 8 | $93.49 | $748 | Form 4 |
| 20 February 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 February 2026 | 1,900 | $87.06 | $165,410 | Form 4 |
| 20 February 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 February 2026 | 600 | $88.10 | $52,860 | Form 4 |
| 20 January 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 January 2026 | 400 | $66.68 | $26,672 | Form 4 |
| 20 January 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 January 2026 | 4,900 | $67.99 | $333,145 | Form 4 |
| 20 January 2026 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 20 January 2026 | 200 | $68.52 | $13,704 | Form 4 |
| 31 December 2025 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 31 December 2025 | 23,986 | $77.95 | $1.9 million | Form 4 |
| 31 December 2025 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 31 December 2025 | 6,014 | $78.52 | $472,211 | Form 4 |
| 17 December 2025 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 17 December 2025 | 14,505 | $81.56 | $1.2 million | Form 4 |
| 17 December 2025 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 17 December 2025 | 7,959 | $82.34 | $655,362 | Form 4 |
| 17 December 2025 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 17 December 2025 | 4,099 | $83.45 | $342,064 | Form 4 |
| 17 December 2025 | Esposito Pamela | Director | Saletrading plan set in advance · Form 144 notice 17 December 2025 | 1,000 | $84.07 | $84,070 | Form 4 |
| 12 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 91% rise over three months · 5% below its one-year high | 570 | $91.04 | $51,893 | Form 4 |
| 12 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 91% rise over three months · 5% below its one-year high | 108 | $91.04 | $9,832 | Form 4 |
| 11 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 90% rise over three months · 7% below its one-year high | 5,125 | $91.23 | $467,554 | Form 4 |
| 11 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 90% rise over three months · 7% below its one-year high | 976 | $91.23 | $89,040 | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 31,459 | $88.64 | $2.8 million | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 17,825 | $89.25 | $1.6 million | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 10,545 | $90.14 | $950,526 | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 47,349 | $92.41 | $4.4 million | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 85,862 | $93.20 | $8.0 million | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 5,979 | $88.64 | $529,979 | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 3,391 | $89.25 | $302,647 | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 2,001 | $90.14 | $180,370 | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 9,060 | $92.41 | $837,235 | Form 4 |
| 10 December 2025 | Booth Bruce, see footnote | Director | Saleafter a 107% rise over three months · 5% below its one-year high | 16,338 | $93.20 | $1.5 million | Form 4 |
| 11 December 2025 | Baker Bros. Advisors Lp, see Footnotes | Director | Purchaseafter a 90% rise over three months · 7% below its one-year high | 167,192 | $86.00 | $14.4 million | Form 4 |
| 11 December 2025 | Baker Bros. Advisors Lp, see Footnotes | Director | Purchaseafter a 90% rise over three months · 7% below its one-year high | 1,838,621 | $86.00 | $158.1 million | Form 4 |
| 8 December 2025 | Albers Jeffrey W. | Director | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 2,748 | $89.32 | $245,460 | Form 4 |
| 8 December 2025 | Albers Jeffrey W. | Director | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 2,252 | $90.30 | $203,363 | Form 4 |
| 8 December 2025 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 100,000 | $89.17 | $8.9 million | Form 4 |
| 8 December 2025 | Gollob Jared | Chief Medical Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 13,759 | $87.37 | $1.2 million | Form 4 |
| 8 December 2025 | Gollob Jared | Chief Medical Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 18,357 | $88.02 | $1.6 million | Form 4 |
| 8 December 2025 | Gollob Jared | Chief Medical Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 3,929 | $89.43 | $351,356 | Form 4 |
| 8 December 2025 | Gollob Jared | Chief Medical Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 8,562 | $90.12 | $771,630 | Form 4 |
| 8 December 2025 | Gollob Jared | Chief Medical Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 3,300 | $91.46 | $301,831 | Form 4 |
| 8 December 2025 | Gollob Jared | Chief Medical Officer | Saletrading plan set in advance · Form 144 notice 8 December 2025 | 1,400 | $92.19 | $129,066 | Form 4 |
| 29 October 2025 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 29 October 2025 | 1,862 | $59.72 | $111,203 | Form 4 |
| 29 October 2025 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 29 October 2025 | 24,511 | $61.02 | $1.5 million | Form 4 |
| 29 October 2025 | Mainolfi Nello | Chief Executive Officer | Saletrading plan set in advance · Form 144 notice 29 October 2025 | 3,627 | $61.46 | $222,907 | Form 4 |