Open the filing on EDGARNovocure Reports Third Quarter 2026 Financial Results and Raises 2026 Guidance
Third quarter net revenues of $193 million an increase of 16% year-over-year, driven by 19% growth in active patients worldwide
Strong performance drove increased net revenue guidance for full-year 2026 to $736 million - $743 million and adjusted EBITDA guidance to $24 million - $34 million
Optune Pax® approved by Japan's Ministry of Health, Labour and Welfare for the treatment of locally advanced pancreatic cancer
BAAR, Switzerland - October 29, 2026 - Novocure (Nasdaq: NVCR) today reported financial results for the third quarter that ended September 30, 2026. Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer by developing and commercializing its innovative therapy, Tumor Treating Fields (TTFields).
“Novocure’s strong third quarter performance was driven by continued growth in our Optune Gio business and our growing portfolio of products launching in new markets, resulting in a record number of active patients on our therapies,” said Frank Leonard, CEO, Novocure. “We achieved record-high quarterly net revenue and are well-positioned to achieve the commercial, clinical and financial goals we set out in January. Based on the results from this quarter, we have raised our financial guidance for 2026 and will continue to build on the strong progress we have made on our path to profitability.”
Financial updates for the quarter ended September 30, 2026:
- Total net revenues for the quarter were $193.4 million, an increase of 16% compared to the same period in 2025. This increase was primarily driven by 19% global active patient growth.
- The U.S., Germany, France and Japan contributed $111.9 million, $24.9 million, $18.7 million and $14.5 million, respectively, with other active markets contributing $18.8 million.
- $4.4 million in net revenue recognized from one-time benefits in the U.S. and Germany related to increases in claims approval rates.
- Net revenue from Optune Lua® and Optune Pax® in the quarter was $11.9 million.
- Recognized revenue from Optune Lua in the quarter was $8.2 million. The U.S., Germany and Japan contributed $2.3 million, $1.8 million and $4.1 million, respectively.
- Recognized revenue from Optune Pax in the quarter was $3.7 million, substantially all from sales in the U.S.
- Revenue in Greater China from Novocure’s partnership with Zai Lab totaled $4.5 million.
- Gross margin for the quarter was 77% compared to 73% in the prior year. This improvement was primarily driven by higher net revenue primarily attributable to higher active patient volumes in conjunction with lower cost of revenues per active patient, driven primarily by improved array utilization and manufacturing efficiencies.
- Research, development and clinical study expenses for the quarter were $58.1 million, an increase of 8% from the same period in 2025. This increase was primarily driven by an increase in clinical trial expenses mostly attributable to KEYNOTE D58.
- Sales and marketing expenses for the quarter were $53.3 million, a decrease of 9% compared to the same period in 2025. This decrease was primarily driven by lower share-based compensation expenses and lower marketing expenses.
- General and administrative expenses for the quarter were $43.6 million, a decrease of 5% compared to the same period in 2025. This decrease was primarily driven by lower share-based compensation expenses.
- Net loss for the quarter was $10.4 million with loss per share of $0.09.
- Adjusted EBITDA* for the quarter was $15.7 million.
- Cash, cash equivalents and short-term investments were $463.5 million as of September 30, 2026.
Operational updates for the quarter ended September 30, 2026:
- As of September 30, 2026, there were 5,260 total active patients on TTFields therapy globally.
- Optune Gio
- As of September 30, 2026, there were 4,729 active patients on Optune Gio, an increase of 11% from the same period in 2025.
- The U.S., Germany, France and Japan contributed 2,324; 656; 493 and 592 active patients, respectively, with 664 active patients contributed by other active markets.
- Optune Lua
- As of September 30, 2026, there were 255 active patients on Optune Lua, an increase of 83% from the same period in 2025.
- The U.S., Germany, France and Japan contributed 97; 42; 1 and 110 active patients, respectively, with 5 active patients contributed by other active markets.
- Optune Pax
- 238 prescriptions for Optune Pax were received in the quarter. The U.S. and Germany contributed 209 and 29 prescriptions, respectively.
- As of September 30, 2026, there were 276 active patients on Optune Pax. The U.S. and Germany contributed 266 and 10 active patients, respectively.
Quarterly updates and recent achievements:
- October 2026
- Optune Pax received approval from Japan's Ministry of Health, Labour and Welfare (MHLW) for the treatment of adult patients diagnosed with
unresectable locally advanced pancreatic cancer, concomitant with gemcitabine and nab-paclitaxel.
- Novocure entered into a clinical trial collaboration and supply agreement with Verastem Oncology to evaluate the use of TTFields therapy with chemotherapy and VS-7375, Verastem’s investigational oral, potent and selective KRAS G12D (ON/OFF) inhibitor, to treat locally advanced pancreatic cancer.
2026 Financial Guidance:
Novocure’s updated guidance for the full year 2026, as of October 29, 2026, is summarized below:
- Total net revenue: $736 million - $743 million (previous: $710 million - $725 million)
- Adjusted EBITDA*: $24 million - $34 million (previous: $0 million - $15 million)
This guidance assumes full-year mid-to-high single digit net revenue growth from Optune Gio, net revenue contribution from Optune Lua and Optune Pax, collectively, between $30 million and $34 million, foreign exchange rates as of September 30, 2026, and quarterly gross margin in the mid-to-high 70s percent.
Anticipated clinical and regulatory milestones:
- Decision by the U.S. FDA on the premarket approval application for use of TTFields therapy for the treatment of brain metastases from non-small cell lung cancer (Q4 2026).
- Complete enrollment in Phase 3 KEYNOTE D58 clinical trial in newly diagnosed glioblastoma (Q4 2026).
Conference call details
Novocure will host a conference call and webcast to discuss third quarter 2026 financial results at 8:00 a.m. EDT today, Thursday, October 29, 2026. To access the conference call by phone, use the following conference call registration link and dial-in details will be provided. To access the webcast, use the following webcast registration link.
The webcast, earnings slides presented during the webcast and the corporate presentation can be accessed live from the Investor Relations page of Novocure’s website, investor.novocure.com, and will be available for at least 14 days following the call. Novocure has used, and intends to continue to use, its investor relations website, as a means of disclosing material non-public information and for complying with its disclosure obligations under Regulation FD.
About Novocure
Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure’s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma, pancreatic cancer, non-small cell lung cancer, malignant pleural mesothelioma and pleural mesothelioma. Novocure has several additional ongoing or completed clinical trials exploring the use of Tumor Treating Fields therapy in the treatment of glioblastoma, non-small cell lung cancer and pancreatic cancer.
Novocure’s global headquarters is located in Baar, Switzerland, with U.S. headquarters located in Portsmouth, New Hampshire and research and development facilities located in Haifa, Israel. For additional information about the company, please visit Novocure.com and follow @Novocure on LinkedIn and X.
*Non-GAAP Financial Measurements
We measure our performance based upon a non-U.S. GAAP measurement of earnings before interest, taxes, depreciation, amortization and shared-based compensation ("Adjusted EBITDA"). We believe Adjusted EBITDA is useful to investors in evaluating our operating performance because it helps investors compare the results of our operations from period to period by removing the impact of earnings attributable to our capital structure, tax rate and material non-cash items, specifically share-based compensation.
Forward-Looking Statements
Forward-looking statements notice
In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocure’s current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, clinical study progress, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, coverage, collections from third-party payers and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as “anticipate,” “estimate,” “expect,” “project,” “intend,” “plan,” “believe” or other words and terms of similar meaning. Novocure’s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, environmental, regulatory and political conditions and other more specific risks and uncertainties facing Novocure such as those set forth in its Annual Report on Form 10-K filed on February 26, 2026, and subsequent flings with the U.S. Securities and Exchange Commission. Given these risks and uncertainties, any or all of these forward-looking statements may prove to be incorrect. Therefore, you should not rely on any such factors or forward-looking statements. Furthermore, Novocure does not intend to update publicly any forward-looking statement, except as required by law. Any forward-looking statements herein speak only as of the date hereof. The Private Securities Litigation Reform Act of 1995 permits this discussion.
| Three months ended September 30, | Nine months ended September 30, | Year ended December 31, |
|---|
| 2026 | 2025 | 2026 | 2025 | 2025 |
|---|
| Unaudited | Unaudited | Audited |
|---|
| NOVOCURE LIMITED AND SUBSIDIARIES CONSOLIDATED STATEMENTS OF OPERATIONS |
| U.S. dollars in thousands (except share and per share data) |
| Net revenues | $193,399 | | $167,204 | | $551,038 | | $481,003 | | $655,353 | |
| Cost of revenues | 44,529 | | 44,729 | | 124,564 | | 124,722 | | 166,879 | |
| Gross profit | 148,870 | | 122,475 | | 426,474 | | 356,281 | | 488,474 | |
| Operating costs and expenses: | | | | | |
| Research, development and clinical studies | 58,099 | | 54,029 | | 167,883 | | 163,639 | | 224,544 | |
| Sales and marketing | 53,297 | | 58,546 | | 173,338 | | 171,404 | | 240,064 | |
| General and administrative | 43,645 | | 45,921 | | 169,406 | | 134,645 | | 177,666 | |
| Total operating costs and expenses | 155,041 | | 158,496 | | 510,627 | | 469,688 | | 642,274 | |
| Operating income (loss) | (6,171) | | (36,021) | | (84,153) | | (113,407) | | (153,800) | |
| Financial income (expenses), net | (1,709) | | 5,999 | | (5,437) | | 18,111 | | 17,550 | |
| Income (loss) before income tax | (7,880) | | (30,022) | | (89,590) | | (95,296) | | (136,250) | |
| Income tax | 2,555 | | 7,248 | | 7,641 | | 16,432 | | (23) | |
| Net income (loss) | $(10,435) | | $(37,270) | | $(97,231) | | $(111,728) | | $(136,227) | |
| Basic and diluted net income (loss) per ordinary share | $(0.09) | | $(0.33) | | $(0.84) | | $(1.00) | | $(1.22) | |
| Weighted average number of ordinary shares used in computing basic and diluted net income (loss) per share | 116,785,198 | | 111,908,252 | | 115,685,559 | | 111,259,532 | | 111,471,991 | |
Consolidated Balance Sheets
USD in thousands (except share data)
| September 30, 2026 | December 31, 2025 |
|---|
| Unaudited | Audited |
|---|
| NOVOCURE LIMITED AND SUBSIDIARIES CONSOLIDATED BALANCE SHEETS |
| U.S. dollars in thousands (except share data) |
| ASSETS | | |
| CURRENT ASSETS: | | |
| Cash and cash equivalents | $96,734 | $93,548 |
| Short-term investments | 366,745 | 354,126 |
| Restricted cash | 10,106 | 9,842 |
| Trade receivables, net | 108,260 | 89,435 |
| Receivables and prepaid expenses | 51,069 | 58,669 |
| Inventories | 40,605 | 41,111 |
| Total current assets | 673,519 | 646,731 |
| LONG-TERM ASSETS: | | |
| Property and equipment, net | 72,667 | 77,606 |
| Field equipment, net | 28,362 | 22,066 |
| Right-of-use assets | 43,063 | 47,327 |
| Other long-term assets | 11,097 | 10,596 |
| Total long-term assets | 155,189 | 157,595 |
| TOTAL ASSETS | $828,708 | $804,326 |
| LIABILITIES AND SHAREHOLDERS' EQUITY | | |
| CURRENT LIABILITIES: | | |
| Current maturity of senior secured credit facility | $25,000 | $ - |
| Trade payables | 145,918 | 122,231 |
| Other payables, lease liabilities and accrued expenses | 99,741 | 100,997 |
| Total current liabilities | 270,659 | 223,228 |
| LONG-TERM LIABILITIES: | | |
| Senior secured credit facility, net | 171,337 | 195,047 |
| Long-term leases | 35,217 | 41,647 |
| Employee benefit liabilities | 882 | 3,938 |
| Total long-term liabilities | 207,436 | 240,632 |
| TOTAL LIABILITIES | 478,095 | 463,860 |
| COMMITMENTS AND CONTINGENCIES | | |
| SHAREHOLDERS' EQUITY: | | |
| Share capital - | | |
| Ordinary shares no par value, Unlimited shares authorized; issued and outstanding:116,914,114 shares and 112,492,667 shares at September 30, 2026 (unaudited) and December 31, 2025, respectively | - | - |
| Additional paid-in capital | 1,739,793 | 1,634,264 |
| Accumulated other comprehensive income (loss) | (1,592) | (3,441) |
| Retained earnings (accumulated deficit) | (1,387,588) | (1,290,357) |
| TOTAL SHAREHOLDERS' EQUITY | 350,613 | 340,466 |
| TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY | $828,708 | $804,326 |
Non-U.S. GAAP Financial Measures Reconciliation
USD in thousands
| Three months ended September 30, | Nine months ended September 30, |
|---|
| 2026 | 2025 | % Change | 2026 | 2025 | % Change |
|---|
| Net income (loss) | $(10,435) | | $(37,270) | | (72)% | $(97,231) | | $(111,728) | | (13)% |
| Add: Income tax | 2,555 | | 7,248 | | (65)% | 7,641 | | 16,432 | | (53)% |
| Add: Financial expenses (income), net | 1,709 | | (5,999) | | (128)% | 5,437 | | (18,111) | | (130)% |
| Add: Depreciation and amortization | 4,416 | | 3,663 | | 21% | 12,847 | | 10,432 | | 23% |
| EBITDA | $(1,755) | | $(32,358) | | (95)% | $(71,306) | | $(102,975) | | (31)% |
| Add: Share-based compensation | 17,483 | | 29,321 | | (40)% | 97,504 | | 85,016 | | 15% |
| Adjusted EBITDA | $15,728 | | $(3,037) | | (618)% | $26,198 | | $(17,959) | | (246)% |
Active Patients at Period End
| September 30, |
|---|
| 2026 | 2025 |
|---|
| Optune Gio | Optune Lua | Optune Pax | Total | Optune Gio | Optune Lua | Optune Pax | Total |
|---|
| Active patients at period end | | | | | | | | |
| United States | 2,324 | 97 | 266 | 2,687 | | 2,176 | 104 | - | 2,280 | |
| International markets: | | | | | | | | |
| Germany | 656 | 42 | 10 | 708 | | 595 | 31 | - | 626 | |
| France | 493 | 1 | - | 494 | | 499 | - | - | 499 | |
| Japan | 592 | 110 | - | 702 | | 474 | - | - | 474 | |
| Other international | 664 | 5 | - | 669 | | 533 | 4 | - | 537 | |
| International markets - Total | 2,405 | 158 | 10 | 2,573 | | 2,101 | 35 | - | 2,136 | |
| 4,729 | 255 | 276 | 5,260 | | 4,277 | 139 | - | 4,416 | |
Indication and Important Safety Information for Optune Gio®
What is Optune Gio ® approved to treat?
Optune Gio is a wearable, portable, FDA-approved device indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.
Newly diagnosed GBM
If you have newly diagnosed GBM, Optune Gio is used together with a chemotherapy called temozolomide (TMZ) if:
- Your cancer is confirmed by your healthcare professional AND
- You have had surgery to remove as much of the tumor as possible
Recurrent GBM
If your tumor has come back, Optune Gio can be used alone as an alternative to standard medical therapy if:
- You have tried surgery and radiation and they did not work or are no longer working AND
- You have tried chemotherapy and your GBM has been confirmed by your healthcare professional
Who should not use Optune Gio?
Optune Gio is not for everyone. Talk to your doctor if you have:
- An implanted medical device (programmable shunt), skull defect (missing bone with no replacement), or bullet fragment. Optune Gio has not been tested in people with implanted electronic devices, which may cause the devices not to work properly, and Optune Gio has not been tested in people with skull defects or bullet fragments, which may cause Optune Gio not to work properly
- A known sensitivity to conductive hydrogels (the gel on the arrays placed on the scalp like the ones used on EKGs). When Optune Gio comes into contact with the skin, it may cause more redness and itching or may rarely cause a life-threatening allergic reaction
Do not use Optune Gio if you are pregnant or are planning to become pregnant. It is not known if Optune Gio is safe or effective during pregnancy.
What should I know before using Optune Gio?
Optune Gio should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune Gio.
- Do not use any parts that did not come with the Optune Gio Treatment Kit sent to you by Novocure or given to you by your doctor
- Do not get the device or transducer arrays wet
- If you have an underlying serious skin condition on the scalp, discuss with your doctor whether this may prevent or temporarily interfere with Optune Gio treatment
What are the possible side effects of Optune Gio?
Most common side effects of Optune Gio when used together with chemotherapy (temozolomide, or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression. The most common side effects when using Optune Gio alone were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers. Talk to your doctor if you have any of these side effects or questions.
Please visit OptuneGio.com for Instructions For Use (IFU) for complete information regarding the device’s indications, contraindications, warnings, and precautions.
Indication and Important Safety Information for Optune Lua®
What is Optune Lua ® approved to treat?
Optune Lua is a wearable, portable, FDA-approved device used together with PD-1/PD-L1 inhibitors (immunotherapy) or docetaxel. It is indicated for adult patients with metastatic non-small cell lung cancer (mNSCLC) who have progressed on or after a platinum-based regimen.
Who should not use Optune Lua?
Optune Lua for mNSCLC is not for everyone. Talk to your doctor if you have:
- An electrical implant. Use of Optune Lua together with electrical implants has not been tested and may cause the implanted device not to work properly
- A known sensitivity to gels like the gel used on electrocardiogram (ECG) stickers or transcutaneous electrical nerve stimulation (TENS) electrodes. In this case, skin contact with the gel used with Optune Lua may commonly cause increased redness and itching, and rarely may even lead to severe allergies such as a fall in blood pressure and difficulty breathing
- Do not use Optune Lua if you are pregnant or are planning to become pregnant. It is not known if Optune Lua is safe or effective during pregnancy.
What should I know before using Optune Lua?
Optune Lua should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune Lua.
- Do not use any parts that did not come with Optune Lua Treatment Kit sent to you by Novocure or given to you by your doctor
- Do not get the device or transducer arrays wet
- Please be aware that Optune Lua has a cord that plugs into an electrical socket. Be careful of tripping when it’s connected
- If you have an underlying serious skin condition where the transducer arrays are placed, discuss with your doctor whether this may prevent or temporarily interfere with Optune Lua treatment.
What are the possible side effects of Optune Lua?
The most common side effects of Optune Lua when used together with certain immunotherapy and chemotherapy drugs were dermatitis, pain in the muscles, bones, or joints, fatigue, anemia, alopecia (hair loss), dyspnea, nausea, cough, diarrhea, anorexia, pruritus (itching), leukopenia, pneumonia, respiratory tract infection, localized edema (swelling), rash, pain, constipation, skin ulcers, hypokalemia (low potassium levels), hypoalbuminemia (low albumin levels), hyponatremia (low sodium levels), and dysphagia (difficulty swallowing).
Other potential adverse effects associated with the use of Optune Lua include treatment related skin irritation, allergic reaction to the adhesive or to the gel, overheating of the array leading to pain and/or local skin burns, infections at site where the arrays make contact with the skin, local warmth and tingling sensation beneath the arrays, medical device site reaction, muscle twitching, and skin breakdown/skin ulcer. Talk to your doctor if you have any of these side effects or questions.
Please visit OptuneLua.com for Instructions For Use (IFU) for complete information regarding the device’s indications, contraindications, warnings, and precautions.
Indication and Important Safety Information for Optune Pax®
What is Optune Pax® approved to treat?
Optune Pax is an FDA-approved wearable therapeutic device, used together with gemcitabine and nab-paclitaxel (a chemotherapy combination). It is indicated for the treatment of adult patients with locally advanced pancreatic cancer.
Who should not use Optune Pax?
Optune Pax for locally advanced pancreatic cancer is not for everyone. Talk to your doctor if you have:
- An electrical implant. Use of Optune Pax together with electrical implants has not been tested and may cause the implanted device not to work properly.
- A known sensitivity to gels like the gel used on electrocardiogram (ECG) stickers or transcutaneous electrical nerve stimulation (TENS) electrodes. In this case, skin contact with the gel used with Optune Pax may commonly cause increased redness and itching. In rare cases, it may lead to severe allergic reactions that can cause a drop in blood pressure and difficulty breathing
- Do not use Optune Pax if you are pregnant or are planning to become pregnant. If you are a woman who is able to get pregnant, you must use birth control when using the device. It is not known if Optune Pax is safe or effective during pregnancy.
What should I know before using Optune Pax?
Optune Pax should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune Pax.
- Do not use any parts that did not come with the Optune Pax Treatment Kit sent to you by Novocure or given to you by your doctor
- Do not get the device or transducer arrays wet
- Please be aware that Optune Pax has a cord that plugs into an electrical socket. Be careful of tripping when it's connected
- If you have an underlying skin condition where the transducer arrays are placed, discuss with your doctor whether this may prevent or temporarily interfere with Optune Pax treatment
What are the possible side effects of Optune Pax?
The most common side effects of Optune Pax used together with chemotherapy drugs were low neutrophils, low red blood cell count, low platelet count, low white blood cell count, diarrhea, nausea, vomiting, abdominal pain, constipation, fatigue, swelling, fever, pain, COVID-19, infection, respiratory tract infection, urinary tract infection, pneumonia, liver enzyme increased, weight loss, low potassium level, low albumin level, high blood sugar, muscle pain, neuropathy peripheral (damage to the nerves outside the brain and spinal cord), taste disorder, dizziness, difficulty sleeping, shortness of breath, hair loss, skin-related disorders, and low blood pressure.
Device-related skin adverse effects associated with the use of Optune Pax include skin inflammation, rash, itching, skin redness, skin irritation, skin infection, heavy sweating, and open sores. Other device-related adverse effects associated with the use of Optune Pax include overheating of the array, leading to pain and/or local skin burns, allergic reaction to the adhesive or gel from the transducer arrays, and local warmth and tingling sensation beneath the arrays. Talk to your doctor if you have any of these side effects or have any questions.
Please visit OptunePax.com for Instructions For Use (IFU) for complete information regarding the device’s indications, contraindications, warnings, and precautions.
Contacts
Adam Daney investorinfo@novocure.com
Catherine Falcetti media@novocure.com