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Jazz Pharmaceuticals (JAZZ) FY2025 results: revenue $4.3 billion, up 4.9% on the year

Jazz Pharmaceuticals plc (JAZZ) reported revenue of $4.3 billion for fiscal 2025, the year ended 31 December 2025, up 4.9% on the year before. Net income was -$356 million, and diluted earnings per share $-5.84. The figures are the company's own, from the 10-K it filed with the SEC on 24 February 2026.

Revenue
$4.3 billion
+4.9% on the year
FY2018FY2025
Operating margin
-10.1%
17.6% a year earlier
FY2018FY2025
Net income
-$356 million
FY2018FY2025
Diluted EPS
-$5.84
FY2018FY2025

this yearthe year beforeHover a bar for its figure.

The year in brief

What management said about the year

Guidance figures: 8 new.

  • Fourth-quarter revenue reached highest ever: Total revenues were $4.3 billion for 2025, up 5%, and $1.2 billion for 4Q25, up 10%; the company called 4Q25 its highest revenue quarter ever.
  • Xywav sales grew 12% in 2025: Xywav net product sales were $1.7 billion for 2025, up 12%, and $465 million for 4Q25, up 16%; the total sleep franchise exceeded $2 billion for 2025.
  • Modeyso sales since August launch: Modeyso net product sales were $48 million for 2025 since the August 2025 launch, and $37 million for 4Q25.
  • Cost of product sales rose on mix: GAAP gross margin on product sales was 87.5% for 2025 against 88.3%, and non-GAAP 91.6% against 92.3%; the company attributed the cost increase to product mix.
  • SG&A rose with two litigation settlements: GAAP SG&A was $1.81 billion for 2025, or 42.4% of total revenues, against $1.39 billion, including Xyrem antitrust settlements of $234 million and an Avadel settlement of $90 million.
Read the Q4 FY2025 earnings call summary

From this 10-K

Jazz Pharmaceuticals is a biopharmaceutical company that develops and sells medicines for rare diseases, with products for sleep disorders, epilepsies and cancers. It is an Irish public limited company, formed in 2005 as Azur Pharma and combined with Jazz Pharmaceuticals, Inc. in 2012, and its headquarters are in Dublin, Ireland.

Jazz Pharmaceuticals plc, the 10-K for 2025

Jazz Pharmaceuticals is a biopharmaceutical company that develops and sells medicines for rare diseases, with products for sleep disorders, epilepsies and cancers. It is an Irish public limited company, formed in 2005 as Azur Pharma and combined with Jazz Pharmaceuticals, Inc. in 2012, and its headquarters are in Dublin, Ireland.

Sleep

Xywav is an oxybate oral solution approved by the FDA in July 2020 for cataplexy or daytime sleepiness in patients seven years of age and older with narcolepsy, and in August 2021 for IH in adults, a sleep disorder that the filing describes as including chronic sleepiness during the day and prolonged nighttime sleep. It contains 92% less sodium than the company's high-sodium oxybate, Xyrem. Narcolepsy affects an estimated one in 2,000 people in the U.S.

Epilepsy

Epidiolex, a cannabidiol oral solution, was approved by the FDA in 2018 and treats seizures associated with LGS, DS or TSC in patients one year of age or older. The filing describes LGS and DS as severe childhood-onset, drug-resistant epilepsy syndromes. In the EU and Great Britain it is sold as Epidyolex.

Cancer

Ziihera (zanidatamab), a bispecific antibody licensed from Zymeworks, received accelerated FDA approval in November 2024 for adults with previously treated HER2-positive BTC. Modeyso (dordaviprone) received accelerated approval in August 2025 for patients 1 year of age and older with diffuse midline glioma harboring an H3 K27M mutation. Zepzelca (lurbinectedin), licensed from PharmaMar, treats metastatic SCLC, and in October 2025 was approved as a first-line maintenance treatment in combination with atezolizumab. Rylaze treats ALL or LBL in patients who have developed hypersensitivity to E. coli-derived asparaginase. It also sells Vyxeos, used in AML, and Defitelio, which treats VOD following HSCT.

How it sells and makes its products

It has its own commercial operations in the U.S., Europe, Australia and Canada and uses distributors in other markets. In the U.S., its sales teams promote its products to doctors in the relevant specialties, and other teams handle insurers, institutions and distribution to wholesalers, pharmacies and hospitals. It makes Xywav and Xyrem in Athlone, Ireland, Epidiolex at Kent Science Park in the U.K., and defibrotide drug substance in Villa Guardia, Italy, and relies on contract manufacturers for its other products.

People

At December 31, 2025, it employed approximately 2,890 people, approximately 53% in the U.S. and the rest mainly in the U.K., Ireland and the EU. More than 740 of them work in research and development.

From Jazz Pharmaceuticals' annual report on Form 10-K for the year ended 31 December 2025. The filing

Written from the 10-K filed 24 February 2026: read the full 10-K.

The four quarters: Q1 FY2025 · Q2 FY2025 · Q3 FY2025 · Q4 FY2025

Income statement (profit and loss)

$ millionFY2025FY2024FY2023On the yearLast 8 years
Revenue4,2684,0693,834+4.9%
Research and development783884850-11.5%
Selling, general and administrative1,8091,3851,343+30.6%
Operating income-430717579
Operating margin-10.1%17.6%15.1%
Interest expensen/an/a32.8
Pre-tax income-628470298
Income tax-272-91.4-120
Effective tax raten/a-19.4%-40.2%
Net income-356560415
Net margin-8.3%13.8%10.8%
Diluted EPS-$5.84$8.65$6.10
$ million except per share.
Read moreFree cash flow is operating cash flow less capital expenditure; the effective tax rate is income tax over pre-tax income; margins are the line over revenue. Gross profit is revenue less cost of revenue, and operating income is revenue less the company's own total costs, where the statement does not print those lines. Those four are arithmetic on the filed numbers; everything else is as filed. Money is in $ million as the company files it, or in $ billion by the switch above the tables; per share figures and share counts are as they are.

Cash flow

$ millionFY2025FY2024FY2023On the yearLast 8 years
Operating cash flow1,3561,3961,092-2.9%
Capital expenditure58.838.124.0+54.3%
Free cash flow1,2971,3581,068-4.5%
Free cash flow margin30.4%33.4%27.9%
Cash from investing-1,510-508-163
Cash from financing-87320.5-305
Depreciation and amortisation41.632.830.4+26.8%
Share-based compensation291248227+17.4%
Buybacks125311270-59.9%
Diluted shares, weighted61m66m72m-7.6%
Shares outstanding at period end61m61m62m+1.3%

Balance sheet

$ millionFY2025FY2024FY2023On the yearLast 8 years
Shareholders' equity4,3194,0943,737+5.5%
Debt5,3586,1095,713-12.3%
Operating lease liabilities50.938.959.2+30.7%
Finance lease liabilities3.44.65.0-24.6%
Other liabilities1,9281,7661,879+9.2%
Total liabilities and equity11,65912,01211,393-2.9%
Goodwill1,8291,7161,753+6.6%
Intangible assets4,4304,7565,418-6.9%
Securities held for sale or to maturity2,4422,9931,626-18.4%
Cash and equivalents1,3922,4131,506-42.3%
Receivables831717706+15.9%
Inventory417480597-13.2%
Other assets319n/an/a
Total assets11,65912,01211,393-2.9%

10-K for the year ended 31 December 2025, filed 24 February 2026: the filing.