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Repligen Corp.: Q4 FY2025 earnings call

What management said about Q4 FY2025, from the documents filed with the SEC on 24 February 2026: press release. Guidance figures: 12 new. The quarter’s numbers.

Key takeaways

  • Q4 revenue up 18%, organic 14%: Fourth quarter revenue was $198 million, up 18% as reported and 14% organic. Full year 2025 revenue was $738 million, up 16% as reported and 14% organic. Source
  • Exceeded high end of October guidance: Management said revenue and adjusted operating income exceeded the high end of October guidance. That October revenue guidance was $729M to $737M, per the third quarter release. Source
  • First full-year 2026 guidance issued: Management called the 10% to 14% revenue growth guidance an appropriate starting point for the year. The guidance covers the existing business and excludes pending acquisitions. Source
  • Operating margin to expand 150 bps: Management expects adjusted operating margin to expand by 150 bps at the midpoint of 2026 guidance. Source
  • Three high-performance resins launched: The launches were two AVIPure HiPer affinity resins, for AAV9 and AAV8, and a HiPer QA anion exchange resin, extending the proteins portfolio. Source
  • Adjusted operating margin up in Q4 and FY: Adjusted operating margin was 15.0% in Q4 2025 against 14.9% a year earlier, and 13.8% for FY2025 against 12.9%. The full-year gain was 90 bps, or 240 bps excluding M&A and foreign exchange. Source
  • Continued order momentum in Q4: Management cited continued momentum in orders during the quarter alongside 14% organic revenue growth. The release gives no order volumes or order values. Source

“We had a great finish to 2025 with 14% organic growth in the quarter led by Analytics and Proteins.”

Olivier Loeillot, President and Chief Executive Officer of Repligen

Guidance

AreaPeriodFigureAgainst last quarter
Total reported revenue SourceFY2026$810M - $840MNew
Reported revenue growth SourceFY202610% - 14%New
Organic revenue growth SourceFY20269% - 13%New
Gross margin (adjusted) SourceFY202653.6% - 54.1%New
Income from operations (adjusted) SourceFY2026$122M - $130MNew
Operating margin (adjusted) SourceFY202615.1% - 15.5%New
Other income (expense) SourceFY2026~$18MNew
Adjusted EBITDA margin SourceFY202620% - 20.5%New
Tax rate on pre-tax income SourceFY202622% - 23%New
Net income (adjusted) SourceFY2026$109M - $114MNew
Diluted EPS (adjusted) SourceFY2026$1.93 - $2.01New
Adjusted operating margin expansion SourceFY2026, at midpoint150 bpsNew

What changed from last quarter

  • New guidance: The company issued full-year 2026 financial guidance with this release. Source
  • New: The company opened a new office in Singapore and expanded its footprint in Japan during the fourth quarter. Source

Fourth quarter and full year results

  • Q4 revenue up 18%, organic 14%: Fourth quarter revenue was $198 million, up 18% as reported and 14% organic. Full year 2025 revenue was $738 million, up 16% as reported and 14% organic. Source
  • Exceeded high end of October guidance: Management said revenue and adjusted operating income exceeded the high end of October guidance. That October revenue guidance was $729M to $737M, per the third quarter release. Source
  • Full year adjusted EPS $1.71: Full year 2025 GAAP diluted EPS was $0.86, against a loss of $0.46 a year earlier. Adjusted diluted EPS was $1.71, compared with $1.58. Source

2026 guidance and assumptions

  • First full-year 2026 guidance issued: Management called the 10% to 14% revenue growth guidance an appropriate starting point for the year. The guidance covers the existing business and excludes pending acquisitions. Source
  • Operating margin to expand 150 bps: Management expects adjusted operating margin to expand by 150 bps at the midpoint of 2026 guidance. Source
  • Just under one point from FX and M&A: Revenue guidance includes just under one point of benefit from foreign currency and M&A, according to the release. Source

“As we turn the page to 2026, we are excited about our product portfolio, the team we've built, and the strategy we are executing.”

Olivier Loeillot, President and Chief Executive Officer of Repligen

Franchises, regions and products

  • Analytics expanded by M&A and launches: Management said the company expanded its Analytics portfolio through M&A and launched multiple new products across Analytics, Filtration and Proteins. Source
  • Three high-performance resins launched: The launches were two AVIPure HiPer affinity resins, for AAV9 and AAV8, and a HiPer QA anion exchange resin, extending the proteins portfolio. Source

Margins and costs

  • Adjusted operating margin up in Q4 and FY: Adjusted operating margin was 15.0% in Q4 2025 against 14.9% a year earlier, and 13.8% for FY2025 against 12.9%. The full-year gain was 90 bps, or 240 bps excluding M&A and foreign exchange. Source
  • Adjusted gross margin 52.4% in Q4: Adjusted gross margin was 52.4% in Q4 2025 against 50.7%, and 52.6% for FY2025 against 50.4% a year earlier. Source
  • Restructuring inventory benefit in cost of goods: GAAP gross margin was 52.5% in Q4 against 23.2% a year earlier. Cost of goods sold included a $1.7M benefit in Q4 and $5.0M for FY2025 from sale of reserved restructuring inventory. Source
  • Adjusted SG&A rose year over year: Adjusted SG&A was $61.8M in Q4 2025 against $48.5M, and $237.2M for FY2025 against $195.6M. Source

“We remain focused on innovation that enables customers to accelerate development and improve yields.”

Olivier Loeillot, President and Chief Executive Officer of Repligen

Demand and orders

  • Continued order momentum in Q4: Management cited continued momentum in orders during the quarter alongside 14% organic revenue growth. The release gives no order volumes or order values. Source
  • FY organic non-COVID growth 16%: Management said FY2025 organic non-COVID growth was 16%, driven by traction across the differentiated portfolio. Source

Cash, balance sheet and capital

  • Cash and securities rose to $768M: Cash, equivalents and marketable securities were $768M at year end, up from $757M. Cash and equivalents were $566M, with $201.6M held in marketable securities. Source
  • Operating cash flow lower in 2025: Cash provided by operating activities was $117.4M for FY2025, against $175.4M for FY2024. Source
  • Acquisitions and securities purchases: FY2025 acquisitions used $70.3M net of cash acquired. Purchases of marketable securities were $200.3M. Source

Strategy and investment

  • Investing in commercial presence and scale: Management said the company is investing in its commercial presence and scaling operations for greater agility. The release gives no amounts for this investment. Source
  • Singapore office and Japan footprint: In Q4 the company opened an office in Singapore and expanded its Japan footprint, adding to its Asia Pacific presence. Source

Coming up, as management said on 24 February 2026

  • Continued Asia Pacific investment: Management said it will continue investing in the Asia Pacific region to support future growth. Source

Figures management reported

FigureReported
R&D expense (GAAP) Source$13,120 thousand in Q4 2025 and $54,177 thousand for FY2025, against $11,677 thousand and $43,200 thousand a year earlier

Risks management discussed

  • Demand: Management said the 2026 guidance includes a two-point headwind from gene therapy, which lowers the growth range. Source
  • External: Guidance excludes future currency fluctuations and any potential or pending acquisitions, so the guided figures do not reflect those changes. Source

Earlier plans management reported on

  • Met: Management said the company executed on all 2025 strategic priorities, with 14% organic growth in FY25. Source
  • Ahead: Management said FY25 organic growth surpassed the high end of the initial guidance range. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.