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Bristol-Myers Squibb Co.: Q2 FY2026 earnings call

What management said about Q2 FY2026, from the documents filed with the SEC on 30 July 2026: press release. Guidance figures: 4 raised, 3 kept. The quarter’s numbers.

Key takeaways

  • Revenue rose 6% to $13.0 billion: Total revenues were $13.0 billion, up 6% (5% Ex-FX), against $12.3 billion in the second quarter of 2025. Source
  • Growth Portfolio drove the gain: Management named Opdivo Qvantig, Reblozyl, Camzyos, Breyanzi and Opdualag as the main drivers of Growth Portfolio revenue growth. Source
  • Legacy Portfolio declined 4%: Legacy Portfolio revenue was $5.4 billion, down 4% (5% Ex-FX), as Eliquis demand gains were more than offset by generic impacts elsewhere in the portfolio. Source
  • Eliquis led Legacy Portfolio sales: Eliquis worldwide revenue was $4.5 billion, up 22% (21% Ex-FX), with U.S. up 27% and international up 9%. Source
  • Gross margin fell on product mix: Gross margin was 71.3% GAAP and 71.4% non-GAAP, against 72.5% and 72.6% a year earlier. Management attributes the decline to product mix. Source
  • Mezigdomide Phase 3 PFS improvement: Phase 3 SUCCESSOR-2 showed mezigdomide with carfilzomib and dexamethasone improved PFS versus carfilzomib and dexamethasone alone in relapsed or refractory multiple myeloma. Source
  • Hengrui deal covers 13 programs: Hengrui Pharma agreements advance 13 early-stage programs in oncology, hematology and immunology, aimed at faster early-stage clinical development. Source
  • Net debt position fell: Net debt position was $31.7 billion at June 30, 2026, against $34.0 billion at December 31, 2025. Source

“The Growth Portfolio continues to deliver, achieving 15% growth in the quarter, and represents an expanding share of our overall business,”

Christopher Boerner, Ph.D., board chair and chief executive officer, Bristol Myers Squibb

Guidance

AreaPeriodFigureAgainst last quarter
Total revenues (non-GAAP, reported and ex-FX) Sourcefull year 2026~$49.0 - $50.0 billionRaised from ~$46.0 - $47.5 billion
Gross margin % Sourcefull year 2026~69% - 70%Kept
Operating expenses (SG&A and R&D) Sourcefull year 2026~$16.5 billionRaised from ~$16.3 billion
Other income/(expense) Sourcefull year 2026~($700 million)Kept
Effective tax rate Sourcefull year 2026~18%Kept
Diluted EPS (non-GAAP) Sourcefull year 2026$6.75 - $7.00Raised from $6.05 - $6.35
Worldwide Eliquis revenue growth vs. 2025 Sourcefull year 202620% - 25%Raised from 10% - 15%

What changed from last quarter

  • Guidance raised: Full-year revenue guidance raised to about $49.0-50.0 billion from about $46.0-47.5 billion. Source
  • Guidance raised: Non-GAAP diluted EPS guidance raised to $6.75-$7.00 from $6.05-$6.35. Source
  • Guidance raised: Operating expense guidance raised to about $16.5 billion from about $16.3 billion. Source
  • Guidance raised: Worldwide Eliquis revenue growth guidance raised to 20%-25% from 10%-15%. Source
  • New: Collaboration with NVIDIA expanded in July 2026 to deploy Vera Rubin NVL72 AI infrastructure. Source
  • New: Strategic agreement with Anthropic to deploy Claude across research, clinical, manufacturing, commercial and corporate functions. Source
  • New: Collaboration and licensing agreements with Hengrui Pharma covering 13 early-stage programs. Source

Results and growth drivers

  • Revenue rose 6% to $13.0 billion: Total revenues were $13.0 billion, up 6% (5% Ex-FX), against $12.3 billion in the second quarter of 2025. Source
  • Growth Portfolio drove the gain: Management named Opdivo Qvantig, Reblozyl, Camzyos, Breyanzi and Opdualag as the main drivers of Growth Portfolio revenue growth. Source
  • Non-GAAP EPS rose to $2.04: Non-GAAP net income was $4.2 billion, or $2.04 per share, up 40% from $1.46. GAAP EPS was $1.62, against $0.64 a year earlier. Source
  • IPRD swing lifted per-share results: Acquired IPRD charges and licensing income added $0.01 to EPS in the second quarter, against a $0.57 reduction a year earlier. Source

Segments and regions

  • Growth Portfolio up 15%: Growth Portfolio revenue reached $7.6 billion, up 15% (14% Ex-FX). Source
  • Legacy Portfolio declined 4%: Legacy Portfolio revenue was $5.4 billion, down 4% (5% Ex-FX), as Eliquis demand gains were more than offset by generic impacts elsewhere in the portfolio. Source
  • U.S. and international both grew: U.S. revenue was $9.0 billion, up 6%. International revenue was $4.0 billion, up 6% (5% Ex-FX). Source

“As a result of our consistent execution and continued momentum, we are raising our 2026 full-year outlook.”

Christopher Boerner, Ph.D., board chair and chief executive officer, Bristol Myers Squibb

Product sales by brand

  • Eliquis led Legacy Portfolio sales: Eliquis worldwide revenue was $4.5 billion, up 22% (21% Ex-FX), with U.S. up 27% and international up 9%. Source
  • Opdivo Qvantig revenue up over 200%: Opdivo Qvantig revenue reached $261 million, with U.S. and international revenue each up more than 200%. Source
  • Reblozyl revenue grew 29%: Reblozyl revenue was $735 million, up 29%, with U.S. up 31% and international up 24%. Source
  • Camzyos and Breyanzi grew: Camzyos revenue reached $416 million, up 60%, and Breyanzi revenue reached $484 million, up 41%. Source
  • Opdivo sales declined: Opdivo revenue was $2.5 billion, down 3% (4% Ex-FX), with U.S. revenue down 6%. Source
  • Pomalyst revenue fell sharply: Pomalyst/Imnovid revenue was $204 million, down 71%, with U.S. revenue down 78%. Source

Costs and margins

  • Gross margin fell on product mix: Gross margin was 71.3% GAAP and 71.4% non-GAAP, against 72.5% and 72.6% a year earlier. Management attributes the decline to product mix. Source
  • SG&A rose on launch spending: SG&A was $1.8 billion, up 7% GAAP and 8% non-GAAP, driven by investments in new product launches. Source
  • Non-GAAP R&D rose 2%: Non-GAAP R&D expense was $2.3 billion, up 2%, excluding specified items. Source
  • Amortization fell on Pomalyst: Amortization of acquired intangible assets was $437 million, down 47%, mainly from lower amortization related to Pomalyst. Source
  • Tax rate rose on non-GAAP basis: Non-GAAP effective tax rate was 16.5%, up from 16.1%, on jurisdictional earnings mix. GAAP rate was 18.8%, down from 25.9%. Source

“We are building from a position of strength and progressing a differentiated pipeline designed to generate long-term value.”

Christopher Boerner, Ph.D., board chair and chief executive officer, Bristol Myers Squibb

Pipeline and regulatory milestones

  • Opdivo approved in EU for Hodgkin: The European Commission approved Opdivo with doxorubicin, vinblastine and dacarbazine for previously untreated Stage III or IV classical Hodgkin Lymphoma, announced June 1. Source
  • Sotyktu approved in EU for PsA: The European Commission approved Sotyktu, alone or with methotrexate, for psoriatic arthritis in adults with inadequate response or intolerance to a prior therapy, announced May 8. Source
  • Mezigdomide Phase 3 PFS improvement: Phase 3 SUCCESSOR-2 showed mezigdomide with carfilzomib and dexamethasone improved PFS versus carfilzomib and dexamethasone alone in relapsed or refractory multiple myeloma. Source
  • Iza-bren interim Phase 3 results: Partner Sichuan Biokin reported interim Phase 3 results for iza-bren in two studies, covering triple-negative breast cancer and esophageal squamous cell carcinoma. Source
  • Pumitamig Phase 2 response rates: Interim Phase 2 data from the ROSETTA Lung-02 trial, announced with BioNTech, showed high response rates in non-squamous and squamous NSCLC. Source

Strategy and business development

  • Three priorities guide strategy: Management lists focusing R&D on high-impact medicines, embedding operational execution in the Growth Portfolio, and maintaining disciplined capital allocation. Source
  • Hengrui deal covers 13 programs: Hengrui Pharma agreements advance 13 early-stage programs in oncology, hematology and immunology, aimed at faster early-stage clinical development. Source
  • Anthropic agreement across functions: Claude will be deployed across research, clinical development, manufacturing, commercial and corporate functions as a shared intelligence platform. Source
  • NVIDIA AI infrastructure expansion: Expanded NVIDIA collaboration to run predictive models and train large AI models on company data, with the aim of earlier decisions on programs. Source

Balance sheet and capital

  • Cash and securities rose slightly: Cash, cash equivalents and marketable debt securities were $11.5 billion at June 30, 2026, against $11.1 billion at December 31, 2025. Source
  • Debt obligations declined: Short-term debt obligations were $1.0 billion, down from $2.3 billion. Long-term debt was $42.1 billion, down from $42.9 billion. Source
  • Net debt position fell: Net debt position was $31.7 billion at June 30, 2026, against $34.0 billion at December 31, 2025. Source
  • Diluted share count edged up: Diluted weighted-average shares were 2,048 million in the second quarter, against 2,038 million a year earlier. Source

Coming up, as management said on 30 July 2026

  • Iberdomide FDA action date: FDA PDUFA date for iberdomide is August 17, 2026. Source
  • Camzyos adolescent review under way: FDA accepted the Camzyos adolescent sNDA for priority review; no action date is given in the release. Source
  • Reblozyl FDA action date: FDA set a PDUFA date of March 11, 2027 for the Reblozyl supplemental application with JAK inhibitor therapy in myelofibrosis-associated anemia. Source
  • Mezigdomide FDA action date: FDA accepted the mezigdomide New Drug Application with a PDUFA date of May 13, 2027. Source

Figures management reported

FigureReported
Eliquis worldwide revenue, Q2 2026 Source$4,481 million, up 22%
Growth Portfolio revenue, Q2 2026 Source$7,560 million, up 15%
Revlimid worldwide revenue, Q2 2026 Source$425 million, down 49%
Non-GAAP R&D expense, Q2 2026 Source$2,316 million, up 2%
Mezigdomide PFS risk reduction vs. Kd Source52%

Risks management discussed

  • Demand: Management expects continued generic impacts across the rest of the Legacy Portfolio, which more than offset Eliquis demand growth. Source
  • Financial: GAAP R&D rose on a priority review voucher purchase and higher IPRD impairment charges, which the company excludes from non-GAAP results. Source
  • Financial: Other income declined because royalty income on diabetes products expired at the end of 2025. Source

Earlier plans management reported on

  • Not stated: Management continues to expect Eliquis revenue to rise in 2026 versus 2025, and raised the projected growth range. Source
  • Not stated: Management ties its three priorities to the multi-year strategy for long-term growth. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.