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Gilead Sciences, Inc.: Q4 FY2025 earnings call

What management said about Q4 FY2025, from the documents filed with the SEC on 10 February 2026: press release. Guidance figures: 9 new. The quarter’s numbers.

Key takeaways

  • Full-year product sales rose 1%: Full-year product sales rose 1% to $28.9 billion, and product sales excluding Veklury rose 4% to $28.0 billion. Total revenues rose 2% to $29.4 billion. Source
  • Non-GAAP EPS rose 77%: Full-year non-GAAP diluted EPS was $8.15, up from $4.62, primarily on lower acquired IPR&D expenses, higher revenues and lower SG&A expenses. Source
  • HIV sales grew on demand: Full-year HIV product sales rose 6% to $20.8 billion, driven by demand for HIV treatment and prevention. Source
  • Quarterly dividend raised to $0.82: The Board declared a $0.82 quarterly dividend for Q1 2026, up from the $0.79 declared for Q4 2025. Source
  • BIC/LEN met Phase 3 endpoints: Phase 3 ARTISTRY-1 and ARTISTRY-2 trials of daily oral bictegravir and lenacapavir met primary endpoints against baseline regimens and against Biktarvy. Source
  • ASCENT-07 did not meet endpoint: Phase 3 ASCENT-07 trial of Trodelvy in first-line metastatic breast cancer did not meet its progression-free survival primary endpoint. Overall survival was not yet mature, with an early favorable trend. Source
  • U.S. government drug-cost agreement: Gilead announced an agreement with the U.S. government to lower the cost of medicines for Americans. The release gives no financial terms. Source

“As we continue to increase our positive impact on healthcare, Gilead is well positioned for continued growth in 2026 and beyond.”

Daniel O’Day, Gilead’s Chairman and Chief Executive Officer

Guidance

AreaPeriodFigureAgainst last quarter
Product sales SourceFull year 2026$29,600 million to $30,000 millionNew
Product sales excluding Veklury SourceFull year 2026$29,000 million to $29,400 millionNew
Veklury SourceFull year 2026$600 millionNew
Diluted EPS SourceFull year 2026$6.75 to $7.15New
Non-GAAP diluted EPS SourceFull year 2026$8.45 to $8.85New
GAAP operating income SourceFull year 2026$11,400 million to $11,900 millionNew
Non-GAAP operating income SourceFull year 2026$13,800 million to $14,300 millionNew
Product gross margin SourceFull year 2026GAAP about 79.0%; non-GAAP about 87.0%New
Effective tax rate SourceFull year 2026GAAP about 21%; non-GAAP about 20%New

What changed from last quarter

  • New guidance: Full-year 2026 guidance for product sales, EPS and operating income is given for the first time in this release. Source
  • Phase 3 STAR-221 study was discontinued with Arcus, and the Phase 2 EDGE-Gastric study will also be discontinued. Source
  • New: Quarterly dividend declared at $0.82 per share for Q1 2026. Source
  • New: Appointed Keeley Cain Wettan as Executive Vice President, General Counsel, Legal and Compliance. Source
  • New: Announced an agreement with the U.S. government to lower the cost of medicines for Americans. Source
  • New: Exercised option to license two herpes simplex virus helicase-primase inhibitor programs from Assembly Biosciences. Source

Results and growth drivers

  • Full-year product sales rose 1%: Full-year product sales rose 1% to $28.9 billion, and product sales excluding Veklury rose 4% to $28.0 billion. Total revenues rose 2% to $29.4 billion. Source
  • Fourth-quarter revenue rose 5%: Fourth-quarter total revenues rose 5% to $7.9 billion, mainly from HIV and Liver Disease products, with lower Veklury sales partly offsetting. Source
  • Full-year GAAP EPS rose sharply: Full-year diluted EPS was $6.78, up from $0.38, driven mainly by lower acquired IPR&D expenses and lower IPR&D impairments, plus higher revenues and lower SG&A. Source
  • Non-GAAP EPS rose 77%: Full-year non-GAAP diluted EPS was $8.15, up from $4.62, primarily on lower acquired IPR&D expenses, higher revenues and lower SG&A expenses. Source
  • Fourth-quarter non-GAAP EPS eased: Fourth-quarter non-GAAP diluted EPS was $1.86, down from $1.90, mainly because of higher acquired IPR&D expenses. Source

Segments and regions

  • HIV sales grew on demand: Full-year HIV product sales rose 6% to $20.8 billion, driven by demand for HIV treatment and prevention. Source
  • Liver Disease rose on Livdelzi: Full-year Liver Disease sales rose 6% to $3.2 billion, mainly on Livdelzi and hepatitis B and D products, partly offset by lower hepatitis C prices. Source
  • Regional product sales broadly flat: Full-year U.S. product sales were $20.8 billion against $20.5 billion. Europe was $4.6 billion against $4.6 billion, and Rest of World was $3.5 billion against $3.5 billion. Source

“In 2026, our potential new launches include two cancer therapies and an additional HIV treatment option, and we look forward to building on the launches of Yeztugo and Livdelzi for liver disease.”

Daniel O’Day, Gilead’s Chairman and Chief Executive Officer

Products and customers

  • Descovy grew on demand and price: Full-year Descovy sales rose 31% to $2.8 billion, on higher demand and higher average realized price. Source
  • Cell Therapy sales declined: Full-year Cell Therapy sales fell 7% to $1.8 billion. Yescarta fell 5% to $1.5 billion and Tecartus fell 15% to $344 million, both on competition. Source
  • Trodelvy grew despite bladder withdrawal: Full-year Trodelvy sales rose 6% to $1.4 billion on breast cancer demand, partly offset by withdrawal of the bladder cancer indication. Source
  • Veklury sales fell by half: Full-year Veklury sales fell 49% to $911 million, mainly on fewer COVID-19-related hospitalizations. Source
  • Yeztugo launched in the U.S.: The company reported the U.S. launch of Yeztugo, described as the first twice-yearly HIV prevention therapy, as part of the year's results. Source

Costs, margins and pricing

  • Product gross margin held flat: Full-year product gross margin was 78.4%, against 78.2%. Non-GAAP product gross margin was 86.4%, against 86.2%. Source
  • SG&A fell on legal and corporate costs: Full-year SG&A was $5.8 billion against $6.1 billion, mainly on lower corporate, legal, integration and restructuring expenses, partly offset by higher HIV promotion. Source
  • R&D spend slightly lower: Full-year R&D expenses were $5.8 billion against $5.9 billion. Non-GAAP R&D was $5.7 billion, down on lower study-related and clinical manufacturing costs. Source
  • Acquired IPR&D fell from $4.7 billion: Full-year acquired IPR&D expenses were $1.0 billion, from the Interius acquisition and collaborations with LEO Pharma and Pregene, against $4.7 billion in 2024. Source
  • Full-year tax rate fell: Full-year effective tax rate was 13.1%, against 30.5%. Non-GAAP effective tax rate was 18.3%, against 25.9%, after a non-deductible CymaBay charge in the prior year. Source

Capital, cash and shareholder returns

  • Free cash flow for the year: Full-year free cash flow was $9.5 billion, against $10.3 billion in 2024. Operating cash flow was $10.0 billion, against $10.8 billion. Source
  • Cash balance rose: Cash, cash equivalents and marketable debt securities were $10.6 billion at December 31, 2025, up from $10.0 billion a year earlier. Source
  • Fourth-quarter dividends and buybacks: In the fourth quarter Gilead paid $1.0 billion in dividends and repurchased $230 million of common stock. Source
  • Quarterly dividend raised to $0.82: The Board declared a $0.82 quarterly dividend for Q1 2026, up from the $0.79 declared for Q4 2025. Source

Pipeline and clinical updates

  • BIC/LEN met Phase 3 endpoints: Phase 3 ARTISTRY-1 and ARTISTRY-2 trials of daily oral bictegravir and lenacapavir met primary endpoints against baseline regimens and against Biktarvy. Source
  • ASCENT-07 did not meet endpoint: Phase 3 ASCENT-07 trial of Trodelvy in first-line metastatic breast cancer did not meet its progression-free survival primary endpoint. Overall survival was not yet mature, with an early favorable trend. Source
  • STAR-221 study discontinued: The Phase 3 STAR-221 study was discontinued after an interim analysis, on the recommendation of the Independent Data Monitoring Committee. The Phase 2 EDGE-Gastric study will also be discontinued. Source
  • Cell therapy data presented at ASH: New positive data were presented with partner Arcellx from the Phase 2 iMMagine-1 trial, along with Phase 1 data for two bicistronic CAR T-cell therapies. Source

Corporate, labels and leadership

  • New General Counsel appointed: Keeley Cain Wettan was appointed Executive Vice President, General Counsel, Legal and Compliance. Source
  • U.S. government drug-cost agreement: Gilead announced an agreement with the U.S. government to lower the cost of medicines for Americans. The release gives no financial terms. Source
  • Yescarta label limitation removed: A new Yescarta label update removes a limitation around Primary Central Nervous System Lymphoma, for an ultra-rare cancer. Source

Coming up, as management said on 10 February 2026

  • Quarterly dividend payment: The $0.82 dividend is payable on March 30, 2026, to holders of record at the close of business on March 13, 2026. Source

Figures management reported

FigureReported
Biktarvy product sales, full year 2025 Source$14.3 billion
R&D expenses, full year 2025 Source$5.8 billion
Phase 3 trial readout SourceARTISTRY-1 and ARTISTRY-2 met primary endpoints

Risks management discussed

  • Demand: Cell Therapy sales fell in the fourth quarter on ongoing competitive headwinds. Source
  • Demand: Veklury sales fell in the fourth quarter as COVID-19-related hospitalizations declined. Source
  • External: Biktarvy sales were partly offset by lower average realized price. Source
  • Regulatory: The agreement with the U.S. government to lower medicine costs was announced without stated financial terms. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.