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Acadia Pharmaceuticals Inc.: Q4 FY2025 earnings call

What management said about Q4 FY2025, from the documents filed with the SEC on 25 February 2026: press release. The quarter’s numbers.

Key takeaways

  • Revenue grew on GAAP and adjusted bases: GAAP total revenues were $284 million in the fourth quarter of 2025, up 9%, and $1.07 billion for the full year, up 12%. Non-GAAP adjusted total revenues were $298 million for the quarter, up 16%, and $1.08 billion for the year, up 14%. Source
  • NUPLAZID adjusted quarterly sales rose 17%: Non-GAAP adjusted NUPLAZID net sales were $189 million in the fourth quarter, up 17% from $161 million. GAAP net sales for the quarter were $174 million. Source
  • Volume rose 9% for year, 13% in quarter: NUPLAZID volume grew 9% over the full year 2025 and 13% in the fourth quarter. The company stated the GAAP accounting adjustment does not reflect this underlying commercial performance. Source
  • IRA rebate estimate raised $20 million: The company recorded a $20 million change in estimate to NUPLAZID IRA rebate accruals covering sales from 2022 through 2025, after first IRA invoices came in above expectations. Non-GAAP figures reallocate this amount to the years the sales were earned. Source
  • DAYBUE quarterly sales rose 13%: DAYBUE net product sales were $110 million in the fourth quarter, up 13% from $97 million, mainly due to growth in unit sales. Source
  • RADIANT Phase 2 readout due August-October: Top-line results from the Phase 2 RADIANT study of remlifanserin in Alzheimer’s disease psychosis remain on track for August to October 2026, which management called an important upcoming potential catalyst. Source
  • Fourth quarter SG&A rose on marketing: Fourth quarter SG&A expense was $156 million, up from $130 million, mainly from higher marketing investment to support NUPLAZID and DAYBUE field expansion and marketing costs. Source
  • Non-cash tax benefit lifted net income: Fourth quarter net income included a non-cash income tax benefit of $250 million tied to the valuation allowance on deferred tax assets. The income tax line was a benefit of $247 million for the quarter. Source

“In the fourth quarter we received our first Inflation Reduction Act invoices for NUPLAZID inflation cap rebates”

Catherine Owen Adams, Chief Executive Officer

Guidance

AreaPeriodFigureAgainst last quarter
Total revenues Sourcefull year 2026$1.22 to $1.28 billion
NUPLAZID net product sales Sourcefull year 2026$760 to $790 million
DAYBUE net product sales Sourcefull year 2026$460 to $490 million
R&D expense Sourcefull year 2026$385 to $410 million
SG&A expense Sourcefull year 2026$660 to $700 million

What changed from last quarter

  • New: NUPLAZID customer-facing teams expanded by 30% in representatives, implemented in early 2026 and now fully deployed. Source
  • New: DAYBUE STIX oral solution shipped to first patient, with a broader launch planned for early second quarter 2026. Source

Fourth quarter and full year results

  • Revenue grew on GAAP and adjusted bases: GAAP total revenues were $284 million in the fourth quarter of 2025, up 9%, and $1.07 billion for the full year, up 12%. Non-GAAP adjusted total revenues were $298 million for the quarter, up 16%, and $1.08 billion for the year, up 14%. Source
  • Fourth quarter net income rose: Fourth quarter net income was $274 million, or $1.60 per diluted share, compared with $144 million, or $0.86 per diluted share, in the same quarter of 2024. Source
  • Full year net income and per-share: Full year 2025 net income was $391 million, or $2.30 per diluted share, compared with $226 million, or $1.36 per diluted share, in 2024. Source

NUPLAZID sales and IRA accounting

  • NUPLAZID adjusted quarterly sales rose 17%: Non-GAAP adjusted NUPLAZID net sales were $189 million in the fourth quarter, up 17% from $161 million. GAAP net sales for the quarter were $174 million. Source
  • Volume rose 9% for year, 13% in quarter: NUPLAZID volume grew 9% over the full year 2025 and 13% in the fourth quarter. The company stated the GAAP accounting adjustment does not reflect this underlying commercial performance. Source
  • IRA rebate estimate raised $20 million: The company recorded a $20 million change in estimate to NUPLAZID IRA rebate accruals covering sales from 2022 through 2025, after first IRA invoices came in above expectations. Non-GAAP figures reallocate this amount to the years the sales were earned. Source
  • Full year NUPLAZID adjusted sales $692 million: Full year 2025 non-GAAP adjusted NUPLAZID net product sales were $692 million, up 15% from $603 million, against GAAP net product sales of $680 million. Source

“We are seeing growing interest in our new DAYBUE STIX powder formulation as we prepare for a full launch in early Q2 of this year.”

Catherine Owen Adams, Chief Executive Officer

DAYBUE sales and STIX launch

  • DAYBUE quarterly sales rose 13%: DAYBUE net product sales were $110 million in the fourth quarter, up 13% from $97 million, mainly due to growth in unit sales. Source
  • DAYBUE full year sales up 12%: DAYBUE net product sales for full year 2025 were $391 million, up 12% from $348 million in 2024. Source
  • Community reach and named patient supply: Management attributed fourth quarter DAYBUE sales to expanding reach in the community and continued contribution from named patient supply programs outside the U.S. Source
  • DAYBUE STIX shipped to first patient: The oral solution has shipped to a first patient, with additional product supply in the channel. Management expects readiness for the broader launch in early second quarter 2026. Source

Pipeline and research spending

  • RADIANT Phase 2 readout due August-October: Top-line results from the Phase 2 RADIANT study of remlifanserin in Alzheimer’s disease psychosis remain on track for August to October 2026, which management called an important upcoming potential catalyst. Source
  • Fourth quarter R&D fell on prior payment: Fourth quarter R&D expense was $85 million, down from $101 million, because the same quarter of 2024 included a $28 million upfront payment for ACP-711 to Saniona. Source
  • Full year R&D spending increased: Full year 2025 research and development expenses were $329 million, compared with $303 million in 2024. Source

“anchored by remlifanserin, with the Phase 2 RADIANT study in Alzheimer’s disease psychosis serving as an important upcoming potential catalyst”

Catherine Owen Adams, Chief Executive Officer

Operating costs and sales expansion

  • Fourth quarter SG&A rose on marketing: Fourth quarter SG&A expense was $156 million, up from $130 million, mainly from higher marketing investment to support NUPLAZID and DAYBUE field expansion and marketing costs. Source
  • Full year SG&A increased to $549 million: Full year 2025 selling, general and administrative expenses were $549 million, compared with $488 million in 2024. Source
  • NUPLAZID sales team expanded 30%: The NUPLAZID customer-facing team added 30% more representatives, implemented in early 2026 and now fully deployed in the field. Source

Profitability and tax benefit

  • Non-cash tax benefit lifted net income: Fourth quarter net income included a non-cash income tax benefit of $250 million tied to the valuation allowance on deferred tax assets. The income tax line was a benefit of $247 million for the quarter. Source
  • Quarterly operating income fell from prior year: Fourth quarter income from operations was $17.4 million, against $153.5 million a year earlier. The 2024 quarter included a $146.5 million gain on sale of a non-financial asset. Source
  • Cost of product sales increased: Cost of product sales was $26.2 million in the fourth quarter, up from $21.8 million, and $89.0 million for the full year, up from $81.8 million. Source

Cash and balance sheet

  • Cash and investments rose to $820 million: Cash, cash equivalents and investment securities totaled $820 million at December 31, 2025, compared with $756 million a year earlier. Source
  • Stockholders’ equity rose to $1.23 billion: Total stockholders’ equity was $1,227,390 thousand at December 31, 2025, against $732,793 thousand a year earlier. Source
  • Receivables and inventory increased: Accounts receivable, net were $121.5 million, up from $98.7 million, and inventory was $34.7 million, up from $21.9 million. Source

Coming up, as management said on 25 February 2026

  • RADIANT Phase 2 top-line results: Top-line results from the Phase 2 study of remlifanserin in Alzheimer’s disease psychosis are expected between August and October 2026. Source
  • DAYBUE STIX broader launch: The company expects to be ready for the planned broader launch of DAYBUE STIX in early second quarter 2026. Source

Figures management reported

FigureReported
NUPLAZID GAAP net product sales, fourth quarter 2025 Source$174 million
NUPLAZID GAAP net product sales, full year 2025 Source$680 million
NUPLAZID volume growth, full year 2025 Source9%
DAYBUE GAAP net product sales, fourth quarter 2025 Source$110 million
DAYBUE GAAP net product sales, full year 2025 Source$391 million
R&D expense, full year 2025 Source$329 million
RADIANT Phase 2 top-line readout timing SourceAugust to October 2026
DAYBUE STIX launch milestone SourceShipped to first patient

Risks management discussed

  • Regulatory: First Inflation Reduction Act invoices for NUPLAZID rebates were higher than expected, leading to a $20 million change in estimate to rebate accruals. Source

Earlier plans management reported on

  • On track: Management states the Phase 2 readout for the remlifanserin Alzheimer’s disease psychosis study remains on track for the stated timeframe. Source
  • Not stated: Management expects to be ready for the planned broader DAYBUE STIX launch in early second quarter 2026; no status is given beyond that expectation. Source

Other quarters

Summarised with AI from the documents the company filed with the SEC. Every point is checked against the filing before it is shown: management’s own words word for word, figures against the line or table row they come from. A point that fails the check is left out. Source opens the filing at that line.