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Gilead Sciences, Inc.: Q2 FY2026 earnings call

What management said about Q2 FY2026, from the documents filed with the SEC on 4 August 2026: press release. Guidance figures: 4 raised, 4 lowered, 1 kept. The quarter’s numbers.

Key takeaways

  • Revenue rose 10% on base business: Total revenues rose 10% to $7.8 billion, with the company citing higher HIV, Trodelvy and Livdelzi sales, partly offset by lower Veklury, Cell Therapy and HCV sales, plus royalty and other revenue from a prior IP sale. Source
  • Diluted loss reflects acquired IPR&D: Diluted loss per share was $(8.45) against $1.56 a year earlier; the company attributed the decrease mainly to $(9.08) per share of acquired IPR&D expenses tied to Arcellx, Tubulis and Ouro Medicines. Source
  • HIV sales up 12%: HIV product sales rose 12% to $5.7 billion, which the company attributed to higher average realized price and demand. Source
  • ISLEND Phase 3 results positive: Positive Phase 3 ISLEND-1 and ISLEND-2 results with Merck for once-weekly islatravir and lenacapavir in adults with HIV who are virologically suppressed. Source
  • Cash fell to $3.2 billion: Cash, equivalents and marketable debt securities fell to $3.2 billion from $10.6 billion at December 31, 2025, mainly on acquisition outflows and debt repayments. Source
  • Product sales guidance raised: Full-year product sales guidance is $30.1 to $30.4 billion, and excluding Veklury $29.8 to $30.1 billion, while Veklury was cut to about $300 million. Source
  • Non-GAAP loss per share narrowed: Full-year non-GAAP diluted loss per share guidance is $(0.65) to $(0.30), while GAAP guidance moved to $(3.75) to $(3.40). Source

“HIV sales grew 12%, reflecting continued strength in treatment and the rapid expansion of our PrEP business, supporting an increase in our base business revenue expectations for 2026”

Daniel O’Day, Gilead’s Chairman and Chief Executive Officer

Guidance

AreaPeriodFigureAgainst last quarter
Product sales SourceFull year 2026$30,100 to $30,400 millionRaised from $30,000 to $30,400 million
Product sales excluding Veklury SourceFull year 2026$29,800 to $30,100 millionRaised from $29,400 to $29,800 million
Veklury SourceFull year 2026~$300 millionLowered from ~$600 million
GAAP diluted loss per share SourceFull year 2026$(3.75) to $(3.40)Lowered from $(3.25) to $(2.85)
Non-GAAP diluted loss per share SourceFull year 2026$(0.65) to $(0.30)Raised from $(1.05) to $(0.65)
GAAP projected operating income (loss) SourceFull year 2026$(2,250) to $(1,850) millionLowered from $(1,000) to $(500) million
Non-GAAP projected operating income SourceFull year 2026$2,900 to $3,300 millionRaised from $2,400 to $2,900 million
Projected product gross margin SourceFull year 2026GAAP ~79.0%; non-GAAP ~87.0%Kept
GAAP projected effective tax rate SourceFull year 2026~(80%) to ~(90%)
Non-GAAP projected effective tax rate SourceFull year 2026~140% to ~115%
Effective tax rate excluding acquired IPR&D SourceFull year 2026~21% GAAP; ~20% non-GAAP
Acquired IPR&D charges SourceFull year 2026$11.1 billion, about $9.08 per shareLowered from $11.5 billion, about $9.50 per share

What changed from last quarter

  • Guidance raised: Full-year product sales guidance low end raised from $30,000 million to $30,100 million. Source
  • Guidance raised: Full-year product sales excluding Veklury guidance raised on both ends. Source
  • Guidance lowered: Full-year Veklury sales guidance cut to about $300 million from about $600 million. Source
  • Guidance lowered: Full-year GAAP diluted loss per share guidance moved to $(3.75) to $(3.40) from $(3.25) to $(2.85). Source
  • Guidance raised: Full-year non-GAAP diluted loss per share guidance moved to $(0.65) to $(0.30) from $(1.05) to $(0.65). Source
  • Guidance lowered: Full-year GAAP projected operating loss range widened to $(2,250) to $(1,850) million. Source
  • Guidance raised: Full-year non-GAAP projected operating income raised to $2,900 to $3,300 million. Source
  • Guidance kept: Projected product gross margin kept at about 79.0% GAAP and 87.0% non-GAAP. Source
  • New: Tubulis acquisition reported as completed; the May update described a definitive agreement. Source
  • New: Ouro Medicines acquisition reported as completed, with Lakefront sharing the upfront payment; May described a definitive agreement. Source
  • New: Hepcludex received FDA accelerated approval for chronic hepatitis delta virus; described as the first and only FDA-approved HDV treatment in the U.S. Source
  • New: Trodelvy received FDA approval for first-line triple-negative breast cancer, as a single agent or with Keytruda. Source
  • Ended: Phase 3 EVOKE-03 study of Trodelvy with Keytruda in first-line lung cancer discontinued. Source
  • New: FDA accepted a supplemental NDA for once-weekly oral Yeztugo for PrEP. Source
  • New: Five-year collaboration with the World Health Organization renewed on visceral leishmaniasis. Source

Results and growth drivers

  • Revenue rose 10% on base business: Total revenues rose 10% to $7.8 billion, with the company citing higher HIV, Trodelvy and Livdelzi sales, partly offset by lower Veklury, Cell Therapy and HCV sales, plus royalty and other revenue from a prior IP sale. Source
  • Diluted loss reflects acquired IPR&D: Diluted loss per share was $(8.45) against $1.56 a year earlier; the company attributed the decrease mainly to $(9.08) per share of acquired IPR&D expenses tied to Arcellx, Tubulis and Ouro Medicines. Source
  • Non-GAAP loss per share: Non-GAAP diluted loss per share was $(6.75) against $2.01 a year earlier; the company cited higher non-GAAP SG&A and non-GAAP income tax, partly offset by higher revenues. Source
  • Operating result swung to loss: Operating loss was $(10,394) million against operating income of $2,474 million a year earlier; the six-month operating loss was $(7,808) million. Source

HIV and liver disease franchise

  • HIV sales up 12%: HIV product sales rose 12% to $5.7 billion, which the company attributed to higher average realized price and demand. Source
  • Descovy and Biktarvy growth: Descovy sales rose 48% to $967 million on higher average realized price and demand; Biktarvy rose 7% to $3.8 billion, with favorable inventory dynamics also cited. Source
  • Yeztugo PrEP sales climb: Yeztugo sales reached $232 million from $15 million a year earlier; the company cited the rapid expansion of its PrEP business. Source
  • Liver Disease sales rose 10%: Liver Disease sales rose 10% to $877 million on higher Livdelzi demand, with chronic hepatitis B products and Hepcludex also contributing; HCV sales declined. Source

“We also made significant clinical progress with three FDA approvals and three positive Phase 3 updates.”

Daniel O’Day, Gilead’s Chairman and Chief Executive Officer

Oncology and cell therapy

  • Trodelvy sales up 26%: Trodelvy sales rose 26% to $457 million on higher demand; the company also reported FDA first-line triple-negative breast cancer approval during the quarter. Source
  • Cell Therapy sales declined 14%: Cell Therapy sales fell 14% to $417 million; Yescarta fell 12% and Tecartus fell 24%, attributed to in-class and out-of-class competition. Source
  • Veklury sales down 81%: Veklury sales fell 81% to $23 million on lower COVID-19-related hospitalizations; full-year Veklury guidance was cut to about $300 million. Source

Costs, margins and tax

  • Product gross margin edged up: Product gross margin was 79.3%, against 78.7% a year earlier; non-GAAP product gross margin was flat at 86.9%. Source
  • R&D rose on acquisition costs: GAAP R&D rose to $1.8 billion on integration and acquisition-related costs; non-GAAP R&D fell to $1.4 billion on lower oncology clinical study activity. Source
  • SG&A up on integration and HIV: GAAP SG&A rose to $1.9 billion on integration costs and HIV promotion; non-GAAP SG&A rose to $1.5 billion, mainly on higher HIV promotional activities. Source
  • Immunomedics IPR&D impairment recorded: An IPR&D impairment of $1,750 million on assets previously acquired from Immunomedics was recorded and excluded from non-GAAP results. Source
  • Tax rate turned negative: Effective tax rate was (2.4)% against 19.3% a year earlier; the company said this primarily reflects non-deductible acquired IPR&D expenses. Source

“We look forward to delivering on our many opportunities in the second half of the year including another two potential launches in oncology and HIV.”

Daniel O’Day, Gilead’s Chairman and Chief Executive Officer

Acquisitions and pipeline

  • Tubulis brings ADC assets: Tubulis brings GS-8824, a NaPi2b-directed topoisomerase-I inhibitor ADC, and a platform to develop novel ADCs. Source
  • Ouro Medicines adds T cell engager: Ouro Medicines adds gamgertamig, a BCMAxCD3 T cell engager for autoimmune diseases; Lakefront equally shares the upfront and milestone payments. Source
  • ASCENT and KITE data presented: New ASCENT-03 and ASCENT-04 analyses were presented at ASCO, and updated Phase 1 KITE-753 results were presented at EHA. Source
  • ISLEND Phase 3 results positive: Positive Phase 3 ISLEND-1 and ISLEND-2 results with Merck for once-weekly islatravir and lenacapavir in adults with HIV who are virologically suppressed. Source
  • IDEAL supports Livdelzi in PBC: Phase 3 IDEAL results support potential use of Livdelzi in PBC patients with elevated ALP who remain inadequately controlled on UDCA or are UDCA-intolerant. Source

Cash, debt and shareholder returns

  • Cash fell to $3.2 billion: Cash, equivalents and marketable debt securities fell to $3.2 billion from $10.6 billion at December 31, 2025, mainly on acquisition outflows and debt repayments. Source
  • Operating and free cash flow: Operating cash flow was $3.6 billion in the quarter, and free cash flow was $3.4 billion after $140 million of capital expenditure. Source
  • Dividends and buybacks in quarter: The company paid $1.0 billion in dividends and repurchased $355 million of common stock during the quarter. Source

Financing and corporate actions

  • Debt raised in quarter: Gilead issued $3.0 billion of senior unsecured notes and borrowed $1.1 billion under a one-year term loan facility. Source
  • WHO leishmaniasis collaboration renewed: A renewed five-year collaboration with the World Health Organization commits funding, strategic support and AmBisome donations toward eliminating visceral leishmaniasis. Source
  • Remdesivir donated for Ebola response: 2,000 vials of remdesivir were donated to Uganda for the Ebola Bundibugyo outbreak; the company notes the drug is not approved for this use. Source

Full-year guidance revision

  • Product sales guidance raised: Full-year product sales guidance is $30.1 to $30.4 billion, and excluding Veklury $29.8 to $30.1 billion, while Veklury was cut to about $300 million. Source
  • Non-GAAP loss per share narrowed: Full-year non-GAAP diluted loss per share guidance is $(0.65) to $(0.30), while GAAP guidance moved to $(3.75) to $(3.40). Source
  • Acquired IPR&D drives full-year loss: Full-year guidance includes about $9.08 per share of acquired IPR&D charges from $11.1 billion, net of the Lakefront collaboration and related taxes. Source
  • Operating loss and income guidance: GAAP projected operating loss is now $(2,250) to $(1,850) million; non-GAAP projected operating income rose to $2,900 to $3,300 million. Source

Coming up, as management said on 4 August 2026

  • Once-weekly Yeztugo decision due: FDA target action date for the once-weekly oral Yeztugo formulation for PrEP is February 2, 2027. Source
  • Oncology and HIV launches in second half: Management cites two potential launches, in oncology and HIV, in the second half of 2026. Source
  • Third-quarter dividend payment: The $0.82 per share dividend declared for the third quarter is payable September 29, 2026, to holders of record on September 15, 2026. Source

Figures management reported

FigureReported
Biktarvy product sales Source$3.8 billion, up 7%
Descovy product sales Source$967 million, up 48%
Trodelvy product sales Source$457 million, up 26%
Livdelzi product sales Source$167 million, up from $78 million
Yescarta product sales Source$346 million, down 12%
Veklury product sales Source$23 million, down 81%
Pipeline Phase 3 results SourcePositive ISLEND-1 and ISLEND-2 results
FDA approvals and Phase 3 updates SourceThree FDA approvals; three positive Phase 3 updates
R&D expenses Source$1.8 billion GAAP; $1.4 billion non-GAAP
Phase 3 discontinuation SourceEVOKE-03 discontinued

Risks management discussed

  • Demand: Cell Therapy sales declined on in-class and out-of-class competition, with Yescarta down 12% and Tecartus down 24%. Source
  • External: Veklury sales depend on COVID-19-related hospitalization rates, which were lower in the quarter. Source
  • Financial: Cash and marketable debt securities fell sharply during the first half, after acquisition outflows and debt repayments. Source
  • Financial: Acquired IPR&D expenses are not tax-deductible, which drives the negative effective tax rate for the quarter and the full year. Source
  • Operational: SG&A rose on integration costs from recent acquisitions. Source
  • Regulatory: The EVOKE-03 study was stopped after the external Data Monitoring Committee reviewed the final analysis. Source

Earlier plans management reported on

  • Not stated: May plan for 2026. The August release cites three FDA approvals and three positive Phase 3 updates for the quarter, without restating the full-year count.
  • Not stated: The May release described Tubulis closing as subject to regulatory filings; the August release reports the acquisition as completed. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.