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SR One Capital Management, LP

CIK 1910264 · latest 13F filed 12 August 2026 · Read the filing on EDGAR

SR One Capital Management, LP reported 15 US-listed holdings worth $1.04 billion in its 13F for the quarter ended 30 June 2026, filed 12 August 2026. Its largest: Veradermics Inc (28.4%), Zenas Biopharma Inc. (12.3%) and Crispr Therapeutics AG (10.7%). Against the quarter before, it opened 3 positions, added to 1, trimmed 0 and sold out of 2.

Reported holdings$1.04B+13.5% on Q1 2026
Positions15+1 on Q1 2026
The largest ten95.1%of its reported holdings
Latest 13FQ2 2026filed 12 August 2026
Where the money is
OpenedAdded toHeld
MANE28.4%ZBIO12.3%CRSP10.7%AVLN10.5%DSGN9.1%ODTX6.8%ALMS5.3%ORIC4.8%MLYS4.1%SPRY3.1%MOBI2.6%NKTX0.9%OCS0.9%RARE

The 14 largest of its 15 positions, each sized by its share of the reported holdings, coloured by the change in shares against Q1 2026.

Reported holdings, quarter by quarter
Q3 2024: $498.7 million in 11 positions$499MQ3 24Q4 2024: $410.1 million in 11 positions$410MQ4 24Q1 2025: $389.3 million in 12 positions$389MQ1 25Q2 2025: $461.4 million in 13 positions$461MQ2 25Q3 2025: $691.4 million in 12 positions$691MQ3 25Q4 2025: $706.4 million in 13 positions$706MQ4 25Q1 2026: $915.4 million in 14 positions$915MQ1 26Q2 2026: $1.04 billion in 15 positions$1.04BQ2 26

What the fund reported holding at each quarter's end; hover a bar for the number of positions

What it did on the quarter

Opened 3Added 1Held 11Sold out 2
Opened: 3Added: 1Held: 11Sold out: 2

Its positions against its 13F for the quarter to 31 March 2026; a change under 0.1% of a position counts as held

Opened 3

  1. Avalyn Pharma Inc. AVLN$108.9 million
  2. Odyssey Therapeutics, Inc. ODTX$71.0 million
  3. Mobia Med Inc. MOBI$26.6 million

Added to 1

  1. Oric Pharmaceuticals Inc. ORIC+100,455 shares · +2%

Sold out of 2

  1. Arcellx Inc. ACLX$269.4 million last quarter
  2. Oruka Therapeutics Inc. ORKA$21.1 million last quarter

What it holds

CompanySharesValueOf its bookChange in shares
Veradermics Inc MANE2,401,868$295.3 million28.42%no change
Zenas Biopharma Inc. ZBIO5,037,854$127.9 million12.31%no change
Crispr Therapeutics AG CRSP2,038,763$111.2 million10.70%no change
Avalyn Pharma Inc. AVLN3,308,649$108.9 million10.48%new
Design Therapeutics Inc. DSGN6,526,476$94.4 million9.09%no change
Odyssey Therapeutics, Inc. ODTX3,794,883$71.0 million6.83%new
Alumis Inc. ALMS1,959,896$55.2 million5.31%no change
Oric Pharmaceuticals Inc. ORIC4,615,384$50.0 million4.81%+100,455
Mineralys Therapeutics Inc. MLYS1,563,966$42.2 million4.06%no change
Ars Pharmaceuticals Inc. SPRY4,012,903$32.1 million3.09%no change
Mobia Med Inc. MOBI1,986,072$26.6 million2.56%new
Nkarta Inc. NKTX3,333,333$9.4 million0.91%no change
Oculis Holding AG OCS641,022$8.9 million0.86%no change
Ultragenyx Pharmaceutical in RARE137,753$4.6 million0.44%no change
Engene Holdings Inc. ENGN747,750$1.3 million0.12%no change
Every US-listed position in the fund's 13F for the quarter ended 30 June 2026, by the value it reported.
Read moreChange is shares against its 13F for the quarter before; the 2 it sold out of are in the box above.