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Johnson & Johnson: Q4 FY2025 earnings call

What management said about Q4 FY2025, from the documents filed with the SEC on 21 January 2026: press release. Guidance figures: 6 new. The quarter’s numbers.

Key takeaways

  • Fourth-quarter sales rose 9.1%: Fourth-quarter reported sales were $24.6 billion, up 9.1%. Operational growth was 7.1% and adjusted operational growth 6.1%, both excluding currency; adjusted operational also excludes acquisitions and divestitures. Source
  • Full-year sales rose 6.0%: Full-year 2025 reported sales were $94.2 billion, up 6.0%, against an October 2025 estimate of $93.5 billion to $93.9 billion. Operational growth was 5.3% and adjusted operational growth 4.2%. Source
  • Innovative Medicine grew 5.3% operationally: Full-year Innovative Medicine sales were $60.4 billion, with worldwide operational growth of 5.3%. Net acquisitions added 1.2%, primarily from CAPLYTA. Source
  • Several U.S. FDA approvals announced: Approvals named include CAPLYTA for major depressive disorder, RYBREVANT FASPRO with LAZCLUZE for non-small cell lung cancer, and DARZALEX FASPRO for high-risk smoldering myeloma. Source
  • MajesTEC-3 supports TECVAYLI combination: Phase 3 MajesTEC-3 results support TECVAYLI plus DARZALEX FASPRO as a potential standard of care as early as second line for relapsed or refractory myeloma. Source
  • 2026 guidance issued in ranges: Management issued guidance for 2026 in this release. It covers reported sales, operational sales, adjusted operational sales and adjusted EPS, each given as a range with a midpoint. Source
  • Free cash flow estimated at $19.7 billion: Full-year 2025 free cash flow is estimated at about $19.7 billion, against $19,842 million in 2024. It is a non-GAAP measure, defined as operating cash flow less capital additions. Source
  • Orthopaedics business to be separated: The company announced its intent to separate its Orthopaedics business. The release gives no timetable for the separation. Source

“2025 was a catapult year for Johnson & Johnson, fueled by the strongest portfolio and pipeline in our history”

Joaquin Duato, Chairman and Chief Executive Officer, Johnson & Johnson

Guidance

AreaPeriodFigureAgainst last quarter
Adjusted operational sales growth SourceFull year 20265.4% - 6.4%; midpoint 5.9%New
Operational sales SourceFull year 2026$99.5B - $100.5B; midpoint $100.0B; growth 5.7% - 6.7%, midpoint 6.2%New
Estimated reported sales SourceFull year 2026$100.0B - $101.0B; midpoint $100.5B; growth 6.2% - 7.2%, midpoint 6.7%New
Adjusted operational diluted EPS SourceFull year 2026$11.28 - $11.48; midpoint $11.38; growth 4.5% - 6.5%, midpoint 5.5%New
Adjusted diluted EPS SourceFull year 2026$11.43 - $11.63; midpoint $11.53; growth 5.9% - 7.9%, midpoint 6.9%New
Euro average rate assumption SourceJanuary 2026$1.17New

What changed from last quarter

  • New guidance: Management issued 2026 guidance for reported sales, operational sales, adjusted operational sales and adjusted EPS. Source
  • New: Acquisition of Halda Therapeutics completed, adding a platform for next-generation oral cancer therapies. Source
  • New: Intent to separate the Orthopaedics business announced. Source
  • New: Agreement with the U.S. government on medicine access and costs, with U.S. manufacturing and innovation investments. Source

Fourth-quarter and full-year results

  • Fourth-quarter sales rose 9.1%: Fourth-quarter reported sales were $24.6 billion, up 9.1%. Operational growth was 7.1% and adjusted operational growth 6.1%, both excluding currency; adjusted operational also excludes acquisitions and divestitures. Source
  • Full-year sales rose 6.0%: Full-year 2025 reported sales were $94.2 billion, up 6.0%, against an October 2025 estimate of $93.5 billion to $93.9 billion. Operational growth was 5.3% and adjusted operational growth 4.2%. Source
  • Fourth-quarter EPS includes Halda charge: Fourth-quarter diluted EPS was $2.10 and adjusted EPS $2.46, both including $(0.10) from the Halda Therapeutics acquisition. Net earnings were $5,116 million, up 49.1%. Source

Segments and regions

  • Innovative Medicine grew 5.3% operationally: Full-year Innovative Medicine sales were $60.4 billion, with worldwide operational growth of 5.3%. Net acquisitions added 1.2%, primarily from CAPLYTA. Source
  • MedTech grew 5.4% operationally: Full-year MedTech sales were $33.8 billion, with operational growth of 5.4%. Net acquisitions added 1.1%, primarily from Shockwave. Source
  • U.S. and international full-year sales: U.S. full-year sales were $53.8 billion, up 6.9%. International sales were $40.4 billion, up 5.0% reported and 3.3% adjusted operational; international fourth-quarter sales rose 11.3%. Source
  • Fourth-quarter segment sales rose: Fourth-quarter Innovative Medicine sales were $15.8 billion, up 10.0%. MedTech sales were $8.8 billion, up 7.5%, with 5.9% adjusted operational growth. Source

“Last year kicked off a new era of accelerated growth, driven by medical innovation that is transforming lives in our six key businesses: Oncology, Immunology, Neuroscience, Cardiovascular, Surgery, and Vision.”

Joaquin Duato, Chairman and Chief Executive Officer, Johnson & Johnson

Growth drivers by franchise

  • Oncology products drove Innovative Medicine growth: Oncology products named as growth drivers were DARZALEX, CARVYKTI, ERLEADA, and RYBREVANT with LAZCLUZE, within Innovative Medicine full-year segment commentary. Source
  • Immunology and Neuroscience products also grew: TREMFYA and SIMPONI/SIMPONI ARIA were named as Immunology growth drivers, and SPRAVATO as a Neuroscience driver, in the full-year segment commentary. Source
  • MedTech growth from electrophysiology and Abiomed: Full-year MedTech growth was driven primarily by electrophysiology products and Abiomed in Cardiovascular, and by wound closure products in General Surgery. Source

Approvals and clinical data

  • Several U.S. FDA approvals announced: Approvals named include CAPLYTA for major depressive disorder, RYBREVANT FASPRO with LAZCLUZE for non-small cell lung cancer, and DARZALEX FASPRO for high-risk smoldering myeloma. Source
  • MajesTEC-3 supports TECVAYLI combination: Phase 3 MajesTEC-3 results support TECVAYLI plus DARZALEX FASPRO as a potential standard of care as early as second line for relapsed or refractory myeloma. Source
  • Subcutaneous amivantamab response data: Subcutaneous amivantamab produced a 45 percent overall response rate, with median duration of 7.2 months, in recurrent or metastatic head and neck cancer. Source
  • TREMFYA Crohn's remission at two years: TREMFYA showed durable remission in Crohn's disease at two years. Icotrokinra data in ulcerative colitis were reported through 28 weeks in a once-daily pill. Source

“In each of these important areas, our leadership is expanding driven by game-changing science and technology.”

Joaquin Duato, Chairman and Chief Executive Officer, Johnson & Johnson

2026 guidance

  • 2026 guidance issued in ranges: Management issued guidance for 2026 in this release. It covers reported sales, operational sales, adjusted operational sales and adjusted EPS, each given as a range with a midpoint. Source
  • Euro rate assumption is illustrative: The reported sales estimate uses an illustrative euro average rate of $1.17 for January 2026, which the release marks as for illustrative purposes only. Source
  • Adjusted EPS guidance excludes special items: Adjusted EPS guidance excludes intangible amortization expense and special items, as the release footnotes state. Source

Cash flow and earnings

  • Full-year EPS and net earnings rose: Full-year diluted EPS was $11.03, up 90.5%, and net earnings were $26,804 million, up 90.6%. Full-year adjusted EPS was $10.79, up 8.1%. Source
  • Free cash flow estimated at $19.7 billion: Full-year 2025 free cash flow is estimated at about $19.7 billion, against $19,842 million in 2024. It is a non-GAAP measure, defined as operating cash flow less capital additions. Source
  • Fourth-quarter adjusted net earnings rose: Adjusted net earnings were $6,009 million in the fourth quarter, up 21.5% from $4,946 million, excluding intangible amortization and special items. Source

Strategy, deals and policy

  • Orthopaedics business to be separated: The company announced its intent to separate its Orthopaedics business. The release gives no timetable for the separation. Source
  • Halda platform acquisition completed: The company completed the Halda acquisition, which the release describes as adding a novel platform for cancer treatment and oral therapies. Source
  • Agreement with U.S. government announced: The company reached an agreement with the U.S. government on improving medicine access and lowering costs, alongside U.S. manufacturing and innovation investments. Source

Coming up, as management said on 21 January 2026

  • Cash flow from operations to follow: The company will publish operating cash flow, the GAAP comparison for free cash flow, in later SEC filings. Source
  • OTTAVA review at U.S. FDA: The OTTAVA Robotic Surgical System was submitted to the U.S. FDA; the release gives no decision date. Source

Figures management reported

FigureReported
Innovative Medicine sales, full year 2025 Source$60,401 million
MedTech sales, full year 2025 Source$33,792 million
Phase 3 trial readout SourceMajesTEC-3, TECVAYLI plus DARZALEX FASPRO
FDA approval SourceAKEEGA, BRCA2-mutated metastatic castration-sensitive prostate cancer
FDA approval SourceCAPLYTA for major depressive disorder

Risks management discussed

  • Demand: The release names STELARA as an offset to Innovative Medicine full-year growth, at about 1,040 basis points. Source
  • External: Currency added 2.0 points to fourth-quarter reported growth, so reported sales growth ran above operational growth. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.